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  • 维生素D3

    Vitamin D3

    维生素D3
    产品编号 CFN90027
    CAS编号 67-97-0
    分子式 = 分子量 C27H44O = 384.64
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Miscellaneous
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    维生素D3 CFN90027 67-97-0 10mg QQ客服:2056216494
    维生素D3 CFN90027 67-97-0 20mg QQ客服:2056216494
    维生素D3 CFN90027 67-97-0 50mg QQ客服:2056216494
    维生素D3 CFN90027 67-97-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Semmelweis Unicersity (Hungary)
  • Helmholtz Zentrum München (Germany)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Illinois (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Universidade Federal de Santa Catarina (Brazil)
  • Monash University Sunway Campus (Malaysia)
  • Texas A&M University (USA)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Lodz University of Technology (Poland)
  • Auburn University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem. 2016, 408(15)
  • Front Plant Sci.2017, 8:723
  • University of Limpopo2016, 1777
  • Front. Pharmacol.2022, 901563.
  • J Ethnopharmacol.2021, 267:113615.
  • ACS Omega2020, 5,33,20825-20830
  • Integr Cancer Ther.2018, 17(3):832-843
  • Molecules2020, 25(4):892
  • Molecules. 2013, 18(7):7376-88
  • PLoS One.2018, 13(4):e0195642
  • Biomed Pharmacother.2019, 111:262-269
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Nutrients.2017, 10(1)
  • Front Pharmacol.2021, 12:635510.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Pol J Microbiol.2021, 70(1):117-130.
  • Research Square2021, 10.21203.
  • Postharvest Biol Tec2019, 149:18-26
  • Natural Product Communications2020, doi: 10.1177.
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Molecules.2020, 25(11):2599.
  • JEJU National University2022, 24032.
  • Phytomedicine.2022, 100:154085.
  • ...
  • 生物活性
    Description: Vitamin D3 is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. Supplemental calcium and Vitamin D3 may increase TGFβ1 expression and shift TGFα expression downward from the differentiation to the proliferation zone in the crypts in the normal-appearing colorectal mucosa of sporadic colorectal adenoma patients.
    Targets: TGF-β/Smad
    In vitro:
    J Pharm Biomed Anal. 2014 Mar;91:73-80.
    Development of a validated UPLC method for simultaneous estimation of both free and entrapped (in solid lipid nanoparticles) all-trans retinoic acid and cholecalciferol (vitamin D3) and its pharmacokinetic applicability in rats.[Pubmed: 24440824]
    A sensitive ultra-performance liquid chromatography (UPLC) method was developed for simultaneous estimation of all-trans retinoic acid (ATRA) and cholecalciferol (vitamin D3) in rat plasma.
    METHODS AND RESULTS:
    The method was validated over the linear range of 1.0-5000ng/ml (r(2)=0.999) for both vitamins with a limit of detection of 0.5ng/ml. Chromatographic separation was achieved using liquid-liquid extraction (LLE) on an Acquity BEH RP 18 column (2.1mm×50mm, I.D. 1.7μm), with mobile phase comprising of acetonitrile:methanol:water (90:8:2, v/v/v), at a flow rate of 0.20ml/min and a total run time of 5min. Intra and inter-day variability (RSD) was ≤3.1%, and the accuracy varied between 95.4-99.9% and 95.3-101.1% respectively, for ATRA and 98.5-100.8% and 99.3-101.7%, respectively for vitamin D3. High recovery of ≥96.0% for ATRA and ≥87.80% for vitamin D3 was achieved. ATRA and vitamin D3 were stable in plasma under different storage and processing conditions. The method was applied to estimate the total drug content and entrapment efficiency of ATRA and vitamin D3 loaded solid lipid nanoparticles (SLNs). Concentration of these two agents was determined in rat plasma after simultaneous subcutaneous administration in free form or when loaded into SLNs thus establishing pharmacokinetic application of the developed procedure.
    CONCLUSIONS:
    Results indicated an improvement in AUC0-∞ by 5.4 times and 29.4 times for ATRA and vitamin D3, respectively, upon their incorporation into SLNs. Simultaneous administration of these two vitamins and their improved and prolonged bioavailability has scope for their use in treatment and control of tuberculosis.
    In vivo:
    Eur J Endocrinol. 2015 Mar;172(3):235-41.
    Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3.[Pubmed: 25661743]
    The objective was to assess the amount of vitamin D3 stored in adipose tissue after long-term supplementation with high dose vitamin D3. A cross-sectional study on 29 subjects with impaired glucose tolerance who had participated in a randomized controlled trial with vitamin D3 20 000 IU (500 μg) per week vs placebo for 3-5 years.
    METHODS AND RESULTS:
    Abdominal subcutaneous fat tissue was obtained by needle biopsy for the measurements of vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3). Body fat was measured with dual-energy X-ray absorptiometry, and serum 25(OH)D3 level was quantified. In the subjects given vitamin D3, the median concentrations of serum 25(OH)D3, fat vitamin D3, and fat 25(OH)D3 were 99 nmol/l, 209 ng/g, and 3.8 ng/g, respectively; and correspondingly in the placebo group 62  nmol/l, 32 ng/g, and 2.5 ng/g. If assuming an equal amount of vitamin D3 stored in all adipose tissue in the body, the median body store was 6.6 mg vitamin D3 and 0.12 mg 25(OH)D3 in those given vitamin D3.
    CONCLUSIONS:
    Subcutaneous adipose tissue may store large amounts of vitamin D3. The clinical importance of this storage needs to be determined.
    J Steroid Biochem Mol Biol. 2015 Apr;148:275-82.
    Dissecting high from low responders in a vitamin D3 intervention study.[Pubmed: 25448738]
    Vitamin D3 is a pleiotropic signaling molecule that has via activation of the transcription factor vitamin D receptor (VDR) a direct effect on the expression of more than 100 genes. The aim of this study was to find transcriptomic and clinical biomarkers that are most suited to identify vitamin D3 responders within 71 pre-diabetic subjects during a 5-month intervention study (VitDmet).
    METHODS AND RESULTS:
    In hematopoietic cells, the genes ASAP2, CAMP, CD14, CD97, DUSP10, G0S2, IL8, LRRC8A, NINJ1, NRIP1, SLC37A2 and THBD are known as primary vitamin D targets. We demonstrate that each of these 12 genes carries a conserved VDR binding site within its genomic region and is expressed in human peripheral blood mononuclear cells (PBMCs). The changes in the expression of these genes in human PBMCs at the start and the end of the vitamin D-intervention were systematically correlated with the alteration in the circulating form of vitamin D3, 25-hydroxyvitamin D3 (25(OH)D3). Only 39-44 (55-62%) of the study subjects showed a highly significant response to vitamin D3, i.e., we considered them as "responders". In comparison, we found for 37-53 (52-75%) of the participants that only 12 biochemical and clinical parameters, such as concentrations of parathyroid hormone (PTH) and insulin, or computed values, such as homeostatic model assessment and insulin sensitivity index, show a correlation with serum 25(OH)D3 levels that is as high as that of the selected VDR target genes. All 24 parameters together described the pleiotropic vitamin D response of the VitDmet study subjects. Interestingly, they demonstrated a number of additional correlations that define a network, in which PTH plays the central role.
    CONCLUSIONS:
    In conclusion, vitamin D3-induced changes in human PBMCs can be described by transcriptomic and serum biomarkers and allow a segregation into high and low responders. This article is part of a Special Issue entitled '17th Vitamin D Workshop' .
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5998 mL 12.9992 mL 25.9983 mL 51.9967 mL 64.9958 mL
    5 mM 0.52 mL 2.5998 mL 5.1997 mL 10.3993 mL 12.9992 mL
    10 mM 0.26 mL 1.2999 mL 2.5998 mL 5.1997 mL 6.4996 mL
    50 mM 0.052 mL 0.26 mL 0.52 mL 1.0399 mL 1.2999 mL
    100 mM 0.026 mL 0.13 mL 0.26 mL 0.52 mL 0.65 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:2056216494
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:3257982914
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:2056216494
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:215959384
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:215959384
    7-酮基胆固醇; 7-Ketocholesterol CFN91812 566-28-9 C27H44O2 = 400.6 5mg QQ客服:2056216494
    7-氧胆固醇乙酯; 7-Oxocholesteryl acetate CFN91647 809-51-8 C29H46O3 = 442.7 5mg QQ客服:1457312923
    27-羟基胆固醇; 27-Hydroxycholesterol CFN90609 20380-11-4 C27H46O2 = 402.65 10mg QQ客服:2056216494
    胆甾-4,6-二烯-3-醇; Cholest-4,6-diene-3-ol CFN91582 14214-69-8 C27H44O = 384.6 5mg QQ客服:2056216494
    松甾酮A; Ponasterone A CFN99419 13408-56-5 C27H44O6 = 464.6 5mg QQ客服:1457312923

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