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  • 原莪术烯醇

    Procurcumenol

    原莪术烯醇
    产品编号 CFN92647
    CAS编号 21698-40-8
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma phaeocaulis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    原莪术烯醇 CFN92647 21698-40-8 1mg QQ客服:1457312923
    原莪术烯醇 CFN92647 21698-40-8 5mg QQ客服:1457312923
    原莪术烯醇 CFN92647 21698-40-8 10mg QQ客服:1457312923
    原莪术烯醇 CFN92647 21698-40-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of Gdansk (Poland)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Wageningen University (Netherlands)
  • University of Perugia (Italy)
  • Complutense University of Madrid (Spain)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University Medical Center Mainz (Germany)
  • University of Virginia (USA)
  • Weizmann Institute of Science (Israel)
  • Utah State University (USA)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Melbourne (Australia)
  • Wroclaw Medical University (Poland)
  • Chang Gung University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2017, 18(5)
  • Int J Mol Sci.2022, 23(10):5813.
  • Int J Mol Sci.2021, 22(12):6466.
  • Antioxidants (Basel).2020, 9(4):326.
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Legume Science2021, 3(4): e101.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • University of Stuttgart2021, 11682.
  • J Cancer.2019, 10(23):5843-5851
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • FEBS J.2022, 10.1111:febs.16676.
  • Int J Mol Med.2019, 43(6):2516-2522
  • Am J Chin Med.2016, 44(6):1255-1271
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Pharm Biol.2022, 60(1):2040-2048.
  • Nat Prod Communications2018, 10.1177
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Research on Crops.2017, 18(2)
  • Front Immunol. 2020, 11:62.
  • Life Sci.2018, 209:498-506
  • FASEB J.2019, 33(2):2026-2036
  • Primary and Industrial.2018, 52(11)
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • ...
  • 生物活性
    Description: Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release of tumor necrosis factor-a (TNF-a).
    Targets: TNF-α | NO
    In vitro:
    J Nat Prod. 2013 Feb 22;76(2):223-9.
    Sesquiterpenes from the rhizomes of Curcuma heyneana.[Pubmed: 23387824]

    METHODS AND RESULTS:
    Four new germacranes [heyneanones A-D (1-4)], three new guaianes [4,10-epizedoarondiol (5), 15-hydroxyProcurcumenol (6), 12-hydroxycurcumenol (7)], and two new spirolactones [curcumanolides C (8) and D (9)] were isolated from the rhizomes of Curcuma heyneana together with 13 known sesquiterpenes and two known labdane-type diterpenes.
    CONCLUSIONS:
    Among the isolated compounds, heyneanone A (1), heyneanone C (3), 4,10-epizedoarondiol (5), Procurcumenol (16), aerugidiol (17), zerumin A (23), and (E)-15,16-bisnorlabda-8(17),11-dien-13-one (24) inhibited protein tyrosine phosphatase 1B (PTP1B) with IC(50) values of 42.5, 35.2, 35.1, 45.6, 35.7, 10.4, and 14.7 μM, respectively.
    ScientificWorldJournal. 2014;2014:321943.
    Cytotoxic constituents from the rhizomes of Curcuma zedoaria.[Pubmed: 25126594]
    Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer.
    METHODS AND RESULTS:
    The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (Ca Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay. Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), Procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0(1,5)]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoProcurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19). Compounds (1-19) were evaluated for their antiproliferative effect using MTT assay against four cancer cell lines (Ca Ski, MCF-7, PC-3, and HT-29).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:215959384
    异莪术醇; Isocurcumenol CFN92618 24063-71-6 C15H22O2 = 234.3 20mg QQ客服:1457312923
    莪术醇; 姜黄醇; Curcumol CFN99187 4871-97-0 C15H24O2 = 236.35 20mg QQ客服:2056216494
    4beta,12-dihydroxyguaian-6,10-diene; 4beta,12-dihydroxyguaian-6,10-diene CFN90947 461644-90-6 C15H24O2 = 236.34 5mg QQ客服:1457312923
    Chrysothol; Chrysothol CFN97477 911714-91-5 C15H26O2 = 238.4 5mg QQ客服:1413575084
    泽泻醇; Alismol CFN97446 87827-55-2 C15H24O = 220.4 10mg QQ客服:2056216494
    环氧泽泻烯; Alismoxide CFN99775 87701-68-6 C15H26O2 = 238.37 20mg QQ客服:1413575084
    愈创醇; Guaiol CFN96326 489-86-1 C15H26O = 222.4 5mg QQ客服:215959384
    Teuclatriol; Teuclatriol CFN99634 152110-17-3 C15H28O3 = 256.4 5mg QQ客服:2159513211
    苍术苷A; Atractyloside A CFN98560 126054-77-1 C21H36O10 = 448.5 20mg QQ客服:1413575084

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