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  • 紫杉宁 M

    Taxinine M

    紫杉宁 M
    产品编号 CFN96634
    CAS编号 135730-55-1
    分子式 = 分子量 C35H42O14 = 686.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The seeds of Chinese yew Taxus chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫杉宁 M CFN96634 135730-55-1 1mg QQ客服:3257982914
    紫杉宁 M CFN96634 135730-55-1 5mg QQ客服:3257982914
    紫杉宁 M CFN96634 135730-55-1 10mg QQ客服:3257982914
    紫杉宁 M CFN96634 135730-55-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • J Food Biochem.2019, 43(9):e12970
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  • Front Cell Dev Biol.2021, 9:764263.
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  • J Anal Toxicol.2021, bkab015.
  • ...
  • 生物活性
    Description: Taxinine M is a natural product from Chinese yew Taxus chinensis.
    In vitro:
    J Pharm Biomed Anal. 2015 Mar 25;107:346-54.
    Simultaneous determination of seven taxoids in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Taxus yunnanensis extracts.[Pubmed: 25645339]

    METHODS AND RESULTS:
    A rapid, sensitive and reliable method has been developed and validated for the simultaneous determination of seven taxoids including 10-deacetylbaccatin III (10-DAB III), baccatin III, 5-epi-canadensene, Taxinine M, 10-deacetyltaxol (10-DAT), cephalomannine and paclitaxel in rat plasma using docetaxel as the internal standard (IS). The plasma samples were pretreated by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was achieved on a C18 column (50 mm × 2.1 mm, 1.8 μm, Waters, USA) with a gradient elution program consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. Detection was performed under the selected reaction monitoring (SRM) scan using an electrospray ionization (ESI) in the positive ion mode. The mass transitions were as follows: m/z 567.4→444.9 for 10-DAB III, m/z 609.0→549.3 for baccatin III, m/z 617.4→496.9 for 5-epi-canadensene, m/z 709.6→649.3 for Taxinine M, m/z 834.8→307.9 for 10-DAT, m/z 854.5→285.4 for cephalomannine, m/z 876.8→307.3 for paclitaxel and m/z 830.8→549.6 for IS, respectively. All calibration curves exhibited good linearity (r(2)>0.99) over a wide concentration range for all components. The intra-day and inter-day precisions at three different levels were both less than 14.3% in terms of relative standard deviation (RSD) and the accuracies ranged from -8.3% to 14.8% in terms of relative error (RE). The extraction recoveries of the seven compounds ranged from 62.5% to 100.5%.
    CONCLUSIONS:
    The developed method was successfully applied to the pharmacokinetic study of the seven taxoids in rat plasma after oral administration of the crude extract of the twigs and leaves of Taxus yunnanensis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4562 mL 7.2812 mL 14.5624 mL 29.1248 mL 36.406 mL
    5 mM 0.2912 mL 1.4562 mL 2.9125 mL 5.825 mL 7.2812 mL
    10 mM 0.1456 mL 0.7281 mL 1.4562 mL 2.9125 mL 3.6406 mL
    50 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.5825 mL 0.7281 mL
    100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.2912 mL 0.3641 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7beta-Acetoxytaxuspine C ; 7beta-Acetoxytaxuspine C CFN96914 256347-91-8 C37H44O11 = 664.74 5mg QQ客服:3257982914
    Taxezopidine G; Taxezopidine G CFN96639 205440-22-8 C35H44O9 = 608.72 5mg QQ客服:1413575084
    7-去乙酰氧紫杉宁J; 7-Deacetoxytaxinine J CFN89400 18457-45-9 C37H46O10 = 650.75 5mg QQ客服:215959384
    Taxezopidine H; Taxezopidine H CFN95562 205440-23-9 C35H44O9 = 608.7 5mg QQ客服:1413575084
    2-去乙酰氧紫杉宁J; 2-Deacetoxytaxinine J CFN96989 119347-14-7 C37H46O10 = 650.76 10mg QQ客服:2159513211
    2,7-二去乙酰氧紫杉宁J; 2,7-Dideacetoxytaxinine J CFN96979 115810-14-5 C35H44O8 = 592.72 5mg QQ客服:3257982914
    9-Deacetyltaxinine E ; 9-Deacetyltaxinine E CFN96923 284672-78-2 C35H44O9 = 608.72 5mg QQ客服:215959384
    紫杉宁; Taxinine CFN96636 3835-52-7 C35H42O9 = 606.71 5mg QQ客服:2159513211
    紫杉宁 J ; Taxinine J CFN96635 18457-46-0 C39H48O12 = 708.80 5mg QQ客服:2056216494
    紫杉宁 M; Taxinine M CFN96634 135730-55-1 C35H42O14 = 686.70 5mg QQ客服:1457312923

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