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  • 1-羟基浆果赤霉素I

    1-Hydroxybaccatin I

    1-羟基浆果赤霉素I
    产品编号 CFN98378
    CAS编号 30244-37-2
    分子式 = 分子量 C32H44O14 = 652.7
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Diterpenoids
    植物来源 The barks of Taxus chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-羟基浆果赤霉素I CFN98378 30244-37-2 1mg QQ客服:1457312923
    1-羟基浆果赤霉素I CFN98378 30244-37-2 5mg QQ客服:1457312923
    1-羟基浆果赤霉素I CFN98378 30244-37-2 10mg QQ客服:1457312923
    1-羟基浆果赤霉素I CFN98378 30244-37-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Cincinnati (USA)
  • Wageningen University (Netherlands)
  • Technical University of Denmark (Denmark)
  • Weizmann Institute of Science (Israel)
  • Julius Kühn-Institut (Germany)
  • University of Hull (United Kingdom)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • Front Pharmacol.2022, 13:919230.
  • Reprod Toxicol.2020, 96:1-10.
  • J Ethnopharmacol.2017, 206:327-336
  • In Vivo.2022, 36(3):1136-1143.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Biomed Chromatogr.2020, e5021.
  • Pol J Microbiol.2021, 70(1):117-130.
  • Life (Basel).2021, 11(7):616.
  • Univerzita Karlova2021, 20.500.11956.
  • Int J Mol Sci.2020, 21(7):2530.
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Toxicol Mech Methods.2021, 1-12.
  • Microchemical Journal2018, 137:168-173
  • JABS2020, 14:2(2020)
  • J AOAC Int.2023, 106(1):56-64.
  • Sci Rep. 2017, 12953(7)
  • Journal of Chromatography A2020, 460942
  • ...
  • 生物活性
    Description: 1beta-Hydroxybaccatin I possesses significant antinociceptive activity against p- benzoquinone-induced abdominal contractions.
    In vivo:
    J Nat Med. 2013 Jul;67(3):512-8.
    Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel.[Pubmed: 23007175]
    Paclitaxel, the major active component of the yew tree, is used as an important anti-cancer agent.
    METHODS AND RESULTS:
    To obtain the monoclonal antibody (MAb) against paclitaxel for paclitaxel determination using immunoassay, 7-xylosyltaxol was conjugated to the carrier protein bovine serum albumin (BSA) to construct the immunogen, and the ratio of hapten in XylTax-BSA conjugate was determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. After immunization of mice with this conjugate, hybridomas secreting MAbs against paclitaxel were obtained by fusing the splenocytes with the mouse myeloma cell line SP2/0. After hybridoma screening, the anti-paclitaxel MAb 3A3 was obtained, which showed a relatively high specificity to paclitaxel (cross-reactivities against other naturally occurred taxanes: 7-xylosyltaxol, 31.8%; cephalomannine, 6.17%; baccatin III, 10-deacetyl-baccatin III, 1-hydroxybaccatin I, 13-acetyl-9-dihydrobaccatin III and 1-acetoxyl-5-deacetyl-baccatin I, <0.11%). Using the MAb 3A3, we established an indirect competitive enzyme-linked immunosorbent assay (icELISA) for paclitaxel determination with a detection range of 0.098-312.5 μg ml(-1). Determination of paclitaxel contents in various yew tree samples with this icELISA resulted in recovery rates ranging from 92 to 94.8%, and intra- and inter-assay variations of 3.6 and 4.7%, respectively.
    CONCLUSIONS:
    This icELISA provides a valuable method of paclitaxel determination for various purposes.
    J Ethnopharmacol. 2003 Dec;89(2-3):265-70.
    Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.[Pubmed: 14611890]

    METHODS AND RESULTS:
    Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I(1-Hydroxybaccatin I)) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated.
    CONCLUSIONS:
    All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5321 mL 7.6605 mL 15.321 mL 30.6419 mL 38.3024 mL
    5 mM 0.3064 mL 1.5321 mL 3.0642 mL 6.1284 mL 7.6605 mL
    10 mM 0.1532 mL 0.766 mL 1.5321 mL 3.0642 mL 3.8302 mL
    50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
    100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    紫杉宁 J ; Taxinine J CFN96635 18457-46-0 C39H48O12 = 708.80 5mg QQ客服:215959384
    紫杉宁 M; Taxinine M CFN96634 135730-55-1 C35H42O14 = 686.70 5mg QQ客服:3257982914
    去肉桂酰基紫杉奇芬; Decinnamoyltaxagifine CFN89028 130394-69-3 C28H38O12 = 566.6 5mg QQ客服:3257982914
    Taxumairol R ; Taxumairol R CFN96631 244167-04-2 C37H44O15 = 728.74 5mg QQ客服:1413575084
    Tasumatrol L ; Tasumatrol L CFN96647 847835-17-0 C36H44O15 = 716.73 5mg QQ客服:3257982914
    紫杉奇芬; Taxagifine CFN96641 81489-69-2 C37H44O13 = 696.74 5mg QQ客服:3257982914
    Taxezopidine L; Taxezopidine L CFN96638 219749-76-5 C39H46O15 = 754.78 5mg QQ客服:3257982914
    东北红豆杉素; Taxacin CFN96642 117229-54-6 C44H48O15 = 816.85 5mg QQ客服:215959384
    1-羟基浆果赤霉素I; 1-Hydroxybaccatin I CFN98378 30244-37-2 C32H44O14 = 652.7 5mg QQ客服:1413575084
    Taxumairol B; Taxumairol B CFN96632 142203-64-3 C28H40O12 = 568.61 5mg QQ客服:2056216494

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