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  • 紫杉素B

    Taxinine B

    紫杉素B
    产品编号 CFN99855
    CAS编号 18457-44-8
    分子式 = 分子量 C37H44O11 = 664.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Taxus chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫杉素B CFN99855 18457-44-8 1mg QQ客服:1457312923
    紫杉素B CFN99855 18457-44-8 5mg QQ客服:1457312923
    紫杉素B CFN99855 18457-44-8 10mg QQ客服:1457312923
    紫杉素B CFN99855 18457-44-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Hertfordshire (United Kingdom)
  • Sanford Burnham Medical Research Institute (USA)
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  • University of Hull (United Kingdom)
  • Florida A&M University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • J Pharm Biomed Anal.2017, 140:274-280
  • Phytomedicine.2019, 57:95-104
  • J Sep Sci.2018, 41(9):1938-1946
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Nutr Res Pract.2020, 14(3):203-217.
  • Int J Mol Sci.2018, 19(9):E2681
  • South African J of Plant&Soil2018, 29-32
  • Int J Mol Sci.2021, 22(19):10405.
  • Molecules.2022, 27(7):2360.
  • J Nat Med.2017, 71(2):457-462
  • J Cancer.2019, 10(23):5843-5851
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Mol Immunol. 2016, 78:121-132
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Toxins (Basel).2022, 14(12):824.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • J Pharmaceut Biomed2020, 182:113110
  • ...
  • 生物活性
    Description: Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
    In vitro:
    Thromb Res. 2010 Jun;125(6):e281-4.
    A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]
    Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
    METHODS AND RESULTS:
    An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
    CONCLUSIONS:
    All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5042 mL 7.5211 mL 15.0421 mL 30.0842 mL 37.6053 mL
    5 mM 0.3008 mL 1.5042 mL 3.0084 mL 6.0168 mL 7.5211 mL
    10 mM 0.1504 mL 0.7521 mL 1.5042 mL 3.0084 mL 3.7605 mL
    50 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6017 mL 0.7521 mL
    100 mM 0.015 mL 0.0752 mL 0.1504 mL 0.3008 mL 0.3761 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    东北红豆杉素; Taxacin CFN96642 117229-54-6 C44H48O15 = 816.85 5mg QQ客服:1413575084
    1-羟基浆果赤霉素I; 1-Hydroxybaccatin I CFN98378 30244-37-2 C32H44O14 = 652.7 5mg QQ客服:1413575084
    Taxumairol B; Taxumairol B CFN96632 142203-64-3 C28H40O12 = 568.61 5mg QQ客服:3257982914
    云南红豆杉甲素; Yunnanxane CFN96412 139713-81-8 C31H46O9 = 562.6 5mg QQ客服:3257982914
    10-Deacetylyunnanxane; 10-Deacetylyunnanxane CFN89037 1333323-17-3 C29H44O8 = 520.66 5mg QQ客服:215959384
    2-去乙酰氧-5α-羟基紫杉宁J ; 2-Deacetoxydecinnamoyltaxinine J CFN96913 87193-98-4 C28H40O9 = 520.61 5mg QQ客服:1457312923
    Decinnamoyltaxinine J ; Decinnamoyltaxinine J CFN96905 84652-33-5 C30H42O11 = 578.65 5mg QQ客服:2056216494
    2-去乙酰氧基紫杉素B; 2-Deacetoxytaxinine B CFN99887 191547-12-3 C35H42O9 = 606.7 5mg QQ客服:2056216494
    紫杉素B; Taxinine B CFN99855 18457-44-8 C37H44O11 = 664.8 5mg QQ客服:2159513211
    7beta-Acetoxytaxuspine C ; 7beta-Acetoxytaxuspine C CFN96914 256347-91-8 C37H44O11 = 664.74 5mg QQ客服:1413575084

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