东北红豆杉素

Taxacin

	产品编号	CFN96642
	CAS编号	117229-54-6
	分子式 = 分子量	C₄₄H₄₈O₁₅ = 816.85
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The leaves and twigs of Taxus cuspidata.
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产品名称	产品编号	CAS编号	包装	QQ客服
东北红豆杉素	CFN96642	117229-54-6	1mg	QQ客服：2056216494
东北红豆杉素	CFN96642	117229-54-6	5mg	QQ客服：2056216494
东北红豆杉素	CFN96642	117229-54-6	10mg	QQ客服：2056216494
东北红豆杉素	CFN96642	117229-54-6	20mg	QQ客服：2056216494

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Description:

Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.

In vitro:

Thromb Res. 2010 Jun;125(6):e281-4.

A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941 ]

Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
METHODS AND RESULTS:
An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action. All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7.
CONCLUSIONS:
All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.

In vivo:

Planta Med. 2009 Jun;75(8):814-22.

Effect of seven tricyclic diterpenoids from needles of Taxus media var. Hicksii on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of cytosolic compounds to the cell membrane in human neutrophils.[Pubmed: 19288401 ]

Taxol has been widely used as an anticancer drug for ovarian, breast, lung and prostate cancer. Some kinds of Taxus plants are widely distributed in the Northeast Asia region.
METHODS AND RESULTS:
We have isolated seven tricyclic diterpenoids, taxinine, taxagifine, 5-O-cinnamoylTaxacin I triacetate, 5-decinnamoyltaxinine J, 5-cinnamoyl-9-acetyltaxicin I, Taxacin and taxol from the needles of Taxus media var. Hicksii, and investigated their effects on stimulus-induced superoxide generation and translocation of cytosolic compounds to the cell membrane in human neutrophils. Six tricyclic diterpenoids used in this experiment suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. Taxinine significantly suppressed the superoxide generation induced by phorbol 12-myristate 13-acetate (PMA).
CONCLUSIONS:
The compounds also suppressed fMLP- and AA-induced tyrosyl or PMA-induced serine/threonine phosphorylation, and translocation of cytosolic compounds, p47 (phox), p67 (phox) and Rac to the cell membrane in parallel with the suppression of the stimulus-induced superoxide generation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Taxezopidine H; Taxezopidine H	CFN95562	205440-23-9	C₃₅H₄₄O₉ = 608.7	5mg	QQ客服：2159513211
2-去乙酰氧紫杉宁J; 2-Deacetoxytaxinine J	CFN96989	119347-14-7	C₃₇H₄₆O₁₀ = 650.76	10mg	QQ客服：3257982914
2,7-二去乙酰氧紫杉宁J; 2,7-Dideacetoxytaxinine J	CFN96979	115810-14-5	C₃₅H₄₄O₈ = 592.72	5mg	QQ客服：1413575084
9-Deacetyltaxinine E ; 9-Deacetyltaxinine E	CFN96923	284672-78-2	C₃₅H₄₄O₉ = 608.72	5mg	QQ客服：2159513211
紫杉宁; Taxinine	CFN96636	3835-52-7	C₃₅H₄₂O₉ = 606.71	5mg	QQ客服：215959384
紫杉宁 J ; Taxinine J	CFN96635	18457-46-0	C₃₉H₄₈O₁₂ = 708.80	5mg	QQ客服：1457312923
紫杉宁 M; Taxinine M	CFN96634	135730-55-1	C₃₅H₄₂O₁₄ = 686.70	5mg	QQ客服：2159513211
去肉桂酰基紫杉奇芬; Decinnamoyltaxagifine	CFN89028	130394-69-3	C₂₈H₃₈O₁₂ = 566.6	5mg	QQ客服：1413575084
Taxumairol R ; Taxumairol R	CFN96631	244167-04-2	C₃₇H₄₄O₁₅ = 728.74	5mg	QQ客服：1413575084
Tasumatrol L ; Tasumatrol L	CFN96647	847835-17-0	C₃₆H₄₄O₁₅ = 716.73	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2242 mL	6.1211 mL	12.2421 mL	24.4843 mL	30.6054 mL
5 mM	0.2448 mL	1.2242 mL	2.4484 mL	4.8969 mL	6.1211 mL
10 mM	0.1224 mL	0.6121 mL	1.2242 mL	2.4484 mL	3.0605 mL
50 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.4897 mL	0.6121 mL
100 mM	0.0122 mL	0.0612 mL	0.1224 mL	0.2448 mL	0.3061 mL

东北红豆杉素

Taxacin

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