2-去乙酰氧基紫杉素B

2-Deacetoxytaxinine B

	产品编号	CFN99887
	CAS编号	191547-12-3
	分子式 = 分子量	C₃₅H₄₂O₉ = 606.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The barks of Taxus chinensis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2-去乙酰氧基紫杉素B	CFN99887	191547-12-3	1mg	QQ客服：1413575084
2-去乙酰氧基紫杉素B	CFN99887	191547-12-3	5mg	QQ客服：1413575084
2-去乙酰氧基紫杉素B	CFN99887	191547-12-3	10mg	QQ客服：1413575084
2-去乙酰氧基紫杉素B	CFN99887	191547-12-3	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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PMID: 30417089

Kyung Hee University (Korea)

Shanghai Institute of Organic Chemistry (China)

National Cancer Institute (USA)

Gyeongsang National University (Korea)

Universiti Sains Malaysia (Malaysia)

University Medical Center Mainz (Germany)

Guangzhou Institutes of Biomedicine and Health (China)

Medical University of South Carolina (USA)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

The Australian National University (Australia)

Periyar University (India)

University of Leipzig (Germany)

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Description:

2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.

In vitro:

Thromb Res. 2010 Jun;125(6):e281-4.

A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]

Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
METHODS AND RESULTS:
An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
CONCLUSIONS:
All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
10-Deacetylyunnanxane; 10-Deacetylyunnanxane	CFN89037	1333323-17-3	C₂₉H₄₄O₈ = 520.66	5mg	QQ客服：2056216494
2-去乙酰氧-5α-羟基紫杉宁J ; 2-Deacetoxydecinnamoyltaxinine J	CFN96913	87193-98-4	C₂₈H₄₀O₉ = 520.61	5mg	QQ客服：2056216494
Decinnamoyltaxinine J ; Decinnamoyltaxinine J	CFN96905	84652-33-5	C₃₀H₄₂O₁₁ = 578.65	5mg	QQ客服：2056216494
2-去乙酰氧基紫杉素B; 2-Deacetoxytaxinine B	CFN99887	191547-12-3	C₃₅H₄₂O₉ = 606.7	5mg	QQ客服：2159513211
紫杉素B; Taxinine B	CFN99855	18457-44-8	C₃₇H₄₄O₁₁ = 664.8	5mg	QQ客服：1457312923
7beta-Acetoxytaxuspine C ; 7beta-Acetoxytaxuspine C	CFN96914	256347-91-8	C₃₇H₄₄O₁₁ = 664.74	5mg	QQ客服：2159513211
Taxezopidine G; Taxezopidine G	CFN96639	205440-22-8	C₃₅H₄₄O₉ = 608.72	5mg	QQ客服：2159513211
7-去乙酰氧紫杉宁J; 7-Deacetoxytaxinine J	CFN89400	18457-45-9	C₃₇H₄₆O₁₀ = 650.75	5mg	QQ客服：1457312923
Taxezopidine H; Taxezopidine H	CFN95562	205440-23-9	C₃₅H₄₄O₉ = 608.7	5mg	QQ客服：1457312923
2-去乙酰氧紫杉宁J; 2-Deacetoxytaxinine J	CFN96989	119347-14-7	C₃₇H₄₆O₁₀ = 650.76	10mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6483 mL	8.2413 mL	16.4826 mL	32.9652 mL	41.2065 mL
5 mM	0.3297 mL	1.6483 mL	3.2965 mL	6.593 mL	8.2413 mL
10 mM	0.1648 mL	0.8241 mL	1.6483 mL	3.2965 mL	4.1207 mL
50 mM	0.033 mL	0.1648 mL	0.3297 mL	0.6593 mL	0.8241 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.3297 mL	0.4121 mL