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  • 2-去乙酰氧基紫杉素B

    2-Deacetoxytaxinine B

    2-去乙酰氧基紫杉素B
    产品编号 CFN99887
    CAS编号 191547-12-3
    分子式 = 分子量 C35H42O9 = 606.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Taxus chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2-去乙酰氧基紫杉素B CFN99887 191547-12-3 1mg QQ客服:2159513211
    2-去乙酰氧基紫杉素B CFN99887 191547-12-3 5mg QQ客服:2159513211
    2-去乙酰氧基紫杉素B CFN99887 191547-12-3 10mg QQ客服:2159513211
    2-去乙酰氧基紫杉素B CFN99887 191547-12-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Anna University (India)
  • Max-Planck-Insitut (Germany)
  • National Hellenic Research Foundation (Greece)
  • MTT Agrifood Research Finland (Finland)
  • University of Limpopo (South Africa)
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  • University Medical Center Mainz (Germany)
  • University of British Columbia (Canada)
  • University of South Australia (Australia)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
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  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Food Chem.2017, 228:301-314
  • Nutrients.2020, 12(12):3607.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Biomed Chromatogr.2016, 30(10):1573-81
  • J. Food Composition and Analysis2022, 114:104731
  • Pathogens.2018, 7(3):E62
  • Int J Mol Sci.2019, 20(21):E5488
  • Phytother Res.2019, 33(7):1784-1793
  • Food Chem.2021, 360:130063.
  • Front Immunol.2017, 8:1542
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Sci Rep.2019, 9(1):18080
  • Planta Med.2016, 82(13):1208-16
  • Medicina (Kaunas).2020, 56(12):685.
  • Sci Rep.2018, 8(1):12970
  • Oncol Lett.2020, 20(4):122.
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • Molecules.2019, 24(7):E1290
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Molecules.2019, 24(21):E3834
  • ...
  • 生物活性
    Description: 2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.
    In vitro:
    Thromb Res. 2010 Jun;125(6):e281-4.
    A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata.[Pubmed: 20170941]
    Platelets are highly reactive components of the circulatory system. The cytoskeleton of a platelet is an important structure for platelet aggregation as stimulated by several agonists. An anticancer agent, taxol, has been suggested to exert platelet anti-aggregating activity by stabilizing microtubules during the aggregation process.
    METHODS AND RESULTS:
    An activity-guided fractionation was performed with a methanol extract of the leaves and twigs of Taxus cuspidata to isolate taxanes with platelet anti-aggregating effects. Compounds 1 to 7 - taxinine (1), taxinine A (2), taxinine B (3), 2-deacetoxytaxinine B (4), taxacin (5), taxchinin B (6), and taxol (7) - were obtained as the antiplatelet components of this plant. These taxane compounds present the possibility of securing new antiplatelet compounds which differ from currently available antiplatelet agents in chemical structure and possibly in mechanisms of action.
    CONCLUSIONS:
    All compounds showed stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA) (IC(50): 14.4, 64.5, 35.5, 16.0, 21.9, 28.6 and 48.2 versus 63.0microM) or U46619 (IC(50): 34.8, 24.9, 36.2, 35.0, 46.9, 71.9 and 68.7 versus 340microM). Compounds 1, 3, 4 and 5, with a cinnamoyl group at the C(5) position, showed strong inhibitory effects against AA-induced aggregation compared to compound 2 (with an -OH group at C(5)) or compounds with an oxetane ring at C(4),(5), such as compounds 6 and 7. All of the seven compounds were 5-13-fold more strongly inhibitory than ASA against U46619-induced aggregation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6483 mL 8.2413 mL 16.4826 mL 32.9652 mL 41.2065 mL
    5 mM 0.3297 mL 1.6483 mL 3.2965 mL 6.593 mL 8.2413 mL
    10 mM 0.1648 mL 0.8241 mL 1.6483 mL 3.2965 mL 4.1207 mL
    50 mM 0.033 mL 0.1648 mL 0.3297 mL 0.6593 mL 0.8241 mL
    100 mM 0.0165 mL 0.0824 mL 0.1648 mL 0.3297 mL 0.4121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    云南红豆杉甲素; Yunnanxane CFN96412 139713-81-8 C31H46O9 = 562.6 5mg QQ客服:2056216494
    10-Deacetylyunnanxane; 10-Deacetylyunnanxane CFN89037 1333323-17-3 C29H44O8 = 520.66 5mg QQ客服:215959384
    2-去乙酰氧-5α-羟基紫杉宁J ; 2-Deacetoxydecinnamoyltaxinine J CFN96913 87193-98-4 C28H40O9 = 520.61 5mg QQ客服:3257982914
    Decinnamoyltaxinine J ; Decinnamoyltaxinine J CFN96905 84652-33-5 C30H42O11 = 578.65 5mg QQ客服:215959384
    2-去乙酰氧基紫杉素B; 2-Deacetoxytaxinine B CFN99887 191547-12-3 C35H42O9 = 606.7 5mg QQ客服:3257982914
    紫杉素B; Taxinine B CFN99855 18457-44-8 C37H44O11 = 664.8 5mg QQ客服:1413575084
    7beta-Acetoxytaxuspine C ; 7beta-Acetoxytaxuspine C CFN96914 256347-91-8 C37H44O11 = 664.74 5mg QQ客服:3257982914
    Taxezopidine G; Taxezopidine G CFN96639 205440-22-8 C35H44O9 = 608.72 5mg QQ客服:3257982914
    7-去乙酰氧紫杉宁J; 7-Deacetoxytaxinine J CFN89400 18457-45-9 C37H46O10 = 650.75 5mg QQ客服:1413575084
    2-去乙酰氧紫杉宁J; 2-Deacetoxytaxinine J CFN96989 119347-14-7 C37H46O10 = 650.76 5mg QQ客服:1457312923

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