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  • 毒毛旋花子甙元

    Strophanthidine

    毒毛旋花子甙元
    产品编号 CFN70435
    CAS编号 66-28-4
    分子式 = 分子量 C23H32O6 = 404.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Thevetia peruviana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毒毛旋花子甙元 CFN70435 66-28-4 1mg QQ客服:2159513211
    毒毛旋花子甙元 CFN70435 66-28-4 5mg QQ客服:2159513211
    毒毛旋花子甙元 CFN70435 66-28-4 10mg QQ客服:2159513211
    毒毛旋花子甙元 CFN70435 66-28-4 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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  • 生物活性
    Description: Strophanthidin can induce calcium overload in vivo.
    Targets: Calcium Channel
    In vitro:
    European Journal of Pharmacology, 1980, 62(1):0-15.
    The antiarrhythmic effect of potassium and rubidium in strophanthidin toxicity.[Reference: WebLink]
    The effect of potassium and rubidium on the electrical and mechanical activity of canine Purkinje fibers were studied in vitro in the presence and absence of strophanthidin.
    METHODS AND RESULTS:
    High (5.4mM) K or 2.7 Rb decreased the force of contraction. In the presence of these ions, strophanthidin(Strophanthidine) increased the force of contraction as usual but the onset of arrhythmias was delayed. During the toxic stage of strophanthidin, high K or Rb increased the force of contraction, abolished the arrhythias and improved markedly the action potential. In the presence of calcium overload induced by exposure to a K-poor or Na-free solution, K and Rb induced an increase in force of contraction. And in ventricular muscle these ions relaxed the contracture induced by strophanthidin.
    CONCLUSIONS:
    It is concluded that K and Rb (in addition to other mechanisms) exert an antiarrhythmic action by increasing potassium conductance and by reducing the calcium overload induced by strophanthidin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4722 mL 12.3609 mL 24.7219 mL 49.4438 mL 61.8047 mL
    5 mM 0.4944 mL 2.4722 mL 4.9444 mL 9.8888 mL 12.3609 mL
    10 mM 0.2472 mL 1.2361 mL 2.4722 mL 4.9444 mL 6.1805 mL
    50 mM 0.0494 mL 0.2472 mL 0.4944 mL 0.9889 mL 1.2361 mL
    100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.4944 mL 0.618 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    毛花苷C; Lanatoside C CFN96196 17575-22-3 C49H76O20 = 985.1 20mg QQ客服:2159513211
    杠柳次苷; Periplocymarin CFN93081 32476-67-8 C30H46O8 = 534.69 5mg QQ客服:1413575084
    杠柳毒苷; Periplocin CFN90513 13137-64-9 C36H56O13 = 696.82 20mg QQ客服:2056216494
    Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]; Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside] CFN90985 1253421-94-1 C36H56O13 = 696.83 10mg QQ客服:215959384
    洋地黄毒甙; Digitoxin CFN98535 71-63-6 C41H64O13 = 764.94 20mg QQ客服:1413575084
    地高辛; Digoxin CFN98536 20830-75-5 C41H64O14 = 780.94 20mg QQ客服:1413575084
    羟基洋地黄毒苷; Gitoxin CFN70364 4562-36-1 C41H64O14 = 781.0 5mg QQ客服:3257982914
    Stauntosaponin A; Stauntosaponin A CFN96658 1417887-91-2 C28H38O7 = 486.60 5mg QQ客服:215959384
    蔓茎毒毛旋花子苷; Sarmentocymarin CFN89202 98633-61-5 C30H46O8 = 534.69 5mg QQ客服:1413575084
    Cryptanoside A; Cryptanoside A CFN89193 98570-81-1 C30H42O10 = 562.65 5mg QQ客服:3257982914

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