七里香甙甲

Helveticoside

	产品编号	CFN70428
	CAS编号	630-64-8
	分子式 = 分子量	C₂₉H₄₂O₉ = 534.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The herbs of Thevetia peruviana
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
七里香甙甲	CFN70428	630-64-8	1mg	QQ客服：2056216494
七里香甙甲	CFN70428	630-64-8	5mg	QQ客服：2056216494
七里香甙甲	CFN70428	630-64-8	10mg	QQ客服：2056216494
七里香甙甲	CFN70428	630-64-8	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

China Medical University (Taiwan)

Massachusetts General Hospital (USA)

Sri Ramachandra University (India)

University of Cincinnati (USA)

Universidade Federal de Goias (UFG) (Brazil)

University of Illinois (USA)

University of Bordeaux (France)

Mahatma Gandhi University (India)

Korea Intitute of Science and Technology (KIST) (Korea)

Regional Crop Research Institute (Korea)

Sanford Burnham Prebys Medical Discovery Institute (USA)

University of Melbourne (Australia)

Amity University (India)

University of Otago (New Zealand)

More...

Description:

Helveticoside, disulfiram, and lanatoside C as potential molecular targets in chronic obstructive pulmonary disease( COPD).

In vitro:

Lung, 2014, 192(1):87-93.

Protein-Protein Interaction Network Analysis in Chronic Obstructive Pulmonary Disease.[Reference: WebLink]

The aim of this study was to investigate the gene expression profile of chronic obstructive pulmonary disease (COPD) patients and non-COPD patients.
METHODS AND RESULTS:
Microarray raw data (GSE29133) was downloaded from Gene Expression Omnibus, including three COPD samples and three normal controls. Gene expression profiling was performed using Affymetrix human genome u133 plus 2.0 GeneChip. Differentially expressed genes were identified by Student's t test and genes with p < 0.05 were considered significantly changed. Up- and downregulated genes were submitted to the molecular signatures database (MSigDB) to search for a possible association with other previously published gene expression signatures. Furthermore, we constructed a COPD protein-protein interaction (PPI) network and used the connectivity map (cMap) to query for potential drugs for COPD. A total of 680 upregulated genes and 530 downregulated genes in COPD were identified. The MSigDB investigation found that upregulated genes were highly similar to gene signatures that respond to interferon and downregulated genes were similar to erythroid progenitor cells from fetal livers of E13.5 embryos with KLF1 knocked out. A PPI network consisting of 814 gene/proteins and 2,613 interactions was identified by Search Tool for the Retrieval of Interacting Genes. The cMap predicted helveticoside, disulfiram, and lanatoside C as the top three possible drugs that could perhaps treat COPD.
CONCLUSIONS:
Comprehensive analysis of the gene expression profile for COPD versus control reveals helveticoside, disulfiram, and lanatoside C as potential molecular targets in COPD. This evidence provides a new breakthrough in the medical treatment of patients with COPD.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
黄夹甙B; Thevetin B	CFN96147	27127-79-3	C₄₂H₆₆O₁₈ = 859.0	5mg	QQ客服：2056216494
g-羊角拗质; g-Strophanthin	CFN70427	630-60-4	C₂₉H₄₄O₁₂ = 584.7	5mg	QQ客服：2056216494
毒毛旋花子甙元; Strophanthidine	CFN70435	66-28-4	C₂₃H₃₂O₆ = 404.5	5mg	QQ客服：1457312923
七里香甙甲; Helveticoside	CFN70428	630-64-8	C₂₉H₄₂O₉ = 534.7	5mg	QQ客服：1413575084
磁麻苷; Cymarin	CFN70386	508-77-0	C₃₀H₄₄O₉ = 548.7	5mg	QQ客服：3257982914
铃兰毒苷; Convallatoxin	CFN70385	508-75-8	C₂₉H₄₂O₁₀ = 550.7	5mg	QQ客服：2159513211
K-毒毛旋花子苷; k-Strophanthoside	CFN70338	33279-57-1	C₄₂H₆₄O₁₉ = 873.0	5mg	QQ客服：1457312923
去乙酰毛花苷; Deslanoside	CFN91787	17598-65-1	C₄₇H₇₄O₁₉ = 943.09	10mg	QQ客服：1457312923
毛花苷C; Lanatoside C	CFN96196	17575-22-3	C₄₉H₇₆O₂₀ = 985.1	20mg	QQ客服：2159513211
杠柳次苷; Periplocymarin	CFN93081	32476-67-8	C₃₀H₄₆O₈ = 534.69	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8702 mL	9.351 mL	18.7021 mL	37.4042 mL	46.7552 mL
5 mM	0.374 mL	1.8702 mL	3.7404 mL	7.4808 mL	9.351 mL
10 mM	0.187 mL	0.9351 mL	1.8702 mL	3.7404 mL	4.6755 mL
50 mM	0.0374 mL	0.187 mL	0.374 mL	0.7481 mL	0.9351 mL
100 mM	0.0187 mL	0.0935 mL	0.187 mL	0.374 mL	0.4676 mL