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  • 甜菊苷

    Stevioside

    甜菊苷
    产品编号 CFN99548
    CAS编号 57817-89-7
    分子式 = 分子量 C38H60O18 = 804.88
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Stevia rebaudiana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜菊苷 CFN99548 57817-89-7 10mg QQ客服:3257982914
    甜菊苷 CFN99548 57817-89-7 20mg QQ客服:3257982914
    甜菊苷 CFN99548 57817-89-7 50mg QQ客服:3257982914
    甜菊苷 CFN99548 57817-89-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Copenhagen University (Denmark)
  • Michigan State University (USA)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Nanjing University of Chinese Medicine (China)
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  • Calcutta University (India)
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  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • National Cancer Center Research Institute (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Research Square2022, rs.3.rs-1948239
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Molecules.2021, 26(4):816.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Food Research International2016, 106-113
  • Phytother Res.2022, 35844057.
  • Front Immunol.2018, 9:2091
  • Applied Biological Chemistry2022, 65(12)
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Appl. Sci.2021, 11(19),9343.
  • Universite de Bordeaux2017, 2017BORD0867
  • Int J Mol Sci.2020, 21(8):2790.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • J Sep Sci.2022, 45(18):3556-3566.
  • Br J Pharmacol.2016, 173(2):396-410
  • Acta horticulturae2017, 1158:257-268
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • World J Mens Health.2019, 10.5534
  • Journal of Ginseng Research2021, 15 June.
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Pharm Biol.2022, 60(1):2040-2048.
  • Archives of Biological sciences2022, 00:21-21
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • ...
  • 生物活性
    Description: Stevioside is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside enjoys a dual positive effect by acting as an antihyperglycemic and a blood pressure-lowering substance, it may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.Stevioside exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax.
    Targets: TLR | NF-kB | TNF-α | IL Receptor | IkB | p38MAPK | ERK | JNK | p65 | Caspase | PDE | IKK
    In vitro:
    Int Immunopharmacol. 2014 Sep;22(1):192-9.
    Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells.[Pubmed: 24975657]

    METHODS AND RESULTS:
    The object of this study was to investigate the anti-inflammatory and anti-apoptosis function of stevioside and the possible molecular mechanisms for such activity in Staphylococcus aureus (S. aureus)-infected mouse mammary epithelial cells (MMECs). The cells were treated with varying doses of stevioside before infection with S. aureus. The live/dead cells were detected by immunofluorescence microscopy. The pro-inflammatory cytokines were determined by ELISA. The mRNA of TLR2 and proteins related to NF-κB, MAPK and apoptosis were analyzed by q-PCR. The relative protein expression levels were determined by Western blot. The results indicated that stevioside inhibited the mRNA and protein expression of TNF-α, IL-6 and IL-1β dose-dependently in S. aureus-stimulated MMECs. Stevioside suppressed the S. aureus-induced expression of TLR2 and proteins of the NF-κB and MAPK pathways as well as apoptosis. The mRNA levels of IκBα, p38, ERK, JNK, p65, caspase-3 and Bax were not influenced by the stevioside treatment.
    CONCLUSIONS:
    Stevioside exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax.
    Saudi J Biol Sci . 2019 Nov;26(7):1596-1601.
    Stevioside mediated chemosensitization studies and cytotoxicity assay on breast cancer cell lines MDA-MB-231 and SKBR3[Pubmed: 31762632]
    Abstract Cancer is one of the most impacting life-threatening disease for the human populace. Hence, over the years we have seen a consistent interest to study and investigate new treatments to cure and prevent this disease. Medicinal plants have played a progressive part in treatment since many years. In this research study, we have explored the cytotoxicity effect of purified bioactive compound isolated from Stevia rebaudiana leaves and the key mechanism responsible for apoptosis in human breast cancer cells. The anticancer properties of Stevia rebaudiana leaves has been suggested in earlier literature. Hence, the aim of this study was to investigate the cytotoxicity of purified stevioside in human breast cancer cell lines MDA-MB-231 and SKBR3. Results showed that purified stevioside inhibited the growth of cancerous cell lines. The IC50 obtained after treatment with stevioside on cancer cells MDA-MB-231 and SKBR3 are 55 μM and 66 μM respectively. This shows purified stevioside is capable of inducing apoptosis indicating its promising anticancer activity. However, so far chemosensitization effects of stevioside on breast cancer have not been fully explained by other studies. Hence, additionally, this study also evaluates the chemosensitization potential of stevioside in combination with 5-FU. This research study shows the importance of Stevia rebaudiana as a good source of bioactive compounds with high anti-cancer property. Keywords: Apoptosis; Cancer; Cytotoxicity effects; MDA-MB-231; SKBR3; Stevia rebaudiana.
    In vivo:
    Braz Oral Res. 2014 Jan-Feb;28(1).
    Effects of lactose-containing stevioside sweeteners on dental biofilm acidogenicity.[Pubmed: 25098824]
    The aim of this study was to evaluate the effect of a commercial lactose-containing stevioside sweetener on biofilm acidogenicity in vivo.
    METHODS AND RESULTS:
    Nine volunteers refrained from brushing their teeth for 3 days in five phases. On the 4th day of each phase, the pH of the biofilm was measured by the "Strip method". Interproximal plaque pH was measured before and up to 60 minutes after a 10 mL mouthrinse for 1 minute with the test solutions: I - sweetener with 93% lactose and 7% stevioside; II - sweetener with 6.8% saccharin, 13.6% cyclamate, and 0.82% stevioside; III - 18% sucrose solution (positive control); IV - mineral water (negative control); and V- 93% lactose solution. The results revealed that the most pronounced pH fall was found with sucrose (positive control), followed by the 93% lactose solution, the sweetener with lactose + stevioside, the sweetener with saccharin + cyclamate + stevioside, and finally water (negative control). According to the area under the curve, the two sweeteners containing stevioside were significantly different, and the sweetener with lactose + stevioside was significantly different from water but not from sucrose. The critical pH for dentin demineralization (pH ≤ 6.5) was reached by all volunteers after rinsing with sucrose solution, lactose solution, and the stevioside + lactose sweetener.
    CONCLUSIONS:
    Analysis of the data suggests that lactose-containing stevioside sweeteners may be cariogenic, especially to dentin.
    Metabolism. 2003 Mar;52(3):372-8.
    Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat.[Pubmed: 12647278 ]
    Stevioside, a glycoside present in the leaves of the plant, Stevia rebaudiana Bertoni (SrB), has acute insulinotropic effects in vitro. Its potential antihyperglycemic and blood pressure-lowering effects were examined in a long-term study in the type 2 diabetic Goto-Kakizaki (GK) rat.
    METHODS AND RESULTS:
    Rats were fed 0.025 g x kg(-1) x d(-1) of stevioside (purity > 99.6%) for 6 weeks. An intra-arterial catheter was inserted into the rats after 5 weeks, and conscious rats were subjected to arterial glucose tolerance test (2.0 g x kg(-1)) during week 6. Stevioside had an antihyperglycemic effect (incremental area under the glucose response curve [IAUC]): 985 +/- 20 (stevioside) versus 1,575 +/- 21 (control) mmol/L x 180 minutes, (P <.05), it enhanced the first-phase insulin response (IAUC: 343 +/- 33 [stevioside] v 136 +/- 24 [control] microU/mL insulin x 30 minutes, P <.05) and concomitantly suppressed the glucagon levels (total AUC: 2,026 +/- 234 [stevioside] v 3,535 +/- 282 [control] pg/mL x 180 minutes, P <.05). In addition, stevioside caused a pronounced suppression of both the systolic (135 +/- 2 v 153 +/- 5 mm Hg; P <.001) and the diastolic blood pressure (74 +/- 1 v 83 +/- 1 mm Hg; P <.001). Bolus injections of stevioside (0.025 g x kg(-1)) did not induce hypoglycemia. Stevioside augmented the insulin content in the beta-cell line, INS-1. Stevioside may increase the insulin secretion, in part, by induction of genes involved in glycolysis. It may also improve the nutrient-sensing mechanisms, increase cytosolic long-chain fatty acyl-coenzyme A (CoA), and downregulate phosphodiesterase 1 (PDE1) estimated by the microarray gene chip technology.
    CONCLUSIONS:
    In conclusion, stevioside enjoys a dual positive effect by acting as an antihyperglycemic and a blood pressure-lowering substance; effects that may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2424 mL 6.2121 mL 12.4242 mL 24.8484 mL 31.0605 mL
    5 mM 0.2485 mL 1.2424 mL 2.4848 mL 4.9697 mL 6.2121 mL
    10 mM 0.1242 mL 0.6212 mL 1.2424 mL 2.4848 mL 3.1061 mL
    50 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.497 mL 0.6212 mL
    100 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.2485 mL 0.3106 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    莱苞迪甙C; 莱苞迪苷C; Rebaudioside C CFN90258 63550-99-2 C44H70O22 = 951.02 20mg QQ客服:2159513211
    13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester; Stevia impurity (13-[(2-O-6-deoxy-beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid beta-D-glucopyranosyl ester) CFN95229 1309929-72-3 C44H70O22 = 951.0 5mg QQ客服:2056216494
    莱苞迪甙D; 莱苞迪苷D; Rebaudioside D CFN90257 63279-13-0 C50H80O28 = 1129.15 20mg QQ客服:2159513211
    莱苞迪苷E; Rebaudioside E CFN91096 63279-14-1 C44H70O23 = 967.02 5mg QQ客服:2056216494
    莱苞迪苷N; Rebaudioside N CFN91167 1220616-46-5 C56H90O32 = 1275.9 5mg QQ客服:215959384
    莱苞迪苷M; Rebaudioside M CFN70259 1220616-44-3 C56H90O33 = 1291.3 5mg QQ客服:215959384
    (4alpha,11beta,15beta)-11,15-二羟基贝壳杉-16-烯-18-酸beta-D-吡喃葡萄糖酯; Paniculoside II CFN97019 60129-64-8 C26H40O9 = 496.6 5mg QQ客服:215959384
    6'-O-Acetylpaniculoside II; 6'-O-Acetylpaniculoside II CFN97585 N/A C28H42O10 = 538.6 5mg QQ客服:215959384
    对映-9-羟基-15-氧代-16-贝壳杉烯-19-酸 beta-D-吡喃葡萄糖酯; ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester CFN97291 81263-96-9 C26H38O9 = 494.6 5mg QQ客服:1413575084
    对映-6,9-二羟基-15-氧代-16-贝壳杉烯-19-酸beta-D-吡喃葡萄糖酯; ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester CFN97293 81263-98-1 C26H38O10 = 510.6 5mg QQ客服:1413575084

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