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  • 甜菊双糖苷

    Steviolbioside

    甜菊双糖苷
    产品编号 CFN96485
    CAS编号 41093-60-1
    分子式 = 分子量 C32H50O13 = 642.73
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Stevia rebaudia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜菊双糖苷 CFN96485 41093-60-1 10mg QQ客服:3257982914
    甜菊双糖苷 CFN96485 41093-60-1 20mg QQ客服:3257982914
    甜菊双糖苷 CFN96485 41093-60-1 50mg QQ客服:3257982914
    甜菊双糖苷 CFN96485 41093-60-1 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Malaysia (Malaysia)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Lodz (Poland)
  • University of Perugia (Italy)
  • University of Malaya (Malaysia)
  • Agricultural Research Organization (ARO) (Israel)
  • Regional Crop Research Institute (Korea)
  • Macau University of Science and Technology (China)
  • Subang Jaya Medical Centre (Malaysia)
  • Aarhus University (Denmark)
  • Medical University of Gdansk (Poland)
  • Semmelweis Unicersity (Hungary)
  • Kitasato University (Japan)
  • Kazusa DNA Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2019, 10:1226
  • Integr Cancer Ther.2018, 17(3):832-843
  • J Food Biochem.2019, 43(9):e12970
  • Mol Microbiol.2019, 112(1):317-332
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • The Korea Journal of Herbology2016, 29-35
  • Int J Mol Sci.2022, 23(21):13406.
  • Biomolecules.2022, 12(12):1754.
  • Medicina (Kaunas).2020, 56(12):685.
  • Environ Toxicol.2022, 37(3):514-526.
  • J Plant Biotechnol.2023, 50:070-075.
  • Biomed Sci Letters.2020, 26:319-326
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Phytomedicine.2022, 99:154025.
  • Antioxidants (Basel).2022, 11(8):1471.
  • Molecules.2021, 26(2):313.
  • Phytochem Anal.2013, 24(5):493-503
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Ind Crops Prod.2014, 62:173-178
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • BMC Microbiol.2019, 19(1):78
  • ...
  • 生物活性
    Description: Steviolbioside is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside could be a potential remedy for human breast cancer. Steviolbioside also exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
    Targets: Antifection
    In vitro:
    Chemistry of Natural Compounds, 2011, 46(6):902-5.
    Antituberculosis activity of glycosides from Stevia rebaudiana and hybrid compounds of steviolbioside and pyridinecarboxylic acid hydrazides[Reference: WebLink]
    Stevioside and steviolbioside, glycosides from Stevia rebaudiana Bertoni, in addition to hybrid compounds synthesized from steviolbioside and the antituberculosis drug isoniazid and its isomer nicotinic acid hydrazide exhibited moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro (MIC = 7.5, 3.75, 5, and 10 μg/mL, respectively).
    Food Chem. 2016 Apr 1;196:155-60.
    Production of a bioactive sweetener steviolbioside via specific hydrolyzing ester linkage of stevioside with a β-galactosidase.[Pubmed: 26593477]

    METHODS AND RESULTS:
    A β-galactosidase from Kluyveromyces lactis was found to specifically catalyze hydrolysis of the glycosyl ester linkage of stevioside to yield Steviolbioside, a rare sweetener that also exists in Stevia rebaudiana leaves. In a packed bed reactor, a reaction coupling separation was realized and a production yield of Steviolbioside reached 90% in 6 h. The hydrolysis product Steviolbioside presented higher cytoxicity on human normal cells (hepatocytes cell L02 and intestinal epithelial cell T84) than stevioside did. Comparing to the typical chemotherapy agent, 5-fluorouracil (5-FU), Steviolbioside presents much lower cytotoxicity on all assayed human normal cells; it presented notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3.
    CONCLUSIONS:
    The remarkable inhibition on MDA-MB-231 cells makes Steviolbioside a potential remedy for human breast cancer, when Steviolbioside is served as a natural sweetener.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5559 mL 7.7793 mL 15.5586 mL 31.1173 mL 38.8966 mL
    5 mM 0.3112 mL 1.5559 mL 3.1117 mL 6.2235 mL 7.7793 mL
    10 mM 0.1556 mL 0.7779 mL 1.5559 mL 3.1117 mL 3.8897 mL
    50 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.6223 mL 0.7779 mL
    100 mM 0.0156 mL 0.0778 mL 0.1556 mL 0.3112 mL 0.389 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    杜克甙A; Dulcoside A CFN92266 64432-06-0 C38H60O17 = 788.9 5mg QQ客服:3257982914
    甜菊苷D; Stevioside D CFN95230 1310055-59-4 C38H60O17 = 788.9 5mg QQ客服:2056216494
    莱苞迪甙 G;莱苞迪苷 G; Rebaudioside G CFN90984 127345-21-5 C38H60O18 = 804.87 10mg QQ客服:215959384
    甜菊苷; Stevioside CFN99548 57817-89-7 C38H60O18 = 804.88 20mg QQ客服:2159513211
    瑞鲍迪甙F; Rebaudioside F CFN95215 438045-89-7 C43H68O22 = 937.0 5mg QQ客服:1413575084
    甜菊双糖苷A; Rebaudioside A CFN99110 58543-16-1 C44H70O23 = 967.01 20mg QQ客服:1457312923
    莱苞迪甙C; 莱苞迪苷C; Rebaudioside C CFN90258 63550-99-2 C44H70O22 = 951.02 20mg QQ客服:2056216494
    13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester; Stevia impurity (13-[(2-O-6-deoxy-beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid beta-D-glucopyranosyl ester) CFN95229 1309929-72-3 C44H70O22 = 951.0 5mg QQ客服:215959384
    莱苞迪甙D; 莱苞迪苷D; Rebaudioside D CFN90257 63279-13-0 C50H80O28 = 1129.15 20mg QQ客服:215959384
    莱苞迪苷E; Rebaudioside E CFN91096 63279-14-1 C44H70O23 = 967.02 5mg QQ客服:3257982914

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