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  • 甜茶苷

    Rubusoside

    甜茶苷
    产品编号 CFN90167
    CAS编号 64849-39-4
    分子式 = 分子量 C32H50O13 = 642.73
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Rubus Suavissimus S.Lee.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜茶苷 CFN90167 64849-39-4 10mg QQ客服:3257982914
    甜茶苷 CFN90167 64849-39-4 20mg QQ客服:3257982914
    甜茶苷 CFN90167 64849-39-4 50mg QQ客服:3257982914
    甜茶苷 CFN90167 64849-39-4 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Chung Hsing University (Taiwan)
  • Chulalongkorn University (Thailand)
  • Osmania University (India)
  • University of Toulouse (France)
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  • Universidad Industrial de Santander (Colombia)
  • Universidad Miguel Hernández (Spain)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(3):695.
  • Plants (Basel).2020, 9(11):1555.
  • Int J Mol Sci.2018, 19(9):E2681
  • Sci Rep.2019, 9:12132
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • J Biol Chem.2021, 297(6):101362.
  • Biomed Pharmacother.2021, 144:112300.
  • Exp Mol Med.2020, 52(4):629-642.
  • J. of Agricultural Science2015, 1916-9760
  • Cytotechnology2022, s10616
  • Int J Mol Sci.2021, 22(19):10220.
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Nat Prod Sci.2018, 24(2):109-114
  • Tumour Biol.2015, 36(12):9385-93
  • Molecules.2015, 20(11):20014-30
  • Front Pharmacol.2021, 12:635510.
  • Int J Mol Sci.2021, 22(11):5503.
  • Molecules.2019, 24(24),4583
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Pharmaceuticals (Basel).2021, 14(6):588.
  • Acta Chromatographica2016, 29(3)
  • Front Pharmacol.2018, 9:756
  • Int J Pharm.2022, 618:121636.
  • ...
  • 生物活性
    Description: Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.Rubusoside can improve the survival rate of palmitic acid- induced INS- 1 cells and inhibit the occurrence of apoptosis.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Int J Pharm. 2012 Sep 15;434(1-2):453-9.
    Reformulation of etoposide with solubility-enhancing rubusoside.[Pubmed: 22698860]
    Etoposide (ETO), a widely used anti-cancer drug, is constrained by its low aqueous solubility and by side effects from both the drug and its solubilizing excipients. In this study, a recently discovered natural solubilizer Rubusoside (RUB) was used to achieve the solubilization of ETO.
    METHODS AND RESULTS:
    Dynamic light scattering and freeze-fracture transmission electron microscopy studies showed that ETO and Rubusoside formed ETO-Rubusoside nanoparticles (~6 nm in diameter). The powder of ETO-Rubusoside nanoparticles was completely reconstitutable in water and remained stable in this solution at 25 and 37°C for at least 24h. Under other physiologic conditions, ETO solution was clear and free of precipitation at 25°C, but underwent various structural transformations. In PBS and simulated intestinal fluid, Rubusoside-solubilized ETO underwent epimerization and equilibrated to cis-ETO. In simulated gastric fluid, Rubusoside-solubilized ETO degraded to 4'-demethylepipodophyllotoxin-beta-d-glucoside and 4'-demethylepipodophyllotoxin. Higher temperatures favored epimerization or degradation. Furthermore, a side-by-side comparison with DMSO-solubilized ETO confirmed that the RUB-solubilized ETO showed no significant differences in cytotoxicity in colon, breast and prostate cancer cell lines.
    CONCLUSIONS:
    Rubusoside effectively solubilized and stabilized etoposide, which sets the stage for further toxicology, bioavailability, and efficacy investigations.
    Chinese Journal of Ethnomedicine & Ethnopharmacy, 2015, 24(24):16-8.
    Protective Effects of Rubusoside on the Ultrastructure and Cyt C Translocation Expression of the Palmitic Acid- induced INS- 1 Cells.[Reference: WebLink]
    To investigate the protective mechanism of Rubusoside treating on the palmitic acid- induced INS- 1 cells.
    METHODS AND RESULTS:
    MTT assay was used to detect the cell viability rate of control group,palmitic acid group and different concentrations of Rubusoside group. Transmission electron microscope( TEM) was used to observe the ultrastructur of every group and the immune electron microscopy was used to detect cytochrome C translocationexpression. As evidenced by MTT assay,the cell viability significantly was enhanced by different concentrations Rubusoside pretreatment. TEM revealed degenerative changes in the ultramicroscopic structure of palmitic acid- induced INS- 1 cells whereas various concentrationpretreatment with Rubusoside could significantly attenuated the deterioration of the damage. Immune electron microscopy showed that different concentrations Rubusoside could prevent the cytochrome C releasing from mitochondria to cytoplasm with palmitic acid induced.
    CONCLUSIONS:
    Rubusoside can improve the survival rate of palmitic acid- induced INS- 1 cells and inhibit the occurrence of apoptosis. It is suggested that the mechanism may be associated with the inhibition of the oxidative stress induced by palmitic acid and prevent the cytochrome C releasing from mitochondrial to cytoplasm,which can activate caspase cascade and a downstream signaling to apopotosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5559 mL 7.7793 mL 15.5586 mL 31.1173 mL 38.8966 mL
    5 mM 0.3112 mL 1.5559 mL 3.1117 mL 6.2235 mL 7.7793 mL
    10 mM 0.1556 mL 0.7779 mL 1.5559 mL 3.1117 mL 3.8897 mL
    50 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.6223 mL 0.7779 mL
    100 mM 0.0156 mL 0.0778 mL 0.1556 mL 0.3112 mL 0.389 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甜菊苷; Stevioside CFN99548 57817-89-7 C38H60O18 = 804.88 20mg QQ客服:1413575084
    瑞鲍迪甙F; Rebaudioside F CFN95215 438045-89-7 C43H68O22 = 937.0 5mg QQ客服:1457312923
    甜菊双糖苷A; Rebaudioside A CFN99110 58543-16-1 C44H70O23 = 967.01 20mg QQ客服:215959384
    莱苞迪甙C; 莱苞迪苷C; Rebaudioside C CFN90258 63550-99-2 C44H70O22 = 951.02 20mg QQ客服:3257982914
    13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester; Stevia impurity (13-[(2-O-6-deoxy-beta-D-glucopyranosyl-3-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid beta-D-glucopyranosyl ester) CFN95229 1309929-72-3 C44H70O22 = 951.0 5mg QQ客服:215959384
    莱苞迪甙D; 莱苞迪苷D; Rebaudioside D CFN90257 63279-13-0 C50H80O28 = 1129.15 20mg QQ客服:215959384
    莱苞迪苷E; Rebaudioside E CFN91096 63279-14-1 C44H70O23 = 967.02 5mg QQ客服:3257982914
    莱苞迪苷N; Rebaudioside N CFN91167 1220616-46-5 C56H90O32 = 1275.9 5mg QQ客服:215959384
    莱苞迪苷M; Rebaudioside M CFN70259 1220616-44-3 C56H90O33 = 1291.3 5mg QQ客服:2056216494
    (4alpha,11beta,15beta)-11,15-二羟基贝壳杉-16-烯-18-酸beta-D-吡喃葡萄糖酯; Paniculoside II CFN97019 60129-64-8 C26H40O9 = 496.6 5mg QQ客服:2056216494

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