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  • 羧基苍术苷;羟基苍术苷三钾盐

    Carboxyatractyloside

    羧基苍术苷;羟基苍术苷三钾盐
    产品编号 CFN90756
    CAS编号 77228-71-8
    分子式 = 分子量 C31H43K3O18S2 = 885.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Atractylodes lancea (Thunb.) DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羧基苍术苷;羟基苍术苷三钾盐 CFN90756 77228-71-8 10mg QQ客服:1413575084
    羧基苍术苷;羟基苍术苷三钾盐 CFN90756 77228-71-8 20mg QQ客服:1413575084
    羧基苍术苷;羟基苍术苷三钾盐 CFN90756 77228-71-8 50mg QQ客服:1413575084
    羧基苍术苷;羟基苍术苷三钾盐 CFN90756 77228-71-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • ...
  • 生物活性
    Description: Carboxyatractyloside poisoning causes multiple organ dysfunction and can be fatal, the signs of a poor prognosis including coagulation abnormalities, hyponatraemia, marked hypoglycaemia, icterus and hepatic and renal failure, without antidote. Carboxyatractyloside can induce permeability transition, and that ageing induced mitochondrial DNA disruption and release of cytochrome c; it induces the inhibitory effect of tamoxifen on nonspecific membrane permeability.
    Targets: Calcium Channel | P450 (e.g. CYP17)
    In vitro:
    Life Sci. 2011 Apr 11;88(15-16):681-7.
    Protective action of tamoxifen on carboxyatractyloside-induced mitochondrial permeability transition.[Pubmed: 21324322]
    Mitochondrial permeability transition is established after massive Ca(2+) accumulation inside the matrix, in addition to an inducer. The closure of the pore can be accomplished by adenosine diphosphate and the immunosuppressant cyclosporin A. Recently, the estrogen antagonist, tamoxifen, has been introduced as an inhibitor of the opening of the permeability transition pore. However, the mechanism by which this drug inhibits pore opening is still under discussion. This work was performed with the purpose of establishing the membrane system involved in tamoxifen-induced pore closure. For this purpose, permeability transition was induced after the addition of carboxyatractyloside, which is a specific reagent that interacts with the adenine nucleotide translocase.
    METHODS AND RESULTS:
    Permeability transition was assessed by analyzing matrix Ca(2+) release, transmembrane electric gradient, and mitochondrial swelling in aged, as well as in freshly prepared mitochondria. Also, cytochrome c content was analyzed in membrane mitochondria as well as in the supernatant. In freshly prepared mitochondria, tamoxifen, at the concentration of 10 μM, totally inhibited nonspecific membrane permeability induced by 1 μM carboxyatractyloside. In addition, tamoxifen inhibited non-specific permeability in aged mitochondria and diminished membrane fluidity.
    CONCLUSIONS:
    Plausibly, the inhibitory effect of tamoxifen on nonspecific membrane permeability, as induced by carboxyatractyloside, should be ascribed to a diminution, of membrane fluidity by this drug.
    Radiat Res. 2009 Nov;172(5):575-83.
    Cyclosporin A inhibits UV-radiation-induced membrane damage but is unable to inhibit carboxyatractyloside-induced permeability transition.[Pubmed: 19883225]
    This work was undertaken to gain further information on the chemical characteristics of the membrane entity involved in the formation of the nonspecific pore.
    METHODS AND RESULTS:
    Mitochondria were subjected to oxidative stress by exposure to UV radiation. The results indicate that ultraviolet C radiation induces structural modifications in the adenine nucleotide translocase that lead to membrane permeability transition. Membrane leakage was assessed by measuring mitochondrial Ca2+ transport, the transmembrane electric gradient, and mitochondrial swelling. UV-irradiated mitochondria were unable to retain matrix Ca2+ or to maintain a high level of membrane potential when Ca2+ was added; furthermore, UV-irradiated mitochondria underwent large amplitude swelling. Release of cytochrome c and formation of malondialdehyde, owing to lipid peroxidation, were also seen. Structural modifications of the translocase were revealed by an increase in the binding of the fluorescent probe eosin-5-maleimide to thiol residues of the ADP/ATP carrier.
    CONCLUSIONS:
    These modifications, taken together with findings indicating that cyclosporin resulted unable to inhibit carboxyatractyloside-induced permeability transition, prompted us to conclude that the translocase could constitute the nonspecific pore or at least be an important modulator of it.
    In vivo:
    Ann Trop Paediatr. 2005 Jun;25(2):125-34.
    Carboxyatractyloside poisoning in humans.[Pubmed: 15949201]
    Cocklebur (Xanthium strumarium) is an herbaceous annual plant with worldwide distribution. The seeds contain the glycoside Carboxyatractyloside, which is highly toxic to animals. We describe nine cases of Carboxyatractyloside poisoning in humans which, to our knowledge, has not previously been reported. The clinical, laboratory and histopathological findings and our therapeutic approach are also discussed.
    METHODS AND RESULTS:
    The patients presented with acute onset abdominal pain, nausea and vomiting, drowsiness, palpitations, sweating and dyspnoea. Three of them developed convulsions followed by loss of consciousness and death. Laboratory findings showed raised liver enzymes, indicating severe hepatocellular damage. BUN and creatinine levels were raised, especially in the fatal cases who also displayed findings of consumption coagulopathy. CPK-MB values indicative of myocardial injury were also raised, especially in the fatal cases. Three of the patients died within 48 hours of ingesting Carboxyatractyloside. Post-mortem histopathology of the liver confirmed centrilobular hepatic necrosis and renal proximal tubular necrosis, secondary changes owing to increased permeability and microvascular haemorrhage in the cerebrum and cerebellum, and leucocytic infiltrates in the muscles and various organs including pancreas, lungs and myocardium.
    CONCLUSIONS:
    Carboxyatractyloside poisoning causes multiple organ dysfunction and can be fatal. Coagulation abnormalities, hyponatraemia, marked hypoglycaemia, icterus and hepatic and renal failure are signs of a poor prognosis. No antidote is available and supportive therapy is the mainstay of treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1298 mL 5.6491 mL 11.2982 mL 22.5963 mL 28.2454 mL
    5 mM 0.226 mL 1.1298 mL 2.2596 mL 4.5193 mL 5.6491 mL
    10 mM 0.113 mL 0.5649 mL 1.1298 mL 2.2596 mL 2.8245 mL
    50 mM 0.0226 mL 0.113 mL 0.226 mL 0.4519 mL 0.5649 mL
    100 mM 0.0113 mL 0.0565 mL 0.113 mL 0.226 mL 0.2825 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    莱苞迪苷M; Rebaudioside M CFN70259 1220616-44-3 C56H90O33 = 1291.3 5mg QQ客服:2056216494
    (4alpha,11beta,15beta)-11,15-二羟基贝壳杉-16-烯-18-酸beta-D-吡喃葡萄糖酯; Paniculoside II CFN97019 60129-64-8 C26H40O9 = 496.6 5mg QQ客服:2159513211
    6'-O-Acetylpaniculoside II; 6'-O-Acetylpaniculoside II CFN97585 N/A C28H42O10 = 538.6 5mg QQ客服:1413575084
    对映-9-羟基-15-氧代-16-贝壳杉烯-19-酸 beta-D-吡喃葡萄糖酯; ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester CFN97291 81263-96-9 C26H38O9 = 494.6 5mg QQ客服:3257982914
    对映-6,9-二羟基-15-氧代-16-贝壳杉烯-19-酸beta-D-吡喃葡萄糖酯; ent-6,9-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester CFN97293 81263-98-1 C26H38O10 = 510.6 5mg QQ客服:3257982914
    对映-6,11-二羟基-15-氧代-16-贝壳杉烯-19-酸beta-D-吡喃葡萄糖酯; ent-6,11-Dihydroxy-15-oxo-16-kauren-19-oic acid beta-D-glucopyranosyl ester CFN97292 81263-97-0 C26H38O10 = 510.6 5mg QQ客服:3257982914
    苍术苷二钾盐; Atractyloside potassium salt CFN98561 102130-43-8 C30H44K2O16S2 = 802.99 20mg QQ客服:1413575084
    羧基苍术苷;羟基苍术苷三钾盐; Carboxyatractyloside CFN90756 77228-71-8 C31H43K3O18S2 = 885.1 20mg QQ客服:2056216494
    甜菊糖苷; Steviolmonoside CFN91504 60129-60-4 C26H40O8 = 480.6 5mg QQ客服:1457312923
    甜菊双糖苷; Steviolbioside CFN96485 41093-60-1 C32H50O13 = 642.73 20mg QQ客服:1413575084

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