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  • 大豆脑苷I

    Soyacerebroside I

    大豆脑苷I
    产品编号 CFN99242
    CAS编号 114297-20-0
    分子式 = 分子量 C40H75NO9 = 714.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Cerebrosides
    植物来源 The fruits of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大豆脑苷I CFN99242 114297-20-0 1mg QQ客服:215959384
    大豆脑苷I CFN99242 114297-20-0 5mg QQ客服:215959384
    大豆脑苷I CFN99242 114297-20-0 10mg QQ客服:215959384
    大豆脑苷I CFN99242 114297-20-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Indian Institute of Science (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biorxiv.2020, doi: 10.1101.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Natural Product Communications2020, doi: 10.1177.
  • Ind Crops Prod.2015, 67:185-191
  • J Biochem Mol Toxicol.2017, 31(9)
  • J Funct Foods2019, 54:449-456
  • J Food Biochem.2020, 44(6):e13198.
  • Neurochem Int.2020, 133:104629
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Molecules.2019, 25(1):E103
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Appl Biol Chem2019, 62:46
  • Applied Biological Chemistry2021, 64(4)
  • J Mol Recognit.2020, 33(2):e2819
  • J Med Food.2020, 23(6):633-640.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Pharmaceutics.2022, 14(3):564.
  • Antioxidants2022, 11(2),234.
  • Food Chem.2019, 279:80-87
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Pharmaceutics.2020, 12(9):845.
  • Phytother Res.2015, 29(7):1088-96
  • ...
  • 生物活性
    Description: Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity. Soyacerebroside I shows anti-inflammatory activity, it can inhibit the accumulation of pro-inflammatory iNOS protein and reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious inhibitory activity on IL-18 secretion in human peripheral blood mononuclear cells (PBMC).
    Targets: IL Receptor | COX | NOS
    In vitro:
    Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1235-7.
    A new phenanthrene glycoside and other constituents from Dioscorea opposita.[Pubmed: 15467243]

    METHODS AND RESULTS:
    Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, Soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR.
    CONCLUSIONS:
    Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.
    Arch Pharm Res. 2008 May;31(5):579-86.
    Cytotoxic constituents of Amanita subjunquillea.[Pubmed: 18481012]
    As part of our systematic study of Korean toxic mushrooms, we have investigated the constituents of Amanita subjunquillea.
    METHODS AND RESULTS:
    The column chromatographic separation of the MeOH extract of A. subjunquillea led to the isolation of four ergosterols, two cerebrosides and four cyclopeptides. Their structures were determined by spectroscopic methods to be (22E,24R)-5alpha,8alpha-epidioxyergosta-6,9,22-triene-3beta-ol (1), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (2), (22E,24R)-5alpha,6alpha-epoxyergosta-8,22-diene-3beta,7beta-diol (3), (24S)-ergost-7-en-3beta-ol (4), 8,9-dihydroSoyacerebroside I (5), Soyacerebroside I (6), beta-amanitin (7), phalloin (8), alpha-amanitin (9), and phalloidin (10). The compounds 1-6 and 8 were isolated for the first time from this mushroom. The isolated compounds were evaluated for the cytotoxicity against A549, SK-OV-3, SK-MEL-2 and HCT15 cells.
    CONCLUSIONS:
    Compound 9 exhibited significant cytotoxic activity against A549, SK-OV-3, SK-MEL-2 and HCT15 with ED(50) values of 1.47, 0.26, 1.57 and 1.32 microM, respectively.
    J Agric Food Chem. 2016 Feb 24;64(7):1540-8.
    Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.[Pubmed: 26853111]
    Cordyceps militaris (bei-chong-chaw, northern worm grass) is a precious and edible entomopathogenic fungus, which is widely used in traditional Chinese medicine (TCM) as a general booster for the nervous system, metabolism, and immunity. Saccharides, nucleosides, mannitol, and sterols were isolated from this fungus. The biological activity of C. militaris was attributed to the saccharide and nucleoside contents.
    METHODS AND RESULTS:
    In this study, the aqueous methanolic fraction of C. militaris fruiting bodies exhibited a significant anti-inflammatory activity. Bioactivity-guided fractionation of the active fraction led to the isolation of eight compounds, including one new and two known cerebrosides (ceramide derivatives), two nucleosides, and three sterols.
    CONCLUSIONS:
    Cordycerebroside A (1), the new cerebroside, along with Soyacerebroside I (2) and glucocerebroside (3) inhibited the accumulation of pro-inflammatory iNOS protein and reduced the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages. This is the first study on the isolation of cerebrosides with anti-inflammatory activity from this TCM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4006 mL 7.0028 mL 14.0056 mL 28.0112 mL 35.014 mL
    5 mM 0.2801 mL 1.4006 mL 2.8011 mL 5.6022 mL 7.0028 mL
    10 mM 0.1401 mL 0.7003 mL 1.4006 mL 2.8011 mL 3.5014 mL
    50 mM 0.028 mL 0.1401 mL 0.2801 mL 0.5602 mL 0.7003 mL
    100 mM 0.014 mL 0.07 mL 0.1401 mL 0.2801 mL 0.3501 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七草酰胺II; Gynuramide II CFN98367 295803-03-1 C42H83NO5 = 682.1 5mg QQ客服:215959384
    (2R)-2-(乙酰氧基)-N-[(1S,2S,3R)-2,3-双(乙酰氧基)-1-[(乙酰氧基)甲基]十七烷基]二十四碳酰胺; 2-2'-(Hydroxytetracosanoylamino)-octadecane-1,3,4-triol tetraacetate CFN98439 340702-68-3 C50H93NO9 = 852.3 5mg QQ客服:2159513211
    (2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇; 2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol CFN99649 154801-30-6 C42H85NO5 = 684.1 5mg QQ客服:2159513211
    大豆脑苷I; Soyacerebroside I CFN99242 114297-20-0 C40H75NO9 = 714.0 5mg QQ客服:2159513211
    大豆脑苷II; Soyacerebroside II CFN99250 115074-93-6 C40H75NO9 = 714.0 5mg QQ客服:1413575084
    Momor-脑苷脂I; Momor-cerebroside I CFN97031 606125-07-9 C48H93NO10 = 844.3 5mg QQ客服:3257982914
    脑苷脂B; Cerebroside B CFN97455 88642-46-0 C41H77NO9 = 728.1 5mg QQ客服:2159513211

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