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  • 脑苷脂B

    Cerebroside B

    脑苷脂B
    产品编号 CFN97455
    CAS编号 88642-46-0
    分子式 = 分子量 C41H77NO9 = 728.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Cerebrosides
    植物来源 From Boletus calopus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    脑苷脂B CFN97455 88642-46-0 1mg QQ客服:2159513211
    脑苷脂B CFN97455 88642-46-0 5mg QQ客服:2159513211
    脑苷脂B CFN97455 88642-46-0 10mg QQ客服:2159513211
    脑苷脂B CFN97455 88642-46-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Otago (New Zealand)
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  • Michigan State University (USA)
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  • University of Hawaii Cancer Center (USA)
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  • University of Illinois (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front. Physiol.2022, 790345.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Front Cell Dev Biol.2021, 9:588093.
  • Food Funct.2020, 11(2):1322-1333.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Int J Mol Sci.2022, 23(13):7115.
  • J Biosci.2020, 45:46.
  • J Sep Sci.2020, 201901140
  • Journal of Ginseng Research2021, 3 June.
  • Sci Rep.2017, 7:467-479
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Phytomedicine2022, 104:154337.
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Biochem Pharmacol. 2020, 177:114014.
  • Life (Basel).2021, 11(7):616.
  • Int J Mol Sci.2018, 19(2)
  • Molecules.2019, 24(12):E2286
  • Appl. Sci.2022, 12(4), 2032.
  • Processes2021, 9(1), 153.
  • Appl. Sci.2020, 10,1304
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • Plos One.2019, 15(2):e0220084
  • ...
  • 生物活性
    Description: Cerebroside B1b has antiulcerogenic activity.
    Targets: Antifection
    In vitro:
    Sci Rep. 2015 May 21;5:10486.
    Δ10(E)-Sphingolipid Desaturase Involved in Fusaruside Mycosynthesis and Stress Adaptation in Fusarium graminearum.[Pubmed: 25994332]
    Sphingolipids are biologically important and structurally distinct cell membrane components. Fusaruside (1) is a 10,11-unsaturated immunosuppressive fungal sphingolipid with medical potentials for treating liver injury and colitis, but its poor natural abundance bottlenecks its druggability.
    METHODS AND RESULTS:
    Here, fusaruside is clarified biosynthetically, and its efficacy-related 10,11-double bond can be generated under the regioselective catalysis of an unprecedented Δ10(E)-sphingolipid desaturase (Δ10(E)-SD). Δ10(E)-SD shares 17.7% amino acid sequence similarity with a C9-unmethylated Δ10-sphingolipid desaturase derived from a marine diatom, and 55.7% with Δ8(E)-SD from Fusarium graminearum. Heterologous expression of Δ10(E)-SD in Pichia pastoris has been established to facilitate a reliable generation of 1 through the Δ10(E)-SD catalyzed desaturation of cerebroside B (2), an abundant fungal sphingolipid. Site directed mutageneses show that the conserved histidines of Δ10(E)-SD are essential for the 10,11-desaturation catalysis, which is also preconditioned by the C9-methylation of the substrate. Moreover, Δ10(E)-SD confers improved survival and faster growth to fungal strains at low temperature and high salinity, in parallel with to higher contents of 1 in the mycelia.
    CONCLUSIONS:
    Collectively, the investigation describes a new Δ10(E)-sphingolipid desaturase with its heterologous expression fundamentalizing a biotechnological supply of 1, and eases the follow-up clarification of the immunosuppression and stress-tolerance mechanism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3734 mL 6.8672 mL 13.7344 mL 27.4688 mL 34.3359 mL
    5 mM 0.2747 mL 1.3734 mL 2.7469 mL 5.4938 mL 6.8672 mL
    10 mM 0.1373 mL 0.6867 mL 1.3734 mL 2.7469 mL 3.4336 mL
    50 mM 0.0275 mL 0.1373 mL 0.2747 mL 0.5494 mL 0.6867 mL
    100 mM 0.0137 mL 0.0687 mL 0.1373 mL 0.2747 mL 0.3434 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七草酰胺II; Gynuramide II CFN98367 295803-03-1 C42H83NO5 = 682.1 5mg QQ客服:1413575084
    (2R)-2-(乙酰氧基)-N-[(1S,2S,3R)-2,3-双(乙酰氧基)-1-[(乙酰氧基)甲基]十七烷基]二十四碳酰胺; 2-2'-(Hydroxytetracosanoylamino)-octadecane-1,3,4-triol tetraacetate CFN98439 340702-68-3 C50H93NO9 = 852.3 5mg QQ客服:215959384
    (2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇; 2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol CFN99649 154801-30-6 C42H85NO5 = 684.1 5mg QQ客服:215959384
    大豆脑苷I; Soyacerebroside I CFN99242 114297-20-0 C40H75NO9 = 714.0 5mg QQ客服:1148253675
    大豆脑苷II; Soyacerebroside II CFN99250 115074-93-6 C40H75NO9 = 714.0 5mg QQ客服:1148253675
    Momor-脑苷脂I; Momor-cerebroside I CFN97031 606125-07-9 C48H93NO10 = 844.3 5mg QQ客服:3257982914
    脑苷脂B; Cerebroside B CFN97455 88642-46-0 C41H77NO9 = 728.1 5mg QQ客服:1413575084

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