莽草酸

Shikimic acid

	产品编号	CFN99436
	CAS编号	138-59-0
	分子式 = 分子量	C₇H₁₀O₅ = 174.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The fruits of Illicium verum.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
莽草酸	CFN99436	138-59-0	10mg	QQ客服：2159513211
莽草酸	CFN99436	138-59-0	20mg	QQ客服：2159513211
莽草酸	CFN99436	138-59-0	50mg	QQ客服：2159513211
莽草酸	CFN99436	138-59-0	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Illinois (USA)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Universidad de La Salle (Mexico)

University of Leipzig (Germany)

Sri Ramachandra University (India)

Amity University (India)

University of Otago (New Zealand)

Medizinische Universit?t Wien (Austria)

Universidad Veracuzana (Mexico)

Worcester Polytechnic Institute (USA)

Institute of Pathophysiology Medical University of Vienna (Austria)

S.N.D.T. Women's University (India)

Ateneo de Manila University (Philippines)

University of Vienna (Austria)

More...

Description:

Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms, has great potential for the design and synthesis of enzyme inhibitors. It reversed the H2O2 induced oxidative damage in hepatocytes, probably through the inhibition of NF-κB, with the activation of PI3K/Akt/Nrf2 pathway and reduction of apoptosis by interfering the SAPK/JNK/Bax pathway; it also profoundly inhibited pancreatic lipase activity by 66%, thus providing another valuable therapeutic aspect for treating diet induced obesity in humans.

Targets:

ROS | NF-kB | JNK | Bcl-2/Bax | Nrf2 | SAPK | Akt

In vitro:

Antonie Van Leeuwenhoek. 2015 Feb;107(2):419-31.

Shikimic acid, a base compound for the formulation of swine/avian flu drug: statistical optimization, fed-batch and scale up studies along with its application as an antibacterial agent.[Pubmed: 25563634]

The sudden outbreak of swine flu has increased the global demand of shikimic acid which is an industrially interesting compound, as it is used as a key starting material for the synthesis of a neuraminidase inhibitor Tamiflu(®), for the treatment of antiviral infections such as swine flu.
METHODS AND RESULTS:
Statistical optimization and evaluation of medium components for the production of shikimic acid by Citrobacter freundii is addressed in the present investigation. Plackett-Burman design was applied for the screening of the most significant variables affecting shikimic acid production, where glucose, asparagine, KH2PO4, CaCO3 and agitation rate were the most significant factors. Response surface methodology was also employed to study the interaction among the most significant variables through which shikimic acid production increased to 12.76 g/L. Further, fed-batch studies resulted in the production of 22.32 g/L of shikimic acid. The scalability of the process was also confirmed by running 14 L bioreactor (7.5 L production medium) where 20.12 g/L of shikimic acid was produced.
CONCLUSIONS:
In addition the antibacterial activity of the shikimic acid produced was analysed against four Gram positive and four Gram negative bacteria and it was found to have a greater inhibition effect against the Gram negative bacteria.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
去氧野艽霉素盐酸盐; Deoxynojirimycin hydrochloride	CFN90484	73285-50-4	C₆H₁₄ClNO₄ = 199.6	5mg	QQ客服：2056216494
环己五醇, L-栎醇; vibo-Quercitol	CFN98778	488-76-6	C₆H₁₂O₅ = 164.2	20mg	QQ客服：3257982914
肌醇; Inositol	CFN91718	87-89-8	C₆H₁₂O₆ = 180.16	20mg	QQ客服：2056216494
(E)-1-甲氧基-2-O-(p-香豆酰)-myo-肌醇; (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol	CFN95609	1391715-18-6	C₁₆H₂₀O₈ = 340.3	20mg	QQ客服：2159513211
D-松醇; D-Pinitol	CFN99044	10284-63-6	C₇H₁₄O₆ = 194.2	20mg	QQ客服：3257982914
(-)-白雀木醇; L-Quebrachitol	CFN90586	642-38-6	C₇H₁₄O₆ = 194.18	5mg	QQ客服：1413575084
牛弥菜醇A; Conduritol A	CFN98868	526-87-4	C₆H₁₀O₄ = 146.1	10mg	QQ客服：3257982914
D-(-)-奎宁酸; D-(-)-Quinic acid	CFN99930	77-95-2	C₇H₁₂O₆ = 192.17	20mg	QQ客服：2056216494
莽草酸; Shikimic acid	CFN99436	138-59-0	C₇H₁₀O₅ = 174.2	20mg	QQ客服：1413575084
3,4-O-异亚丙基莽草酸; 3,4-O-Isopropylidene shikimic acid	CFN99852	183075-03-8	C₁₀H₁₄O₅ = 214.2	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.7405 mL	28.7026 mL	57.4053 mL	114.8106 mL	143.5132 mL
5 mM	1.1481 mL	5.7405 mL	11.4811 mL	22.9621 mL	28.7026 mL
10 mM	0.5741 mL	2.8703 mL	5.7405 mL	11.4811 mL	14.3513 mL
50 mM	0.1148 mL	0.5741 mL	1.1481 mL	2.2962 mL	2.8703 mL
100 mM	0.0574 mL	0.287 mL	0.5741 mL	1.1481 mL	1.4351 mL