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  • 牛弥菜醇A

    • 牛弥菜醇A

    Conduritol A

    牛弥菜醇A
    		产品编号 CFN98868
    CAS编号 526-87-4
    分子式 = 分子量 C6H10O4 = 146.1
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The barks of Marsdenia condurango
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牛弥菜醇A CFN98868 526-87-4 1mg QQ客服：2159513211
    牛弥菜醇A CFN98868 526-87-4 5mg QQ客服：2159513211
    牛弥菜醇A CFN98868 526-87-4 10mg QQ客服：2159513211
    牛弥菜醇A CFN98868 526-87-4 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Toxicol In Vitro.2022, 81:105346.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Molecules2022, 27(14):4601
  • GxABT2022, 2268.2:15515.
  • Appl. Sci. 2021, 11(8),3437.
  • Molecules.2021, 26(2):E255.
  • Molecules.2024, 29(5):1171.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.
  • Front Pharmacol.2020, 11:683.
  • Food Res Int.2020, 133:109130.
  • Processes2020, 8(12),1540.
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Sci Rep.2019, 9(1):4646
  • Molecules.2023, 28(8):3490.
  • Plant Cell Physiol.2023, 64(7):716-728.
  • Front Pharmacol.2022, 13:883475.
  • Separations2023, 10(4),255.
  • Antioxidants2022, 11(2),234.
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  • Food Chem.2019, 276:768-775
  • Nutrients.2021, 13(8):2901.
  • Phytochemistry Letters2015, 243-247
  • ...
    • 生物活性
    Description: Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase.
    Targets: TNF-α | Lens aldose reductase
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.
    Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862]
    To investigates the mechanism of hypooglycemic effect of conduritol A of stems of Gymnema sylvestre.
    METHODS AND RESULTS:
    Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. Compared with diabetic model mice, high and middosage of conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each conduritol A group were more than those in the model group.
    CONCLUSIONS:
    Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.8446 mL 34.2231 mL 68.4463 mL 136.8925 mL 171.1157 mL
    5 mM 1.3689 mL 6.8446 mL 13.6893 mL 27.3785 mL 34.2231 mL
    10 mM 0.6845 mL 3.4223 mL 6.8446 mL 13.6893 mL 17.1116 mL
    50 mM 0.1369 mL 0.6845 mL 1.3689 mL 2.7379 mL 3.4223 mL
    100 mM 0.0684 mL 0.3422 mL 0.6845 mL 1.3689 mL 1.7112 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4-O-异亚丙基莽草酸; 3,4-O-Isopropylidene shikimic acid CFN99852 183075-03-8 C10H14O5 = 214.2 5mg QQ客服：2056216494
    3-O-咖啡酰莽草酸; 3-O-Caffeoylshikimic acid CFN92951 180981-12-8 C16H16O8 = 336.29 5mg QQ客服：1457312923
    4-O-咖啡酰莽草酸; 4-O-Caffeoylshikimic acid CFN92952 180842-65-3 C16H16O8 = 336.29 5mg QQ客服：215959384
    5-O-咖啡酰莽草酸; 5-O-Caffeoylshikimic acid CFN92950 73263-62-4 C16H16O8 = 336.29 10mg QQ客服：1457312923
    腐殖酸钠; Humic acid sodium salt CFN99794 68131-04-4 C9H8O4Na2 = 226.14 20mg QQ客服：1413575084
    去氧野艽霉素盐酸盐; Deoxynojirimycin hydrochloride CFN90484 73285-50-4 C6H14ClNO4 = 199.6 5mg QQ客服：2056216494
    环己五醇, L-栎醇; vibo-Quercitol CFN98778 488-76-6 C6H12O5 = 164.2 20mg QQ客服：215959384
    肌醇; Inositol CFN91718 87-89-8 C6H12O6 = 180.16 20mg QQ客服：2159513211
    (E)-1-甲氧基-2-O-(p-香豆酰)-myo-肌醇; (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol CFN95609 1391715-18-6 C16H20O8 = 340.3 20mg QQ客服：2159513211
    D-松醇; D-Pinitol CFN99044 10284-63-6 C7H14O6 = 194.2 20mg QQ客服：1457312923

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