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  • D-松醇

    D-Pinitol

    D-松醇
    产品编号 CFN99044
    CAS编号 10284-63-6
    分子式 = 分子量 C7H14O6 = 194.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The barks of Acacia nilotica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    D-松醇 CFN99044 10284-63-6 10mg QQ客服:2159513211
    D-松醇 CFN99044 10284-63-6 20mg QQ客服:2159513211
    D-松醇 CFN99044 10284-63-6 50mg QQ客服:2159513211
    D-松醇 CFN99044 10284-63-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kazusa DNA Research Institute (Japan)
  • University of Sao Paulo (Brazil)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Eastern Finland (Finland)
  • Sapienza University of Rome (Italy)
  • Kitasato University (Japan)
  • Universidad Veracuzana (Mexico)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Toronto (Canada)
  • University of Beira Interior (Portugal)
  • Universidad Miguel Hernández (Spain)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Istanbul University (Turkey)
  • Sanford Burnham Medical Research Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • HortTechnology2016, 26(6):816-819
  • Front Pharmacol.2021, 12:770667.
  • Chemistry of Natural Compounds2020, 56,423-426
  • J Biochem Mol Toxicol.2017, 31(9)
  • Molecules.2021, 26(3):695.
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Nutr Metab (Lond).2019, 16:31
  • Molecules.2021, 26(9):2765.
  • Molecules.2018, 23(10):E2638
  • Industrial Crops and Products2022, 186:115298
  • Korean J Acupunct2020, 37:104-121
  • Food Chem.2020, 332:127412
  • International J of Green Pharmacy2019, 13(3)
  • Journal of Analytical Chemistry2017, 854-861
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • iScience.2020, 23(2):100849.
  • Toxicol In Vitro.2019, 59:161-178
  • Cancers (Basel).2021, 13(17):4327.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Int J Biol Macromol.2019, 126:653-661
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Oncol Lett.2020, 20(4):122.
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • ...
  • 生物活性
    Description: D-Pinitol is a safe nutrient to reduce calorie consumption when supplementing with creatine. It exerts anti-inflammatory, insulin-like activities; and inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells, which in turn protect bone loss from ovariectomy. It inhibits the activation of p38, JNK, and NF-κB, the expression of p53, Bcl-2, Bax and NF-kB proteins, and reduces focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity.
    Targets: GLUT | Src | NF-kB | FAK | p53 | Bcl-2/Bax
    In vitro:
    Int J Mol Sci. 2013 May 8;14(5):9790-802.
    D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways.[Pubmed: 23698767]
    Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been proven to induce tumor apoptosis and metastasis of cancer cells.
    METHODS AND RESULTS:
    In this study, we investigated the anti-metastasis effects of D-pinitol in human prostate cancer cells. We found that D-pinitol reduced the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. Treatment of prostate cancer cells with D-pinitol reduced mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerted its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-kB activation.
    CONCLUSIONS:
    Thus, D-pinitol may be a novel anti-metastasis agent for the treatment of prostate cancer metastasis.
    In vivo:
    Int Immunopharmacol. 2012 Mar;12(3):494-500.
    D-pinitol inhibits RANKL-induced osteoclastogenesis.[Pubmed: 22269833]
    Numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. D-pinitol, a 3-methoxy analogue of D-chiroinositol, was identified as an active principle in soy foods and legumes.
    METHODS AND RESULTS:
    Here we found that D-pinitol markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from bone marrow stromal cells and RAW264.7 macrophage cells. In addition, D-pinitol also reduced RANKL-induced p38 and JNK phosphorylation. Furthermore, RANKL-mediated increase of IKK, IκBα, and p65 phosphorylation and NF-κB-luciferase activity was inhibited by D-pinitol. However, D-pinitol did not affect the proliferation and differentiation of osteoblasts. In addition, D-pinitol also prevented the bone loss induced by ovariectomy in vivo.
    CONCLUSIONS:
    Our data suggest that D-pinitol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated RANKL-induced p38, JNK, and NF-κB activation, which in turn protect bone loss from ovariectomy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1493 mL 25.7467 mL 51.4933 mL 102.9866 mL 128.7333 mL
    5 mM 1.0299 mL 5.1493 mL 10.2987 mL 20.5973 mL 25.7467 mL
    10 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    50 mM 0.103 mL 0.5149 mL 1.0299 mL 2.0597 mL 2.5747 mL
    100 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-O-咖啡酰莽草酸; 5-O-Caffeoylshikimic acid CFN92950 73263-62-4 C16H16O8 = 336.29 10mg QQ客服:2932563308
    腐殖酸钠; Humic acid sodium salt CFN99794 68131-04-4 C9H8O4Na2 = 226.14 100mg QQ客服:1148253675
    去氧野艽霉素盐酸盐; Deoxynojirimycin hydrochloride CFN90484 73285-50-4 C6H14ClNO4 = 199.6 5mg QQ客服:2159513211
    环己五醇, L-栎醇; vibo-Quercitol CFN98778 488-76-6 C6H12O5 = 164.2 20mg QQ客服:1413575084
    肌醇; Inositol CFN91718 87-89-8 C6H12O6 = 180.16 20mg QQ客服:2159513211
    D-松醇; D-Pinitol CFN99044 10284-63-6 C7H14O6 = 194.2 20mg QQ客服:3257982914
    (-)-白雀木醇; L-Quebrachitol CFN90586 642-38-6 C7H14O6 = 194.18 5mg QQ客服:3257982914
    牛弥菜醇A; Conduritol A CFN98868 526-87-4 C6H10O4 = 146.1 10mg QQ客服:2932563308
    D-(-)-奎宁酸; D-(-)-Quinic acid CFN99930 77-95-2 C7H12O6 = 192.17 20mg QQ客服:3257982914
    莽草酸; Shikimic acid CFN99436 138-59-0 C7H10O5 = 174.2 20mg QQ客服:3257982914

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