Info: Read More
  • 中药标准品生产商,产品定制服务
  • 重楼皂苷II

    Polyphyllin II

    重楼皂苷II
    产品编号 CFN99953
    CAS编号 76296-72-5
    分子式 = 分子量 C44H70O16 = 855.02
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Steroids
    植物来源 The rhizomes of Paris yunnanensis Franch.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    重楼皂苷II CFN99953 76296-72-5 1mg QQ客服:2056216494
    重楼皂苷II CFN99953 76296-72-5 5mg QQ客服:2056216494
    重楼皂苷II CFN99953 76296-72-5 10mg QQ客服:2056216494
    重楼皂苷II CFN99953 76296-72-5 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Institute of Cancer Research (United Kingdom)
  • Tohoku University (Japan)
  • University of Malaya (Malaysia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Auburn University (USA)
  • Universite de Lille1 (France)
  • Universita' Degli Studi Di Cagliari (Italy)
  • National Cancer Institute (USA)
  • Rio de Janeiro State University (Brazil)
  • Aveiro University (Portugal)
  • Donald Danforth Plant Science Center (USA)
  • University of Hawaii Cancer Center (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Auckland (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Planta Med.2023, a-2192-2281.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Front Pharmacol.2021, 12:761922.
  • FASEB J.2019, 33(8):9685-9694
  • Life Sci.2023, 317:121458.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • J Ethnopharmacol.2023, 317:116789.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Biochem Pharmacol. 2020, 177:114014.
  • Molecules2022, 27(9):2827.
  • LWT2020, 110397
  • bioRxiv2021, 462065.
  • Front Pharmacol.2020, 11:566490.
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • J Pharm Biomed Anal.2023, 234:115570.
  • Food Chem. 2020, 320:126530
  • JAOCS2021, 98(7):779-794.
  • ScientificWorldJournal.2022, 2022:4806889.
  • Curr Eye Res.2018, 43(1):27-34
  • Int J Mol Sci.2018, 19(9):E2825
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Bio-protocol2018, 9(14):e3301
  • Univerzita Karlova2021, 20.500.11956.
  • ...
  • 生物活性
    Description: Polyphyllin II has hemolytic effect, the hemolytic mechanism in vitro may be related to the increase in intracellular osmotic pressure and rupture of erythrocytes by changing the anion channel transport activity, with glucose transporter 1 (GLUT1) as the major competitive interaction site.
    Targets: GLUT
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3623-9.
    Study on hemolytic mechanism of polyphyllin II.[Pubmed: 26983211]
    To study the hemolytic effect of Polyphyllin II (PP II) mediated by anion channel protein and glucose transporter 1 (GLUT1), in order to initially reveal its hemolytic mechanism in vitro.
    METHODS AND RESULTS:
    In the experiment, the spectrophotometric method was adopted to detect the hemolysis of PP II in vitro and the effect of anion channel-related solution and blocker, glucose channel-related inhibitor and multi-target drugs dehydroepiandrosterone (DHEA) and diazepam on the hemolysis of PP II. The scanning electron microscope and transmission electron microscope were used to observe the effect of PP II on erythrocyte (RBC) morphology. The results showed that PP II -processed blood cells were severely deformed into spherocytes, acanthocyturia and vesicae. According to the results of the PP II hemolysis experiment in vitro, the anion hypertonic solution LiCl, NaHCO3, Na2SO4 and PBS significantly inhibited the hemolysis induced by PP II (P < 0.05), while blockers NPPB and DIDS remarkably promoted it (P < 0.01). Hyperosmotic sodium chloride, fructose and glucose at specific concentrations notably antagonized the hemolysis induced by PP II (P < 0.05). The glucose channel inhibitor Cytochalasin B and verapamil remarkably antagonized the hemolysis induced by PP II (P < 0.01). The hemolysis induced by PP II could also be antagonized by 1 gmol x L(1) diazepam and 100 μmol x L(-1) DHEA pretreated for 1 min (P < 0.01).
    CONCLUSIONS:
    In conclusion, the hemolytic mechanism of PP II in vitro may be related to the increase in intracellular osmotic pressure and rupture of erythrocytes by changing the anion channel transport activity, with GLUT1 as the major competitive interaction site.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1696 mL 5.8478 mL 11.6956 mL 23.3913 mL 29.2391 mL
    5 mM 0.2339 mL 1.1696 mL 2.3391 mL 4.6783 mL 5.8478 mL
    10 mM 0.117 mL 0.5848 mL 1.1696 mL 2.3391 mL 2.9239 mL
    50 mM 0.0234 mL 0.117 mL 0.2339 mL 0.4678 mL 0.5848 mL
    100 mM 0.0117 mL 0.0585 mL 0.117 mL 0.2339 mL 0.2924 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    短葶山麦冬皂苷C; Liriope muscari baily saponins C CFN90194 87480-46-4 C44H70O14 = 855.02 20mg QQ客服:215959384
    麦冬皂苷D'; Ophiopogonin D' CFN90503 65604-80-0 C44H70O16 = 855.02 10mg QQ客服:2159513211
    纤细薯蓣皂苷; Gracillin CFN98537 19083-00-2 C45H72O17 = 885.04 20mg QQ客服:2056216494
    重楼皂苷D; Polyphyllin D CFN90255 50773-41-6 C44H70O16 = 855.02 20mg QQ客服:2056216494
    薯蓣皂甙;薯蓣皂苷; Dioscin CFN99516 19057-60-4 C45H72O16 = 869.05 20mg QQ客服:2056216494
    重楼皂苷II; Polyphyllin II CFN99953 76296-72-5 C44H70O16 = 855.02 5mg QQ客服:1413575084
    重楼皂苷E; Polyphyllin E CFN90446 76296-73-6 C51H82O20 = 1015.18 5mg QQ客服:3257982914
    重楼皂苷F; Polyphyllin F CFN90447 76296-74-7 C51H82O20 = 1015.18 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产