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  • 薯蓣皂甙;薯蓣皂苷

    Dioscin

    薯蓣皂甙;薯蓣皂苷
    产品编号 CFN99516
    CAS编号 19057-60-4
    分子式 = 分子量 C45H72O16 = 869.05
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The rhizomes of Dioscorea Zingiberensis C.H.Wright.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    薯蓣皂甙;薯蓣皂苷 CFN99516 19057-60-4 10mg QQ客服:2159513211
    薯蓣皂甙;薯蓣皂苷 CFN99516 19057-60-4 20mg QQ客服:2159513211
    薯蓣皂甙;薯蓣皂苷 CFN99516 19057-60-4 50mg QQ客服:2159513211
    薯蓣皂甙;薯蓣皂苷 CFN99516 19057-60-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Medical Research Institute (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Mahidol University (Thailand)
  • University of Perugia (Italy)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Monash University Malaysia (Malaysia)
  • Donald Danforth Plant Science Center (USA)
  • University of Eastern Finland (Finland)
  • National Cancer Institute (USA)
  • The Ohio State University (USA)
  • Complutense University of Madrid (Spain)
  • University of Auckland (New Zealand)
  • University of Hertfordshire (United Kingdom)
  • University of Illinois at Chicago (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 206:73-77
  • Phytomedicine.2019, 55:229-237
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Life (Basel).2021, 11(12):1399.
  • Wageningen University & Research2018, January 2018
  • J Clin Med.2019, 8(10):E1664
  • J of Dentistry & Oral Health2019, 2641-1962
  • BMC Complement Altern Med.2019, 19(1):11
  • Universidade Estadual Paulista2017, 11449
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Journal of Ginseng Research2021, 15 June.
  • Appl. Sci.2020, 10(16),5482.
  • Appl. Sci. 2021, 11(23),11099.
  • Biofactors.2018, 44(2):168-179
  • Fitoterapia.2022, 157:105130.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Antioxidants (Basel).2020, 9(6):466.
  • Neurochem Res.2021, s11064-021-03449-0
  • BMC Plant Biol.2018, 18(1):122
  • Int J Biol Macromol.2021, 199:189-200.
  • Nutrients.2018, 10(7)
  • ...
  • 生物活性
    Description: Dioscin has anti-obesity, antineoplastic, anti-cancer, anti-inflammatory, uricosuric and nephroprotective actions, it can potentially contribute to treatments for inflammatory diseases and atherosclerosis. Dioscin clearly protected PC12 cells and primary cortical neurons against OGD/R insult and significantly prevented cerebral I/R injury. It inhibited AMPK/MAPK pathway and regulated VEGFR2 and AKT/MAPK signaling pathways.
    Targets: NF-kB | AP-1 | STAT | LTR | TNF-α | ERK | JNK | AMPK | VEGFR | Src | FAK | Akt | p38MAPK
    In vitro:
    Biochimie. 2015 Mar;110:62-72.
    Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1and EL expression via the NF-κB pathway.[Pubmed: 25577996]
    The modulation of adhesion molecule expression and the reduction of aberrant leukocyte adhesion to the endothelium are attractive approaches for treating inflammation-related vascular complications, including atherosclerosis. Dioscin has a variety of biological activities including anti-inflammatory activity. However, the molecular mechanisms behind dioscin's anti-inflammatory effects are not fully understood.
    METHODS AND RESULTS:
    In this study, we investigated the molecular mechanism involved in the effects of dioscin on inflammatory mediators in tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). In vitro, dioscin decreased monocyte adhesion to TNF-α-treated HUVECs by reducing vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) expression and inhibiting endothelial lipase (EL) expression in TNF-α-treated HUVECs and macrophages by blocking the nuclear factor-κB (NF-κB) pathway.
    CONCLUSIONS:
    Thus, dioscin might inhibit inflammation by interrupting the NF-κB signaling pathway and could potentially contribute to treatments for inflammatory diseases and atherosclerosis.
    J Nat Prod. 2013 May 24;76(5):909-14.
    Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition.[Pubmed: 23621869 ]
    The purpose of this study was to investigate the ameliorating effect of dioscin (1) on multidrug resistance (MDR) in adriamycin (ADR)-resistant erythroleukemic cells (K562/adriamycin, K562/ADR) and to clarify the molecular mechanisms involved.
    METHODS AND RESULTS:
    High levels of multidrug resistance 1 (MDR1) mRNA and protein and reduced ADR retention were found in K562/ADR cells compared with parental cells (K562). Dioscin (1), a constituent of plants in the genus Discorea, significantly inhibited MDR1 mRNA and protein expression and MDR1 promoter and nuclear factor κ-B (NF-κB) activity in K562/ADR cells. MDR1 mRNA and protein suppression resulted in the subsequent recovery of intracellular drug accumulation. Additionally, inhibitor κB-α (IκB-α) degradation was inhibited by 1. Dioscin (1) reversed ADR-induced MDR by down-regulating MDR1 expression by a mechanism that involves the inhibition of the NF-κB signaling pathway.
    CONCLUSIONS:
    These findings provide evidence to support the further investigation of the clinical application of dioscin (1) as a chemotherapy adjuvant.
    In vivo:
    Free Radic Biol Med. 2015 Mar 12.
    Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition.[Pubmed: 25772012]
    We previously reported the promising effect of dioscin against hepatic ischemia/reperfusion (I/R) injury, but its effect on cerebral I/R injury remains unknown.
    METHODS AND RESULTS:
    In this work, an in vitro oxygen-glucose deprivation and reoxygenation (OGD/R) model and an in vivo middle cerebral artery occlusion (MCAO) model were used. The results indicated that dioscin clearly protected PC12 cells and primary cortical neurons against OGD/R insult and significantly prevented cerebral I/R injury. Further research demonstrated that dioscin-induced neuroprotection was accompanied by a significant inhibition in the expression and the nuclear to cytosolic translocation of HMGB-1, reflected by decreased TLR4 expression. Blockade of the TLR4/MyD88/TRAF6 signaling pathway by dioscin inhibited NF-κB and AP-1 transcriptional activities, MAPK and STAT3 phosphorylation, and pro-inflammatory cytokine responses, and upregulated the levels of anti-inflammatory factors. In addition, small interfering RNA (siRNA) and overexpressed genes of HMGB-1 and TLR4 were applied in in vitro experiments, respectively, and the results further confirmed that dioscin showed an efficient neuroprotection because of its inhibiting effects on HMGB-1/TLR4 signaling and subsequent suppressing inflammation.
    CONCLUSIONS:
    These findings provide new insights that will aid in elucidating the effect of dioscin against cerebral I/R injury and support the development of dioscin as a potential treatment for ischemic stroke.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1507 mL 5.7534 mL 11.5068 mL 23.0136 mL 28.767 mL
    5 mM 0.2301 mL 1.1507 mL 2.3014 mL 4.6027 mL 5.7534 mL
    10 mM 0.1151 mL 0.5753 mL 1.1507 mL 2.3014 mL 2.8767 mL
    50 mM 0.023 mL 0.1151 mL 0.2301 mL 0.4603 mL 0.5753 mL
    100 mM 0.0115 mL 0.0575 mL 0.1151 mL 0.2301 mL 0.2877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    短葶山麦冬皂苷C; Liriope muscari baily saponins C CFN90194 87480-46-4 C44H70O14 = 855.02 20mg QQ客服:215959384
    麦冬皂苷D'; Ophiopogonin D' CFN90503 65604-80-0 C44H70O16 = 855.02 10mg QQ客服:1457312923
    纤细薯蓣皂苷; Gracillin CFN98537 19083-00-2 C45H72O17 = 885.04 20mg QQ客服:2056216494
    重楼皂苷D; Polyphyllin D CFN90255 50773-41-6 C44H70O16 = 855.02 20mg QQ客服:3257982914
    薯蓣皂甙;薯蓣皂苷; Dioscin CFN99516 19057-60-4 C45H72O16 = 869.05 20mg QQ客服:2159513211
    重楼皂苷II; Polyphyllin II CFN99953 76296-72-5 C44H70O16 = 855.02 5mg QQ客服:2056216494
    重楼皂苷E; Polyphyllin E CFN90446 76296-73-6 C51H82O20 = 1015.18 5mg QQ客服:1457312923
    重楼皂苷F; Polyphyllin F CFN90447 76296-74-7 C51H82O20 = 1015.18 5mg QQ客服:215959384

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