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  • 纤细薯蓣皂苷

    Gracillin

    纤细薯蓣皂苷
    产品编号 CFN98537
    CAS编号 19083-00-2
    分子式 = 分子量 C45H72O17 = 885.04
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Dioscorea opposita Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    纤细薯蓣皂苷 CFN98537 19083-00-2 10mg QQ客服:1413575084
    纤细薯蓣皂苷 CFN98537 19083-00-2 20mg QQ客服:1413575084
    纤细薯蓣皂苷 CFN98537 19083-00-2 50mg QQ客服:1413575084
    纤细薯蓣皂苷 CFN98537 19083-00-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Donald Danforth Plant Science Center (USA)
  • Heidelberg University (Germany)
  • University of Dicle (Turkey)
  • University of Madras (India)
  • Medizinische Universit?t Wien (Austria)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Wageningen University (Netherlands)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Istanbul University (Turkey)
  • Texas A&M University (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Universidade de Franca (Brazil)
  • Universidade Católica Portuguesa (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2022, 27(7):2093.
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Phytomedicine.2019, 61:152813
  • J Biomol Struct Dyn.2023, 1-21.
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Int J Mol Sci.2022, 23(20):12516.
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Mol Neurobiol.2022, 02873-9.
  • Horticulturae2022, 8(10), 975.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Plants (Basel).2021, 10(11):2317.
  • Int J Mol Sci.2020, 21(24):9369.
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Cells.2022, 11(8), 1311.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Pharmacogn J.2022, 14(2):350-357
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Mol Cells.2015, 38(9):765-72
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • ...
  • 生物活性
    Description: Gracillin has anti-tumor activity, can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.
    Targets: Bcl-2/Bax | Antifection
    In vitro:
    Pharmazie. 2015 Mar;70(3):199-204.
    Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.[Pubmed: 25980181]
    Gracillin, a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica has been reported to exert antitumor activity.
    METHODS AND RESULTS:
    In the present study, we investigated the anticancer activity of gracillin against HL60 cells, and evaluated the possible mechanism involved in its antineoplastic action. The cell proliferation was evaluated by cell counting Kit-8 (CCK-8) assay, gracillin inhibited the growth of HL60 cells in a time- and concentration-dependent manner. Flow cytometry was used to analyze the cell cycle distribution whereas Annexin V-FITC/PI flow cytometry analysis was carried out to confirm apoptosis induced by gracillin, Our results demonstrated that gracillin could induce cell cycle arrest of G1 and apoptosis in HL60 cells. Furthermore, based on the biochemical methods, induction of oxidative stress by gracillin was indicated by increased the content of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity. In addition, real time-PCR verified the expression of apoptosis-related genes, the mRNA level of Bcl-2 was decreased dramatically, while Bax was remarkably increased by gracillin.
    CONCLUSIONS:
    Taken together, gracillin could induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1299 mL 5.6495 mL 11.2989 mL 22.5978 mL 28.2473 mL
    5 mM 0.226 mL 1.1299 mL 2.2598 mL 4.5196 mL 5.6495 mL
    10 mM 0.113 mL 0.5649 mL 1.1299 mL 2.2598 mL 2.8247 mL
    50 mM 0.0226 mL 0.113 mL 0.226 mL 0.452 mL 0.5649 mL
    100 mM 0.0113 mL 0.0565 mL 0.113 mL 0.226 mL 0.2825 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    短葶山麦冬皂苷C; Liriope muscari baily saponins C CFN90194 87480-46-4 C44H70O14 = 855.02 20mg QQ客服:2159513211
    麦冬皂苷D'; Ophiopogonin D' CFN90503 65604-80-0 C44H70O16 = 855.02 10mg QQ客服:2159513211
    纤细薯蓣皂苷; Gracillin CFN98537 19083-00-2 C45H72O17 = 885.04 20mg QQ客服:2056216494
    重楼皂苷D; Polyphyllin D CFN90255 50773-41-6 C44H70O16 = 855.02 20mg QQ客服:3257982914
    薯蓣皂甙;薯蓣皂苷; Dioscin CFN99516 19057-60-4 C45H72O16 = 869.05 20mg QQ客服:215959384
    重楼皂苷II; Polyphyllin II CFN99953 76296-72-5 C44H70O16 = 855.02 5mg QQ客服:215959384
    重楼皂苷E; Polyphyllin E CFN90446 76296-73-6 C51H82O20 = 1015.18 5mg QQ客服:2056216494
    重楼皂苷F; Polyphyllin F CFN90447 76296-74-7 C51H82O20 = 1015.18 5mg QQ客服:215959384

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