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  • 连翘脂素

    Phillygenin

    连翘脂素
    产品编号 CFN90511
    CAS编号 487-39-8
    分子式 = 分子量 C21H24O6 = 372.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Forsythia suspensa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    连翘脂素 CFN90511 487-39-8 10mg QQ客服:2932563308
    连翘脂素 CFN90511 487-39-8 20mg QQ客服:2932563308
    连翘脂素 CFN90511 487-39-8 50mg QQ客服:2932563308
    连翘脂素 CFN90511 487-39-8 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Colorado State University (USA)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • FEBS Lett.2015, 589(1):182-7
  • FEMS Microbiol Lett.2017, 364(11)
  • Molecules.2016, 21(10)
  • Molecules.2019, 24(11):E2044
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Phytomedicine.2015, 22(14):1262-8
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Front Pharmacol.2022, 13:919230.
  • Institute of Food Science & Technology2021, 18 December.
  • Nat Prod Sci.2019, 25(3):238
  • J of Essential Oil Research2019, 1677272
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Int J Mol Sci.2021, 22(16):8641.
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Int J Mol Sci.2021, 22(19):10405.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • J. of Agricultural Science2015, 1916-9760
  • Phytochemistry.2017, 141:162-170
  • Molecules.2019, 24(17):E3127
  • Phytother Res.2019, 33(7):1784-1793
  • Cosmetics2021, 8(3),91.
  • ...
  • 生物活性
    Description: Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(50) values.
    Targets: NO
    In vitro:
    Eur J Drug Metab Pharmacokinet . 2013 Sep;38(3):201-7.
    Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies[Pubmed: 23564502]
    Abstract The research group has been dedicated to the study of Fructus Forsythiae which was used widely in traditional Chinese medicines. And some research results have been accepted in Chinese Pharmacopeia. In a recent study, phillygenin was found to be a potential "metabolite" of phillyrin and the effective material of phillyrin may be changed according to the in vivo pharmacokinetic process. Therefore, a sensitive, specific, accurate, and reproducible reversed phase HPLC method for the determination of phillygenin in rat plasma was developed. Separation was achieved on a Hypersil ODS C18 column with UV detection at 277 nm. The good linear calibration curves ranged from 0.039 to 20 μg/mL with the limit of quantification estimated as 0.026 μg/mL. The intra- and inter-day precisions were in the range of 98-103 %. The average recoveries of phillygenin were 90.54, 92.47, and 92.15 % for phillygenin of 0.156, 1.25, and 10.0 μg/mL. And the Ruggedness of HPLC method was evaluated. The analytical method was also successfully applied to the pharmacokinetic study of phillygenin in rat for the first time. A rapid distribution was observed from the plasma concentration-time curves, and was followed by a quick elimination for phillygenin. The mean t 1/2z was 6.02, 5.62, and 5.79 min for 1.4, 2.8, and 5.6 mg/kg, respectively. The AUC (0-t) increased linearly from 166.29 to 332.48 mg/L min. All results indicated that, in the range of the doses examined, the pharmacokinetics of phillygenin in rat was based on first-order kinetics.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6852 mL 13.4261 mL 26.8521 mL 53.7043 mL 67.1303 mL
    5 mM 0.537 mL 2.6852 mL 5.3704 mL 10.7409 mL 13.4261 mL
    10 mM 0.2685 mL 1.3426 mL 2.6852 mL 5.3704 mL 6.713 mL
    50 mM 0.0537 mL 0.2685 mL 0.537 mL 1.0741 mL 1.3426 mL
    100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.537 mL 0.6713 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:3257982914
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:1148253675
    (-)-松脂醇; (-)-Pinoresinol CFN92287 81446-29-9 C20H22O6 = 358.4 5mg QQ客服:1148253675
    (-)-丁香树脂酚; (-)-Syringaresinol CFN92500 6216-81-5 C22H26O8 = 418.4 10mg QQ客服:1413575084
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:2932563308
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:2159513211
    (-)-丁香树脂酚-4-O-beta-D-呋喃芹糖基-(1→2)-beta-D-吡喃葡萄糖苷; (-)-Syringaresinol 4-(2''-apiosylglucoside) CFN99504 136997-64-3 C33H44O17 = 712.69 20mg QQ客服:1148253675
    (+)-表松脂酚; (+)-Epipinoresinol CFN92288 24404-50-0 C20H22O6 = 358.4 5mg QQ客服:3257982914
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:2932563308
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:1148253675

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