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  • Kobusin

    Kobusin

    Kobusin
    产品编号 CFN89280
    CAS编号 36150-23-9
    分子式 = 分子量 C21H22O6 = 370.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The barks of Zanthoxylum rhetsa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Kobusin CFN89280 36150-23-9 1mg QQ客服:2932563308
    Kobusin CFN89280 36150-23-9 5mg QQ客服:2932563308
    Kobusin CFN89280 36150-23-9 10mg QQ客服:2932563308
    Kobusin CFN89280 36150-23-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyoto University (Japan)
  • VIT University (India)
  • Utrecht University (Netherlands)
  • Institute of Chinese Materia Medica (China)
  • Gyeongsang National University (Korea)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Bordeaux (France)
  • University of East Anglia (United Kingdom)
  • University of Stirling (United Kingdom)
  • Griffith University (Australia)
  • Medical University of Gdansk (Poland)
  • Michigan State University (USA)
  • University of Medicine and Pharmacy (Romania)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(11):6104.
  • PLoS One.2018, 13(3):e0193386
  • Food Chem.2021, 360:130063.
  • J Biomol Struct Dyn.2022, 1-21.
  • Antioxidants (Basel).2021, 10(10):1638.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Korean Journal of Pharmacognosy2014, 113-120
  • Front Neurosci.2019, 13:1091
  • Molecules.2021, 26(18):5665.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • J Pharm Biomed Anal.2017, 140:274-280
  • Int J Biol Macromol.2020, 169:342-351
  • Kor. J. Herbol.2019, 34(2):59-66
  • Environ Toxicol.2021, doi: 10.1002
  • Nat Commun.2021, 12(1):681.
  • The Korea Journal of Herbology2016, 29-35
  • Appl. Sci. 2021, 11(1),14.
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • South African J of Plant&Soil2018, 29-32
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • BMC Microbiol.2019, 19(1):78
  • ...
  • 生物活性
    Description: Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.
    Targets: NF-kB | NO | NOS | cAMP | CFTR | CaCCgie chloride channel | ATP
    In vitro:
    Molecules. 2016 May 24;21(6).
    Bioactive Constituents of Zanthoxylum rhetsa Bark and Its Cytotoxic Potential against B16-F10 Melanoma Cancer and Normal Human Dermal Fibroblast (HDF) Cell Lines.[Pubmed: 27231889 ]
    Zanthoxylum rhetsa is an aromatic tree, known vernacularly as "Indian Prickly Ash". It has been predominantly used by Indian tribes for the treatment of many infirmities like diabetes, inflammation, rheumatism, toothache and diarrhea.
    METHODS AND RESULTS:
    In this study, we identified major volatile constituents present in different solvent fractions of Z. rhetsa bark using GC-MS analysis and isolated two tetrahydrofuran lignans (yangambin and kobusin), a berberine alkaloid (columbamine) and a triterpenoid (lupeol) from the bioactive chloroform fraction. The solvent fractions and purified compounds were tested for their cytotoxic potential against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10) cells, using the MTT assay. All the solvent fractions and purified compounds were found to be non-cytotoxic to HDF cells. However, the chloroform fraction and kobusin exhibited cytotoxic effect against B16-F10 melanoma cells.
    CONCLUSIONS:
    The presence of bioactive lignans and alkaloids were suggested to be responsible for the cytotoxic property of Z. rhetsa bark against B16-F10 cells.
    J Ethnopharmacol. 2011 Nov 18;138(2):637-40.
    Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum.[Pubmed: 21982788 ]

    METHODS AND RESULTS:
    The chemical composition of the aerial parts of the Cape Verdean endemic shrub Artemisia gorgonum Webb (Asteraceae) was careful investigated, which led to the isolation and identification of six known furfuran lignans: eudesmin (1), magnolin (2), epimagnolin A (3), aschantin (4), kobusin (5), sesamin (6) and a flavone: artemetin (7). Compounds 1-7 were evaluated in vitro for their cytotoxicity in a screening panel consisting of various mammalian tumor cell lines, for their antimalarial activity against chloroquine-resistant Plasmodium falciparum (FcB1 strain) and for their cytotoxicity against murine normal cells (CFU-GM). While no promising cytotoxicity against human tumor cells were noticed, marginal potency and selectivity was found for compounds 1-5 against murine colon 38. Besides, compounds 2-7 showed mild antiplasmodial activities, 6 and 7 being the most active compounds (IC(50) 3.37 and 3.50 μg/ml respectively) without noticeable toxicity on mammalian normal cells.
    CONCLUSIONS:
    This is the first report of antiplasmodial activity for furfuran lignans and the first isolation of 1-7 from Artemisia gorgonum.
    Phytother Res. 2010 May;24(5):748-53.
    Suppression of inducible nitric oxide synthase expression by furfuran lignans from flower buds of Magnolia fargesii in BV-2 microglial cells.[Pubmed: 19943243]
    Activated microglia produces diverse neurotoxic factors such as nitric oxide (NO) and tumor necrosis factor-alpha that serve as apoptotic inducers resulting in various neurodegenerative diseases. The inhibition of microglia-derived NO production by inducible nitric oxide synthase (iNOS) has been reported to be beneficial in retarding neurodegenerative disorders.
    METHODS AND RESULTS:
    Three active lignans have been isolated from the flower buds of Magnolia fargesii by the bioassay-guided fractionation using lipopolysaccharide (LPS)-activated BV-2 microglial cell culture system. The structures of them were identified as kobusin (1), aschantin (2) and fargesin (3) by the analyses of spectroscopic data. They inhibited the production of NO by activated microglia. Their IC(50) values were 21.8 +/- 3.7, 14.8 +/- 2.5 and 10.4 +/- 2.8 microg/mL, respectively. They suppressed LPS-induced NF-kappaB activation and the expression of iNOS protein and mRNA. Furthermore, they showed scavenging activity of neurotoxic peroxynitrite that can be produced by NO and superoxide anion.
    CONCLUSIONS:
    These results imply that lignans from Magnolia fargesii might be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6998 mL 13.4989 mL 26.9978 mL 53.9957 mL 67.4946 mL
    5 mM 0.54 mL 2.6998 mL 5.3996 mL 10.7991 mL 13.4989 mL
    10 mM 0.27 mL 1.3499 mL 2.6998 mL 5.3996 mL 6.7495 mL
    50 mM 0.054 mL 0.27 mL 0.54 mL 1.0799 mL 1.3499 mL
    100 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.6749 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:3257982914
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:2932563308
    (-)-丁香树脂酚-4-O-beta-D-呋喃芹糖基-(1→2)-beta-D-吡喃葡萄糖苷; (-)-Syringaresinol 4-(2''-apiosylglucoside) CFN99504 136997-64-3 C33H44O17 = 712.69 20mg QQ客服:1148253675
    (+)-表松脂酚; (+)-Epipinoresinol CFN92288 24404-50-0 C20H22O6 = 358.4 5mg QQ客服:1148253675
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:2932563308
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:1148253675
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:3257982914
    连翘脂素; Phillygenin CFN90511 487-39-8 C21H24O6 = 372.41 20mg QQ客服:2159513211
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:2159513211
    (+)-杜仲树脂酚双葡萄糖苷; (+)-Mediresinol Di-O-beta-D-glucopyranoside CFN91840 88142-63-6 C33H44O17 = 712.7 5mg QQ客服:1413575084

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