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  • 刺五加苷D

    Eleutheroside D

    刺五加苷D
    产品编号 CFN98510
    CAS编号 79484-75-6
    分子式 = 分子量 C34H46O18 = 742.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The root barks of Eleutherococcus senticosus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    刺五加苷D CFN98510 79484-75-6 1mg QQ客服:1413575084
    刺五加苷D CFN98510 79484-75-6 5mg QQ客服:1413575084
    刺五加苷D CFN98510 79484-75-6 10mg QQ客服:1413575084
    刺五加苷D CFN98510 79484-75-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Molecular Liquids2021, 334:116014.
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • HIV Med.2021, 22(8):690-704.
  • Int J Mol Sci.2018, 19(2)
  • Int J Oncol.2016, 49(4):1497-504
  • Oxid Med Cell Longev2020, 12
  • Food Analytical Methods2020, 1-10
  • J Pharm Biomed Anal.2016, 129:50-59
  • J Colloid Interface Sci.2022, 622:298-308.
  • Int J Mol Sci.2019, 20(16):E4015
  • J Food Composition and Analysis2022, 104417.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Life (Basel).2021, 11(12):1399.
  • Planta Med.2019, 85(4):347-355
  • Ann Transl Med.2019, 7(23):731
  • Agriculture2022, 12(2),227.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Pharmacogn J.2022, 14(2):350-357
  • New Journal of Chemistry2019, 43:12538-12547
  • Front Nutr.2021, 8: 687851.
  • Nutrients.2017, 10(1)
  • Antiviral Res.2021, 193:105142.
  • Plos One.2019, 15(2):e0220084
  • ...
  • 生物活性
    Description: Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
    In vivo:
    Chinese General Practice, 2009, 12(4):292-4.
    Protective Effect of Eleutheroside Preconditioning to Myocardial Ischemic Reperfusion Injury in Isolated Rats[Reference: WebLink]
    To investigate the protective effect of eleutherosid preconditioning to myocardial ischemic-reperfusion injury(IRI) in isolated rats and the dose-effect relationship between eleutheroside preconditioning and the myocardial protection.
    METHODS AND RESULTS:
    Male rat hearts,which were isolated and perfused with Langendorff apparatus,were randomly divided into 5 groups,6 in each.The isolated hearts were subjected to 25 min ischemia and then followed by 30 min reperfusion after 15min stabilization in control group(C).In the eleutheroside preconditioned groups(P1,P2,P3,P4),the hearts were perfused with eleutheroside(30 mg/kg,40 mg/kg,60 mg/kg and 80mg/kg,respectively) for 10 min before ischemia-reperfusion.Left ventricular developed pressure(LVDP),left ventricular end diastolic pressure(LVEDP),maximal rate of increase /decrease of left ventricular pressure(±dp/d tMax),and coronary blood flow(CF) were monitored continuously.And an arrhythmias score was used to quantify the arrhythmias during reperfusion.After reperfusing 30 min reperfusion,as compared with group C,① P2 and P3 groups might increase LVDP、+dp/dtMax and-dp/dtMax more significantly(P0.05);②P2 and P3 groups might raise CF more significantly(P0.01);③P2 and P3 groups had lower arrhythmia scores(P0.05).
    CONCLUSIONS:
    Eleutheroside preconditioning has a dose-effect on IRI of isolated rat hearts.
    Evid Based Complement Alternat Med . 2013;2013:934183.
    Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice[Pubmed: 23690865]
    Abstract Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart. However, it is unknown whether it ameliorates insulin resistance and reduces hyperglycemia in diabetes. This study investigated the effect of EE-containing ES extracts, as well as EE, on hyperglycemia and insulin resistance in db/db mice. EE increased the insulin-provoked glucose uptake in C2C12 myotubes. Moreover, EE improved TNF- α -induced suppression of glucose uptake in 3T3-L1 adipocytes. Five-week-old db/db mice were fed a diet consisting of ES extract or EE for 5 weeks. Both were effective in improving serum lipid profiles and significantly decreased blood glucose and serum insulin levels. ES and EE supplementation effectively attenuated HOMA-IR. Glucose tolerance and insulin tolerance tests showed that EE increased insulin sensitivity. Immunohistochemical staining indicated that ES and EE protected pancreatic alpha and beta cells from diabetic damage. In addition, ES and EE improved hepatic glucose metabolism by upregulating glycolysis and downregulating gluconeogenesis in obese type 2 diabetic mice. These data suggest that EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization. The beneficial effects of EE may provide an effective and powerful strategy to alleviate diabetes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3464 mL 6.732 mL 13.464 mL 26.928 mL 33.6601 mL
    5 mM 0.2693 mL 1.3464 mL 2.6928 mL 5.3856 mL 6.732 mL
    10 mM 0.1346 mL 0.6732 mL 1.3464 mL 2.6928 mL 3.366 mL
    50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5386 mL 0.6732 mL
    100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.2693 mL 0.3366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:2932563308
    (+)-杜仲树脂酚双葡萄糖苷; (+)-Mediresinol Di-O-beta-D-glucopyranoside CFN91840 88142-63-6 C33H44O17 = 712.7 5mg QQ客服:1148253675
    辛夷脂素; Fargesin CFN98174 31008-19-2 C21H22O6 = 370.39 20mg QQ客服:215959384
    细辛脂素; Asarinin CFN90628 133-05-1 C20H18O6 = 354.35 20mg QQ客服:1148253675
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:2159513211
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:215959384
    (-)-松脂醇; (-)-Pinoresinol CFN92287 81446-29-9 C20H22O6 = 358.4 5mg QQ客服:215959384
    (-)-丁香树脂酚; (-)-Syringaresinol CFN92500 6216-81-5 C22H26O8 = 418.4 10mg QQ客服:2932563308
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:3257982914
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:1148253675

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