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  • (-)-细辛脂素

    (-)-Asarinin

    (-)-细辛脂素
    产品编号 CFN90144
    CAS编号 133-04-0
    分子式 = 分子量 C20H18O6 = 354.35
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Lignans
    植物来源 The herbs of Asarum sieboldii Miq.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-细辛脂素 CFN90144 133-04-0 10mg QQ客服:215959384
    (-)-细辛脂素 CFN90144 133-04-0 20mg QQ客服:215959384
    (-)-细辛脂素 CFN90144 133-04-0 50mg QQ客服:215959384
    (-)-细辛脂素 CFN90144 133-04-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Michigan State University (USA)
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  • Lodz University of Technology (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2020, 9(11):1535.
  • Front Immunol.2020, 11:598556.
  • J Sep Sci.2019, 42(21):3352-3362
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • RSC Adv.2018, 32621-32636
  • Plant Foods Hum Nutr.2020, 10.1007
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • Front Pharmacol.2021, 12:770667.
  • Phytochemistry Letters2021, 43:80-87.
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Phytother Res.2018, 32(5):923-932
  • Int J Mol Sci.2022, 23(11):6104.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Sci Rep.2020, 10:4495(2020)
  • Chem Biol Interact.2020, 328:109200.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Korean J Environ Agric.2018, 37(4):260-267
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Phytomedicine.2020, 153440.
  • Molecules.2020, 25(11):2599.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Biomedicines.2022, 10(3):583.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • ...
  • 生物活性
    Description: Asarinin, a mammalian lignan precursor, has immunosuppression activity in vitro. Asarinin can decrease peripheral blood concentration of interleukin (IL)-12 and inhibit the expression of Toll-like receptor 4 (TLR4) and chemokine (C-X-C motif) receptor 3 (CXCR3), which means asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival.
    Targets: IL Receptor | IFN-γ | CXCR | TLR
    In vitro:
    Chinese Journal of Cardiology, 2003, 31(6):444-7.
    Experimental study of the effects of Asarinin on immunosuppression activity in vitro.[Reference: WebLink]
    To test the extract of Asarum heterotropides called Asarinin in the immunosuppression activity in vitro and compared with cyclosporine A(CsA).
    METHODS AND RESULTS:
    Cardiomyocytes of adult wistar rats and spleen cells of adult SD rats were separated. 0.1 ml of the cardiomyocytes(2×10~(6)/ml) as stimulate cells and 0.1 ml of spleen cells(1×10~(7)/ml) as response cells were cultured in 96 culture plates. The model of rejection reaction in vitro was set up. Then the 0.1 ml serum including Asarinin was given to culture plates, the inhibition rate of lymphocyte transformation was investigated with MTT after 108 hours and IL-2、INF-#gamma#、IL-4 were detected with ELISA. Asarinin inhibited the lymphocyte transformation (inhibition rate 60.37%) in vitro.
    CONCLUSIONS:
    Compared with positive control group, it significantly decreased IL-2(69.11±17.47 pg/ml vs 160.44±19.79 pg/ ml, P<0.01)、INF-#gamma#(183.11± 95.24 pg/ml vs 521.89± 133.18 pg/ml, P<0.01) and increased IL-4(53.14±11.80 pg/ml vs 14.44± 4.21 pg/ml, P<0.01)in culture plates.
    In vivo:
    Transplant Proc. 2015 Mar;47(2):545-8.
    The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation.[Pubmed: 25769604]
    The objective of this study was to study the mechanism of the anti-rejection effect of Asarinin in rats that underwent cardiac allograft implantation.
    METHODS AND RESULTS:
    Hearts from Wistar rats were transplanted into the abdominal cavity of Sprague Dawley rats (SD rats) 64 SD rats received either cyclosporin A (CsA), Asarinin, or demi-dose of cyclosporine A and Asarinin through oral administration. On the seventh day post-transplantation, the expression of Toll-like receptor 4 (TLR4), chemokine (C-X-C motif) receptor 3 (CXCR3) in myocardium, and the level of interleukin (IL)-12 in the peripheral blood were analyzed 7 days after transplantation. The survival time in 3 groups (CsA group, Asarinin group, and semi-dose CsA group) prolonged (P < .01), the microscope myocardial histopathology in 3 groups (CsA group, Asarinin group and semi-dose CsA group) relieved, the expression of TLR4 and CXCR3 in 3 groups was significantly decreased (P < .01) when compared with the control group. The level of IL-12 decreased remarkably (P < .05) in the 3 groups when compared with the control group.
    CONCLUSIONS:
    The combined data suggested that Asarinin decreased peripheral blood concentration of IL-12 and inhibited the expression of TLR4 and CXCR3, which means Asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8221 mL 14.1103 mL 28.2207 mL 56.4414 mL 70.5517 mL
    5 mM 0.5644 mL 2.8221 mL 5.6441 mL 11.2883 mL 14.1103 mL
    10 mM 0.2822 mL 1.411 mL 2.8221 mL 5.6441 mL 7.0552 mL
    50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.1288 mL 1.411 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-表松脂酚; (+)-Epipinoresinol CFN92288 24404-50-0 C20H22O6 = 358.4 5mg QQ客服:215959384
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:1148253675
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:2932563308
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:215959384
    连翘脂素; Phillygenin CFN90511 487-39-8 C21H24O6 = 372.41 20mg QQ客服:3257982914
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:1413575084
    (+)-杜仲树脂酚双葡萄糖苷; (+)-Mediresinol Di-O-beta-D-glucopyranoside CFN91840 88142-63-6 C33H44O17 = 712.7 5mg QQ客服:215959384
    辛夷脂素; Fargesin CFN98174 31008-19-2 C21H22O6 = 370.39 20mg QQ客服:3257982914
    细辛脂素; Asarinin CFN90628 133-05-1 C20H18O6 = 354.35 20mg QQ客服:1413575084
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:215959384

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