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  • Mahanine


    产品编号 CFN92199
    CAS编号 28360-49-8
    分子式 = 分子量 C23H25NO2 = 347.5
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The leaves of Murraya koenigii
    产品名称 产品编号 CAS编号 包装 QQ客服
    Mahanine CFN92199 28360-49-8 1mg QQ客服:2159513211
    Mahanine CFN92199 28360-49-8 5mg QQ客服:2159513211
    Mahanine CFN92199 28360-49-8 10mg QQ客服:2159513211
    Mahanine CFN92199 28360-49-8 20mg QQ客服:2159513211
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Kyung Hee University (Korea)
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  • Kyushu University (Japan)
  • Tohoku University (Japan)
  • University of Hull (United Kingdom)
  • University of Auckland (New Zealand)
  • Imperial College London (United Kingdom)
  • Siksha O Anusandhan University (India)
  • Ateneo de Manila University (Philippines)
  • University of Dicle (Turkey)
  • University of Bonn (Germany)
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  • ...
  • 生物活性
    Description: Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer.
    Targets: JAK | Src | STAT | ROS | Chk | CDK | Akt | PI3K | p53
    In vitro:
    Cancer Lett. 2014 Aug 28;351(1):81-90.
    Improved chemosensitivity in cervical cancer to cisplatin: synergistic activity of mahanine through STAT3 inhibition.[Pubmed: 24831030]
    Toxicity reduction of cisplatin is necessary for improved treatment of cancer.
    Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effective concentration ∼5-8 folds. Mahanine inhibited JAK1 and Src and subsequently promoted proteasome-mediated degradation of STAT3. This event was further enhanced in-combination with cisplatin and subsequently inhibited cancer cell migration.
    Collectively, our results revealed that mahanine may be a prospective agent to reduce the concentration of cisplatin in adjunct for the treatment of cancer and thereby decreasing its toxicity.
    Apoptosis. 2014 Jan;19(1):149-64.
    Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma.[Pubmed: 24052409]
    5-Fluorouracil (5-FU) alone or in combination with other drugs is the main basis of chemotherapeutic treatment in colorectal cancer although patients with microsatellite instability generally show resistance to 5-FU treatment.
    The present investigation is focussed on the mechanistic insight of a pure herbal carbazole alkaloid, Mahanine, as a single or in combination with 5-FU in colon cancer. We demonstrated that Mahanine-induced apoptosis involved reactive oxygen species (ROS)-mediated nuclear accumulation of PTEN and its interaction with p53/p73. Mahanine and 5-FU in combination exerted synergistic inhibitory effect on cell viability. This combination also enhanced ROS production, increased tumour suppressor proteins and suppressed chemo-migration.
    Taken together, our results revealed that Mahanine can be a potential chemotherapeutic agent with efficacy to reduce the concentration of toxic 5-FU in colon cancer.
    In vivo:
    Am J Cancer Res. 2014 Nov 19;4(6):629-47.
    Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme.[Pubmed: 25520856]
    The Electron transport chain (ETC) is responsible for oxidative phosphorylation-mediated mitochondrial respiration.
    Here we wanted to address the Mahanine-induced targeted pathways in glioblastoma multiforme (GBM) in the context of G0/G1 phase arrest and redox alteration. We have demonstrated Mahanine, as a novel mitochondrial complex-III inhibitor which induced G0/G1 phase arrest in GBM. This event was preceded by accumulation of intracellular ROS by the inhibition of mitochondrial ETC. The accumulated ROS induced DNA damage response (DDR), that mediated Chk1/Chk2 upregulation and activation which were essential factors for the G0/G1 arrest. NAC-mediated scavenging of ROS generation reduced the propensity of G0/G1 phase arrest in GBM cells by Mahanine. Knockdown of Chk1/Chk2 also affected the cell cycle inhibitory potential of Mahanine. During G0/G1 arrest, other hallmark proteins like, cyclin D1/cyclin D3, CDK4/CDK6 and CDC25A were also downregulated. The G0/G1 phase restriction property of Mahanine was also established in in vivo mice model. Mahanine-induced complex-III inhibition triggered enhanced ROS in hypoxia responsible for higher G0/G1 arrest. Furthermore, we demonstrated that Mahanine-treated G0/G1 arrested cells were less potent to form xenograft tumor in vivo. Additionally, they exhibited reduced ability to migrate and form intracellular tube-like structures. Moreover, they became susceptible to differentiate and astrocyte-like cells were generated from the epithelial lineage.
    Taken together, our results established that complex-III of ETC is one of the possible potential targets of Mahanine. This nontoxic chemotherapeutic molecule enhanced ROS production, induced cell cycle arrest and thereafter regressed GBM without effecting normal astrocytes.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8777 mL 14.3885 mL 28.777 mL 57.554 mL 71.9424 mL
    5 mM 0.5755 mL 2.8777 mL 5.7554 mL 11.5108 mL 14.3885 mL
    10 mM 0.2878 mL 1.4388 mL 2.8777 mL 5.7554 mL 7.1942 mL
    50 mM 0.0576 mL 0.2878 mL 0.5755 mL 1.1511 mL 1.4388 mL
    100 mM 0.0288 mL 0.1439 mL 0.2878 mL 0.5755 mL 0.7194 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    九里香碱; Murrayanine CFN91484 723-97-7 C14H11NO2 = 225.2 5mg QQ客服:1457312923
    Clausine E; Clausine E CFN91823 182261-83-2 C14H11NO3 = 241.2 5mg QQ客服:1457312923
    1,6-二羟基-9H-咔唑-3-甲醛; Clausine Z CFN97428 866111-14-0 C13H9NO3 = 227.2 5mg QQ客服:215959384
    1-羟基-6-甲氧基-9H-咔唑-3-甲醛; Clausine I CFN97800 182261-94-5 C14H11NO3 = 241.24 5mg QQ客服:2056216494
    2,8-二羟基-9H-咔唑-3-甲醛; Clauszoline M CFN97796 187110-72-1 C13H9NO3 = 227.22 5mg QQ客服:3257982914
    柯里九里香碱; Curryangine CFN92926 25488-37-3 C23H25NO = 331.45 5mg QQ客服:3257982914
    Murrayamine E; Murrayamine E CFN92927 172617-68-4 C23H25NO2 = 347.45 5mg QQ客服:2159513211
    柯九里香甲碱; Koenigicine CFN70319 24123-92-0 C20H21NO3 = 323.4 5mg QQ客服:2159513211
    马汉九里香碱; Mahanimbine CFN92197 21104-28-9 C23H25NO = 331.5 5mg QQ客服:1457312923
    异马汉九里香碱; Isomahanimbine CFN92198 26871-46-5 C23H25NO = 331.5 5mg QQ客服:2159513211





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