In vitro: |
Natural Product Communications, 2009, 4(8):1089-1092. | Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves.[Reference: WebLink] | In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro.
METHODS AND RESULTS:
All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, koenigicine and clausazoline-K, with IC50 values of 17.9 microM, 168.6 microM, 428.6 microM and <500 microM, respectively.
CONCLUSIONS:
This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants. |
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