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  • Glycoborinine

    Glycoborinine

    Glycoborinine
    产品编号 CFN89173
    CAS编号 233279-39-5
    分子式 = 分子量 C18H17NO2 = 279.33
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Glycosmis pentaphylla.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Glycoborinine CFN89173 233279-39-5 1mg QQ客服:1457312923
    Glycoborinine CFN89173 233279-39-5 5mg QQ客服:1457312923
    Glycoborinine CFN89173 233279-39-5 10mg QQ客服:1457312923
    Glycoborinine CFN89173 233279-39-5 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kitasato University (Japan)
  • China Medical University (Taiwan)
  • University of Indonesia (Indonesia)
  • Universidad Industrial de Santander (Colombia)
  • Copenhagen University (Denmark)
  • Universit?t Basel (Switzerland)
  • Pennsylvania State University (USA)
  • University of Perugia (Italy)
  • Almansora University (Egypt)
  • Universidad de La Salle (Mexico)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Hertfordshire (United Kingdom)
  • Subang Jaya Medical Centre (Malaysia)
  • John Innes Centre (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 198:91-97
  • Agriculture.2022, 12(3), 342.
  • Int J Mol Sci.2019, 20(8):E1855
  • J Anal Toxicol.2021, bkab015.
  • Sci Rep.2021, 11(1):11936.
  • Nutrients.2020, 12(12):3607.
  • Agriculture2022, 12(12), 2173.
  • Appl. Sci.2023, 13(17), 9653.
  • Fitoterapia.2021, 153:104995.
  • Foods.2022, 11(12):1708.
  • Antioxidants (Basel).2020, 9(4):326.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • J Biotechnol.2020, 318:10-19.
  • J Biomol Struct Dyn.2022, 1-21.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Front Pharmacol.2017, 8:673
  • Drug Chem Toxicol.2020, 1-12.
  • Food Chem. 2020, 320:126530
  • Nature Ecology & Evolution2020, doi: 10.1038
  • ...
  • 生物活性
    Description: Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-activated antimicrobial activity, it shows moderate inhibition on Nde I, Xba I, Nco I and Bcl I.
    Targets: ROS | Caspase | PARP | Nde I | Xba I | Nco I | Bcl‑2/Bax
    In vitro:
    Yao Xue Xue Bao. 2012 Dec;47(12):1646-52.
    Photo-activated DNA binding and antimicrobial activities of alkaloids from Glycosmis pentaphylla.[Pubmed: 23460971]
    In our screening for photosensitizers from natural resources, four
    METHODS AND RESULTS:
    alkaloids were isolated from Glycosmis pentaphylla by various chromatography techniques.Their structures were identified as Glycoborinine (1), glybomine B (2), carbalexin A (3) and N-p-coumaroyltyramine (4) by spectral analysis. Their photoactivated antimicrobial activities were evaluated by thin-layer chromatography (TLC) agar overlay assay against Staphylococcus aureus and Bacillus subtilis. It was found that compounds 1 and 4 showed photo-activated antimicrobial activities. Meantime, photo-activated DNA binding activities of these compounds were also assessed by using a specially prepared 1.8 kb DNA fragment and restriction enzymes.
    CONCLUSIONS:
    Under UVA irradiation, compound 1 showed moderate inhibition on Nde I, Xba I, Nco I and Bcl I which have either 5'-TpA or 5'-ApT and trace or no inhibition on other restriction enzymes. It showed a similar inhibition pattern with the reference 8-methoxypsoralen. However, compounds 2-4 showed no inhibition against any of the restriction enzymes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.58 mL 17.9 mL 35.7999 mL 71.5999 mL 89.4999 mL
    5 mM 0.716 mL 3.58 mL 7.16 mL 14.32 mL 17.9 mL
    10 mM 0.358 mL 1.79 mL 3.58 mL 7.16 mL 8.95 mL
    50 mM 0.0716 mL 0.358 mL 0.716 mL 1.432 mL 1.79 mL
    100 mM 0.0358 mL 0.179 mL 0.358 mL 0.716 mL 0.895 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Glycoborinine; Glycoborinine CFN89173 233279-39-5 C18H17NO2 = 279.33 5mg QQ客服:3257982914
    咔唑; Carbazole CFN96594 86-74-8 C12H9N = 167.21 5mg QQ客服:3257982914
    3-甲基-9H-咔唑-2-醇; 3-Methyl-9H-carbazol-2-ol CFN97777 24224-30-4 C13H11NO = 197.23 5mg QQ客服:1457312923
    3-甲基-6-羟基咔唑; Glycozolinine CFN98862 5257-08-9 C13H11NO = 197.2 5mg QQ客服:3257982914
    1-羟基-4-(3-甲基-2-丁烯基)-9H-咔唑-3-甲醛; Clausine D CFN97821 142846-95-5 C18H17NO2 = 279.34 5mg QQ客服:1413575084
    1-羟基-9H-咔唑-3-甲醛; Demethylmurrayanine CFN97840 123497-84-7 C13H9NO2 = 211.22 5mg QQ客服:1457312923
    九里香碱; Murrayanine CFN91484 723-97-7 C14H11NO2 = 225.2 5mg QQ客服:2159513211
    Clausine E; Clausine E CFN91823 182261-83-2 C14H11NO3 = 241.2 5mg QQ客服:215959384
    1,6-二羟基-9H-咔唑-3-甲醛; Clausine Z CFN97428 866111-14-0 C13H9NO3 = 227.2 5mg QQ客服:1457312923
    1-羟基-6-甲氧基-9H-咔唑-3-甲醛; Clausine I CFN97800 182261-94-5 C14H11NO3 = 241.24 5mg QQ客服:2159513211

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