马汉九里香碱
Mahanimbine
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 马汉九里香碱 |
CFN92197 |
21104-28-9 |
1mg |
QQ客服：2159513211 |
| 马汉九里香碱 |
CFN92197 |
21104-28-9 |
5mg |
QQ客服：2159513211 |
| 马汉九里香碱 |
CFN92197 |
21104-28-9 |
10mg |
QQ客服：2159513211 |
| 马汉九里香碱 |
CFN92197 |
21104-28-9 |
20mg |
QQ客服：2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Universidade Federal de Santa Catarina (Brazil)
Instituto de Investigaciones Agropecuarias (Chile)
MTT Agrifood Research Finland (Finland)
Chiang Mai University (Thailand)
Institute of Tropical Disease Universitas Airlangga (Indonesia)
Shanghai Institute of Biochemistry and Cell Biology (China)
Universiti Kebangsaan Malaysia (Malaysia)
Centrum Menselijke Erfelijkheid (Belgium)
National Cancer Center Research Institute (Japan)
Indian Institute of Science (India)
Aarhus University (Denmark)
Monash University Malaysia (Malaysia)
Uniwersytet Gdański (Poland)
The Australian National University (Australia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Mahanimbine inhibits AChE activity in a dose-dependent manner.
Mahanimbine can lower the absorption of dietary fat resulting in dietary fat excretion, it can prevent high-fat diet (HFD)-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine and mangiferin increases the glucose utilization in a dose-dependent manner, can prevent obesity and use in management of diabetes.
|
| Targets: |
AChR |
| In vitro: |
| Pharmacogn Mag. 2013 Jan;9(33):72-5. | | Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells.[Pubmed: 23661997] | To investigate the effects of mangiferin (xanthone glucoside) and mahanimbine (carbazole alkaloid) on glucose utilization in 3T3-L1 cells.
METHODS AND RESULTS:
Mangiferin was isolated from stem barks of Mangifera indica and mahanimbine was isolated from Murraya koenigii leaves. These isolated compounds were subjected to MTT assay and glucose utilization test with 3T3-L1 cells.
Treatment of the 3T3-L1 cells with mangiferin and mahanimbine increased the glucose utilization in a dose-dependent manner. At a concentration of 1 mM, mangniferin showed 2-fold increase in glucose utilization compared with untreated control. In case of mahanimbine, the observed effect at 1 mM was almost equivalent to positive control (insulin at 1 μM). Moreover, MTT assay showed that both of these compounds were less toxic at a concentration of 1 mM (nearly 75% cells are viable).
CONCLUSIONS:
The present results indicated that these natural products (mangiferin and mahanimbine) exhibited potential ethnomedical uses in management of diabetes. |
|
| In vivo: |
| Fitoterapia. 2010 Dec;81(8):1129-33. | | Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.[Pubmed: 20655993] |
METHODS AND RESULTS:
The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels.
CONCLUSIONS:
These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.0166 mL |
15.083 mL |
30.1659 mL |
60.3318 mL |
75.4148 mL |
| 5 mM |
0.6033 mL |
3.0166 mL |
6.0332 mL |
12.0664 mL |
15.083 mL |
| 10 mM |
0.3017 mL |
1.5083 mL |
3.0166 mL |
6.0332 mL |
7.5415 mL |
| 50 mM |
0.0603 mL |
0.3017 mL |
0.6033 mL |
1.2066 mL |
1.5083 mL |
| 100 mM |
0.0302 mL |
0.1508 mL |
0.3017 mL |
0.6033 mL |
0.7541 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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