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    • 马汉九里香碱

    Mahanimbine

    马汉九里香碱
    		产品编号 CFN92197
    CAS编号 21104-28-9
    分子式 = 分子量 C23H25NO = 331.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Murraya exotica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    马汉九里香碱 CFN92197 21104-28-9 1mg QQ客服：2159513211
    马汉九里香碱 CFN92197 21104-28-9 5mg QQ客服：2159513211
    马汉九里香碱 CFN92197 21104-28-9 10mg QQ客服：2159513211
    马汉九里香碱 CFN92197 21104-28-9 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Nat Commun.2019, 10(1):5169
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  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • J Appl Toxicol.2020, 40(7):965-978.
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  • Antioxidants (Basel).2021, 10(10):1638.
  • Mediators Inflamm.2016, 2016:7216912
  • Pharmaceuticals (Basel).2024, 17(3):341.
  • Functional Ecology2020, doi: 10.1111.
  • Molecules.2021, 26(2):313.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Univerzita Karlova2022, 173245.
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • Journal of Ginseng Research2021, 15 June.
  • Int J Mol Sci.2020, 21(24):9369.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Int J Mol Sci.2019, 20(9):E2244
  • Toxicol In Vitro.2023, 86:105521.
  • Sci Rep. 2017, 17332(7)
  • Antioxidants (Basel).2022, 11(8):1471.
  • FASEB J.2022, 36(7):e22387.
  • ...
    • 生物活性
    Description: Mahanimbine inhibits AChE activity in a dose-dependent manner. Mahanimbine can lower the absorption of dietary fat resulting in dietary fat excretion, it can prevent high-fat diet (HFD)-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine and mangiferin increases the glucose utilization in a dose-dependent manner, can prevent obesity and use in management of diabetes.
    Targets: AChR
    In vitro:
    Pharmacogn Mag. 2013 Jan;9(33):72-5.
    Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells.[Pubmed: 23661997]
    To investigate the effects of mangiferin (xanthone glucoside) and mahanimbine (carbazole alkaloid) on glucose utilization in 3T3-L1 cells.
    METHODS AND RESULTS:
    Mangiferin was isolated from stem barks of Mangifera indica and mahanimbine was isolated from Murraya koenigii leaves. These isolated compounds were subjected to MTT assay and glucose utilization test with 3T3-L1 cells. Treatment of the 3T3-L1 cells with mangiferin and mahanimbine increased the glucose utilization in a dose-dependent manner. At a concentration of 1 mM, mangniferin showed 2-fold increase in glucose utilization compared with untreated control. In case of mahanimbine, the observed effect at 1 mM was almost equivalent to positive control (insulin at 1 μM). Moreover, MTT assay showed that both of these compounds were less toxic at a concentration of 1 mM (nearly 75% cells are viable).
    CONCLUSIONS:
    The present results indicated that these natural products (mangiferin and mahanimbine) exhibited potential ethnomedical uses in management of diabetes.
    In vivo:
    Fitoterapia. 2010 Dec;81(8):1129-33.
    Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.[Pubmed: 20655993]

    METHODS AND RESULTS:
    The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels.
    CONCLUSIONS:
    These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0166 mL 15.083 mL 30.1659 mL 60.3318 mL 75.4148 mL
    5 mM 0.6033 mL 3.0166 mL 6.0332 mL 12.0664 mL 15.083 mL
    10 mM 0.3017 mL 1.5083 mL 3.0166 mL 6.0332 mL 7.5415 mL
    50 mM 0.0603 mL 0.3017 mL 0.6033 mL 1.2066 mL 1.5083 mL
    100 mM 0.0302 mL 0.1508 mL 0.3017 mL 0.6033 mL 0.7541 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-甲基-6-羟基咔唑; Glycozolinine CFN98862 5257-08-9 C13H11NO = 197.2 5mg QQ客服：1457312923
    1-羟基-4-(3-甲基-2-丁烯基)-9H-咔唑-3-甲醛; Clausine D CFN97821 142846-95-5 C18H17NO2 = 279.34 5mg QQ客服：1457312923
    1-羟基-9H-咔唑-3-甲醛; Demethylmurrayanine CFN97840 123497-84-7 C13H9NO2 = 211.22 5mg QQ客服：215959384
    九里香碱; Murrayanine CFN91484 723-97-7 C14H11NO2 = 225.2 5mg QQ客服：1413575084
    Clausine E; Clausine E CFN91823 182261-83-2 C14H11NO3 = 241.2 5mg QQ客服：1457312923
    1,6-二羟基-9H-咔唑-3-甲醛; Clausine Z CFN97428 866111-14-0 C13H9NO3 = 227.2 5mg QQ客服：2159513211
    1-羟基-6-甲氧基-9H-咔唑-3-甲醛; Clausine I CFN97800 182261-94-5 C14H11NO3 = 241.24 5mg QQ客服：3257982914
    2,8-二羟基-9H-咔唑-3-甲醛; Clauszoline M CFN97796 187110-72-1 C13H9NO3 = 227.22 5mg QQ客服：1413575084
    柯里九里香碱; Curryangine CFN92926 25488-37-3 C23H25NO = 331.45 5mg QQ客服：1413575084
    Murrayamine E; Murrayamine E CFN92927 172617-68-4 C23H25NO2 = 347.45 5mg QQ客服：1457312923

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