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  • 石吊兰甲素

    Lysionotin

    石吊兰甲素
    产品编号 CFN99787
    CAS编号 152743-19-6
    分子式 = 分子量 C18H16O7 = 344.32
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lysionotus pauciflorus Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    石吊兰甲素 CFN99787 152743-19-6 10mg QQ客服:2056216494
    石吊兰甲素 CFN99787 152743-19-6 20mg QQ客服:2056216494
    石吊兰甲素 CFN99787 152743-19-6 50mg QQ客服:2056216494
    石吊兰甲素 CFN99787 152743-19-6 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyung Hee University (Korea)
  • MTT Agrifood Research Finland (Finland)
  • Universitas islam negeri Jakarta (Indonesia)
  • Uniwersytet Gdański (Poland)
  • Ateneo de Manila University (Philippines)
  • Universidade do Porto (Portugal)
  • University of Medicine and Pharmacy (Romania)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Pennsylvania State University (USA)
  • Universidad de La Salle (Mexico)
  • National Research Council of Canada (Canada)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Siksha O Anusandhan University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Biol Macromol.2018, 112:1093-1103
  • Fitoterapia.2018, 124:92-102
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Drug Des Devel Ther.2020, 14:61-71
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Plants (Basel).2021, 10(5):951.
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • LWT2021, 138:110397.
  • Int J Mol Sci.2023, 24(8):7442.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Phytochemistry.2017, 141:162-170
  • Front Microbiol.2021, 12:736780.
  • Food Chemistry2023, 137837.
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Microorganisms.2021, 9(12):2514.
  • Plos One.2019, 15(2):e0220084
  • J Pharm Biomed Anal2016, 118:183-194
  • Int J Mol Sci.2023, 24(5):4505.
  • Planta Med.2019, 85(9-10):766-773
  • Food Analytical Methods2017, 10:3225-3234
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Phytomedicine.2018, 41:62-66
  • ...
  • 生物活性
    Description: Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. It is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
    In vitro:
    Appl Microbiol Biotechnol. 2017 Sep;101(17):6697-6703.
    Lysionotin attenuates Staphylococcus aureus pathogenicity by inhibiting α-toxin expression.[Pubmed: 28710557 ]
    α-Toxin, one of the best known pore-forming proteins produced by Staphylococcus aureus (S. aureus), is a critical virulence factor in multiple infections. The necessity of α-toxin for S. aureus pathogenicity suggests that this toxin is an important target for the development of a potential treatment strategy.
    METHODS AND RESULTS:
    In this study, we showed that lysionotin, a natural compound, can inhibit the hemolytic activity of culture supernatants by S. aureus by reducing α-toxin expression. Using real-time PCR analysis, we showed that transcription of hla (the gene encoding α-toxin) and agr (the locus regulating hla) was significantly inhibited by lysionotin. Lactate dehydrogenase and live/dead assays indicated that lysionotin effectively protected human alveolar epithelial cells against S. aureus, and in vivo studies also demonstrated that lysionotin can protect mice from pneumonia caused by S. aureus. These findings suggest that lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo.
    CONCLUSIONS:
    This study supports a potential strategy for the treatment of S. aureus infection by inhibiting the expression of virulence factors and indicates that lysionotin may be a potential treatment for S. aureus pneumonia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9043 mL 14.5214 mL 29.0428 mL 58.0855 mL 72.6069 mL
    5 mM 0.5809 mL 2.9043 mL 5.8086 mL 11.6171 mL 14.5214 mL
    10 mM 0.2904 mL 1.4521 mL 2.9043 mL 5.8086 mL 7.2607 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1617 mL 1.4521 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:215959384
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:3257982914
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:1413575084
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 10mg QQ客服:1413575084
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:2159513211
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:2159513211
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:2056216494
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 20mg QQ客服:2159513211
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:1457312923
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:2056216494

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