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  • 蓟黄素


    产品编号 CFN97126
    CAS编号 6601-62-3
    分子式 = 分子量 C17H14O6 = 314.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Microtea debilis.
    产品名称 产品编号 CAS编号 包装 QQ客服
    蓟黄素 CFN97126 6601-62-3 1mg QQ客服:1413575084
    蓟黄素 CFN97126 6601-62-3 5mg QQ客服:1413575084
    蓟黄素 CFN97126 6601-62-3 10mg QQ客服:1413575084
    蓟黄素 CFN97126 6601-62-3 20mg QQ客服:1413575084
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universidad Veracuzana (Mexico)
  • Monash University (Australia)
  • The Australian National University (Australia)
  • Pennsylvania State University (USA)
  • Regional Crop Research Institute (Korea)
  • Chungnam National University (Korea)
  • University of Madras (India)
  • Monash University Sunway Campus (Malaysia)
  • Celltrion Chemical Research Institute (Korea)
  • John Innes Centre (United Kingdom)
  • Kitasato University (Japan)
  • Korea Institute of Oriental Medicine (Korea)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Universiti Sains Malaysia (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Toxicol In Vitro.2018, 52:94-105
  • J Neuroinflammation.2020, 17(1):75.
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Indian J. of Experimental Bio.2020, 9(58).
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  • iScience.2020, 23(2):100849.
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  • ...
  • 生物活性
    Description: Cirsimaritin has antibacterial, anti- inflammation, anti-tumor, antioxidant, renal protection and so on, it has potential use in patients with congestive heart failure, it can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner;support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments.
    Targets: Tyrosinase | cAMP | PKA | Akt | NADPH-oxidase | Calcium Channel | TNF-α | Antifection
    In vitro:
    Int J Mol Sci. 2015 Apr 20;16(4):8772-88.
    Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.[Pubmed: 25903150]
    The melanin-inducing properties of Cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which is isolated from the branches of Lithocarpus dealbatus.
    Tyrosinase activity and melanin content in murine B16F10 melanoma cells were increased by Cirsimaritin in a dose-dependent manner. Western blot analysis revealed that tyrosinase, tyrosinase-related protein (TRP) 1, TRP2 protein levels were enhanced after treatment with Cirsimaritin for 48 h. Cirsimaritin also upregulated the expression of microphthalmia-associated transcription factor (MITF) after 24 h of treatment. Furthermore, Cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min. The Cirsimaritin-mediated increase of tyrosinase activity was significantly attenuated by H89, a cAMP-dependent protein kinase A inhibitor. These findings indicate that Cirsimaritin stimulates melanogenesis in B16F10 cells by activation of CREB as well as upregulation of MITF and tyrosinase expression, which was activated by cAMP signaling. Finally, the melanogenic effect of Cirsimaritin was confirmed in human epidermal melanocytes.
    These results support the putative application of Cirsimaritin in ultraviolet photoprotection and hair coloration treatments.
    Cancer Lett. 2010 Sep 28;295(2):252-9.
    Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells.[Pubmed: 20359814]
    In this study, the anticancer effect of Cirsimaritin, a natural flavonoid, against human gallbladder carcinoma cell line GBC-SD and the underlying mechanisms were investigated.
    Cirsimaritin inhibited the growth of tumor cells and induced mitochondrial apoptosis in GBC-SD cells. In addition, Cirsimaritin triggered endoplasmic reticulum (ER) stress and down-regulated the phosphorylation of Akt, while knock-down of CHOP dramatically abrogated the inactivation of Akt and reversed the pro-apoptotic effect of Cirsimaritin. Furthermore, Cirsimaritin provoked the generation of reactive oxygen species in GBC-SD cells, while the antioxidant N-acetyl cysteine almost completely blocked the activation of ER stress and apoptosis, suggesting Cirsimaritin-induced reactive oxygen species is an early event that triggers ER stress mitochondrial apoptotic pathways in GBC-SD cells.
    In vivo:
    Int .J. Clin. Exp. Pathol .,2016;9(2):509-20.
    Cirsimaritin ameliorates cardiac remodeling and dysfunction through promoting myocardial autophagy in rats with heart failure.[Reference: WebLink]
    Cirsimaritin, a natural flavone, has been reported to exert various activities including antibacterial, anti-inflammation, anti-tumor, antioxidant, renal protection and so on. However, despite these pharmacological studies, whether Cirsimaritin alleviates heart failure is still unknown.
    Administration of isoproterenol led to a serious heart failure, as evidenced by the up-regulation of heart rate, weight index and end diastolic pressure of left ventricular, while by the down-regulation of left ventricular systolic pressure, maximal rate of pressure rise or decline of left ventricular. Pretreatment of Cirsimaritin significantly ameliorated these cardiac parameters in a dose-dependent manner. In addition, Cirsimaritin remarkably inhibited serum levels of Ang II, NE, TNF-α and BNP in rats with heart failure and attenuated the cardiac histological changes. Moreover, matrix metalloproteinase-2&9 activities were also suppressed by Cirsimaritin. Furthermore, myocardial autophagy was significantly promoted by Cirsimaritin in vivo and in vitro through inhibiting AKT1-RPS6KB1 signaling.
    These findings reveal that Cirsimaritin mitigates cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities, suggesting its potential use in patients with congestive heart failure.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:2159513211
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:215959384
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:1148253675
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 10mg QQ客服:1148253675
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:3257982914
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:215959384
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:1148253675
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 20mg QQ客服:1148253675
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:215959384
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1148253675





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