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  • 芫花素

    Genkwanin

    芫花素
    产品编号 CFN98670
    CAS编号 437-64-9
    分子式 = 分子量 C16H12O5 = 284.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lobelia chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芫花素 CFN98670 437-64-9 10mg QQ客服:2159513211
    芫花素 CFN98670 437-64-9 20mg QQ客服:2159513211
    芫花素 CFN98670 437-64-9 50mg QQ客服:2159513211
    芫花素 CFN98670 437-64-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Osmania University (India)
  • University of Maryland School of Medicine (USA)
  • Srinakharinwirot University (Thailand)
  • Universita' Degli Studi Di Cagliari (Italy)
  • University of Helsinki (Finland)
  • University of Auckland (New Zealand)
  • Massachusetts General Hospital (USA)
  • Monash University (Australia)
  • Anna University (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • The Institute of Cancer Research (United Kingdom)
  • University of Bordeaux (France)
  • University of the Basque Country (Spain)
  • University of British Columbia (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Res.2022, 182:106346.
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Pharmaceutics.2021, 13(7):1028.
  • Phytomedicine.2022, 100:154036.
  • Ind Crops Prod.2014, 62:173-178
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Cell Rep.2022, 39(1):110643.
  • Genes Genomics.2020, 10.1007
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • FEBS Lett.2015, 589(1):182-7
  • Appl. Sci. 2021, 11(22),10569
  • Toxicol In Vitro.2022, 81:105346.
  • Plant J.2021, 107(6):1711-1723.
  • Nutrients.2021, 13(1):254.
  • Sci Rep.2015, 5:13194
  • PLoS One.2021, 16(6):e0248479.
  • Int J Mol Sci.2018, 19(9):E2528
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Saf Health Work.2019, 10(2):196-204
  • Appl. Sci. 2021, 11(1),14.
  • Front. Physiol.2022, 790345.
  • ...
  • 生物活性
    Description: Genkwanin has antitumor, and anti-inflammatory activities, it enhances host immunity, decreases the inflammatory cytokine levels, and regulates the miR-101/MKP-1/MAPK pathway.Genkwanin may have anti-skin ageing activity, it can up-regulate the transcriptional activation of human type vii collagen gene promoter, stimulating the formation of anchoring fibrils at the basement membrane zone in skin contributed to preventing skin ageing; it also induces a decrease of melanin synthesis by inhibiting tyrosinase activity, it could as skin whitening agent in cosmetic preparations.
    Targets: NOS | TNF-α | p38MAPK | JNK | AP-1 | Akt | IL Receptor
    In vitro:
    PLoS One. 2014 May 6;9(5):e96741.
    Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages.[Pubmed: 24800851]
    Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-inflammatory activities. Although its anti-inflammatory activity in vivo has been reported, the potential molecular mechanisms remain obscure.
    METHODS AND RESULTS:
    In this study, by pharmacological and genetic approaches, we explore the anti-inflammatory effects of genkwanin in LPS-activated RAW264.7 macrophages. Genkwanin potently decreases the proinflammatory mediators, such as iNOS, TNF-α, IL-1β and IL-6, at the transcriptional and translational levels without cytotoxicity, indicating the excellent anti-inflammatory potency of genkwanin in vitro. Mechanism study shows that genkwanin significantly suppresses the p38- and JNK-mediated AP-1 signaling pathway and increases the mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) expression at the posttranscriptional level. We also confirmed that microRNA-101 (miR-101) is a negative regulator of MKP-1 expression. Moreover, regardless of miR-101-deficient cells or miR-101-abundant cells, the suppression effects of genkwanin on supernatant proinflammatory mediators' levels are far less than that in respective negative control cells, suggesting that genkwanin exerts anti-inflammatory effect mainly through reducing miR-101 production. However, genkwanin can't affect the level of phospho-Akt (p-Akt), indicating that the phosphorylation of Akt may be not responsible for the effect of genkwanin on miR-101 production.
    CONCLUSIONS:
    We conclude that genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-101/MKP-1/MAPK pathway.
    Int. J.Cosmetic Sci., 2007, 29(4):332- 3.
    Genkwanin up-regulates the transcriptional activation of human type vii collagen gene promoter.[Reference: WebLink]

    METHODS AND RESULTS:
    In a recent study, stimulating the formation of anchoring fibrils at the basement membrane zone in skin contributed to preventing skin ageing, such as wrinkle formation. Expression of the type VII collagen gene induces the formation of anchoring fibrils composed mainly of collagen type VII. We therefore transiently transfected a keratinocyte cell line with the plasmids containing type VII collagen gene promoter located upstream of the luciferase gene.
    CONCLUSIONS:
    We investigated the promoter activity under the presence of flavonoids and we found that Genkwanin up-regulates the transcriptional activation of human type VII collagen gene promoter.
    In vivo:
    Int Immunopharmacol. 2015 Dec;29(2):701-707.
    Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice.[Pubmed: 26388189 ]
    Colorectal cancer is the third most common malignant tumor with high morbidity and mortality.
    METHODS AND RESULTS:
    To evaluate the antitumor effect of genkwanin on colorectal cancer enhanced by western high-fat diet, we investigated the activity of genkwanin on HT-29 and SW-480 human colorectal cancer lines in vitro and on the APC(Min/+) mice in vivo. In a cell culture system, six different inflammatory cytokines obviously stimulated two cancer cells growth in a concentration-dependent manner, while genkwanin significantly inhibited HT-29 and SW-480 human colorectal cancer cells proliferation and inflammatory cytokine IL-8 secretion. In the APC(Min/+) mice, the body weights, spleen and thymus indexes and immunity cytokine secretions were significantly improved after oral administration 12.5 and 25mg/kg/day of genkwanin. Besides, the tumor multiplicity changes and inflammatory cytokine levels were markedly reduced in two genkwanin-treated groups. The dysplastic adenomatous changes were also obviously ameliorated in gut histopathology.
    CONCLUSIONS:
    Taken together, our results indicated that genkwanin had a better antitumor activity partly via enhancing host immunity and decreasing the inflammatory cytokine levels. Genkwanin may be an effective chemotherapeutic agent for the treatment of colorectal cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
    5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
    10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
    50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
    100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:2932563308
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:2159513211
    5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin CFN98819 5128-44-9 C17H14O5 = 298.3 5mg QQ客服:1148253675
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 20mg QQ客服:215959384
    5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein CFN96380 10176-71-3 C17H14O6 = 314.3 5mg QQ客服:215959384
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:2159513211
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:1413575084
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:215959384
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 10mg QQ客服:215959384
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:215959384

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