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  • 野黄芩素


    产品编号 CFN98557
    CAS编号 529-53-3
    分子式 = 分子量 C15H10O6 = 286.24
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis Georgi
    产品名称 产品编号 CAS编号 包装 QQ客服
    野黄芩素 CFN98557 529-53-3 10mg QQ客服:1148253675
    野黄芩素 CFN98557 529-53-3 20mg QQ客服:1148253675
    野黄芩素 CFN98557 529-53-3 50mg QQ客服:1148253675
    野黄芩素 CFN98557 529-53-3 100mg QQ客服:1148253675
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Hull (United Kingdom)
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  • Mendel University in Brno (Czech Republic)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Bonn (Germany)
  • University of Otago (New Zealand)
  • Georgia Institute of Technology (USA)
  • University of Melbourne (Australia)
  • Celltrion Chemical Research Institute (Korea)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Monash University Malaysia (Malaysia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Toulouse (France)
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  • ...
  • 生物活性
    Description: Scutellarein has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities, it can improve neuronal injury, has better protective effect in rat cerebral ischemia. Scutellarein may serve as a SARS-CoV chemical inhibitor, it also exerts strong inhibition towards the tested UDP-glucuronosyltransferase isoforms.
    Targets: Calcium Channel | Sodium Channel | ATPase | Potassium Channel | MMP(e.g.TIMP) | ERK | NF-kB | EGFR | COX | Antifection
    In vitro:
    Chin J Physiol. 2014 Aug 31;57(4):182-7.
    Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway.[Pubmed: 25246059]
    High expression levels of cyclooxygenase-2 (COX-2) contribute a strong proliferative ability to human lung cancer cells, and this function is link to the epidermal growth factor receptor (EGFR) pathway, which was mediated by extracellular-signal-regulated kinase (ERK) and nuclear factor kappa B (NFκB).
    In this study, Scutellarein, a flavonoid compound, was screened for proliferation inhibition at different concentrations (0, 5, 25 and 50 μM) at 24 h or 48 h in human lung cancer cell line A549. Results showed that A549 cell proliferation was inhibited by 50 μM Scutellarein treatment in 24 h and 48 h of treatment. The expression levels of phosphorylated EGFR, phosphorylated ERK, phosphorylated NFκB and COX-2 were reduced in a dose-dependent manner after 24 h Scutellarein treatments at different concentrations. Further, ERK inhibitor U0126 and NFκB inhibitor MG132 also inhibited A549 cell proliferation similar to 50 κM Scutellarein treatment from 24 h to 48 h.
    The experimental results showed that Scutellarein could inhibit proliferation of the human lung cancer cell line A549 through ERK and NFκB mediated by the EGFR pathway.
    In vivo:
    Pharmacol Biochem Behav. 2014 Mar;118:51-9.
    Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats.[Pubmed: 24423938]
    Scutellarin had protective effects against neuronal injury, however, there are few studies on the protective effect of scutellarein, which is the main metabolite of scutellarin in vivo.
    This study investigated whether the neural injury by ischemia/reperfusion would be influenced by different doses of scutellarin and scutellarein. Male Wistar rats were orally administered with scutellarin and scutellarein at the doses of 0.09, 0.17, 0.35, 0.70, 1.40 mmol/kg, respectively; then after six consecutive days, they were subjected to global ischemia by occlusion of the bilateral common carotid arteries (BCCAO). After reperfusion for about 21 h, neurological and histological examinations were performed. The present results showed that scutellarein attenuated neuronal cell damage, reduced cerebral water content, regulated the expression of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), γ-aminobutyric acid (GABA) and taurine (Tau), and improved the Ca(2+)-ATPase and Na(+),K(+)-ATPase activity. Meanwhile, significant difference was found among various doses of scutellarin and scutellarein.
    Our studies indicated that scutellarin and scutellarein could improve neuronal injury, and scutellarein had better protective effect than scutellarin in rat cerebral ischemia.
    Int J Mol Med. 2015 Jan;35(1):31-8.
    Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.[Pubmed: 25394920]
    Fibrosarcoma is an aggressive and highly metastatic cancer of the connective tissue, for which effective therapeutic methods are limited. Recently, there has been a renewed interest in small molecular compounds from natural products in the treatment of cancer.
    In the present study, we investigated the compound, Scutellarein, extracted from the perennial herb Scutellaria lateriflora, and it was found to possess anticancer potential. Cell proliferation assay and cell cycle analysis revealed that the proliferation rate of HT1080 human fibrosarcoma cells was significantly suppressed by treatment with Scutellarein through the induction of apoptosis. Moreover, an in vivo experiment using Balb/c nude mice revealed that the volume and weight of the tumors were markedly reduced following treatment with Scutellarein. We also analyzed the effects of Scutellarein on the markers of metastasis, using the HT1080 cells. The results indicated that Scutellarein potently inhibited cell migration, invasion and the expression and activity of matrix metalloproteinase (MMP)-2, -9 and -14. Furthermore, MMP activation and cell survival were suppressed due to the Scutellarein-mediated downregulation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation.
    In conclusion, our data suggest that Scutellarein has the ability to attenuate the development of fibrosarcoma and inhibit cancer cell metastasis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4936 mL 17.4679 mL 34.9357 mL 69.8714 mL 87.3393 mL
    5 mM 0.6987 mL 3.4936 mL 6.9871 mL 13.9743 mL 17.4679 mL
    10 mM 0.3494 mL 1.7468 mL 3.4936 mL 6.9871 mL 8.7339 mL
    50 mM 0.0699 mL 0.3494 mL 0.6987 mL 1.3974 mL 1.7468 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6987 mL 0.8734 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:1148253675
    5-羟基-4’,7-二甲氧基黄酮; 7,4'-Di-O-methylapigenin CFN98819 5128-44-9 C17H14O5 = 298.3 5mg QQ客服:1413575084
    三甲基芹菜素; Trimethylapigenin CFN91890 5631-70-9 C18H16O5 = 312.32 20mg QQ客服:2159513211
    5,6-二羟基-7,4'-二甲氧基黄酮; Ladanein CFN96380 10176-71-3 C17H14O6 = 314.3 5mg QQ客服:1148253675
    柳穿鱼黄素; Pectolinarigenin CFN99010 520-12-7 C17H14O6 = 314.3 20mg QQ客服:1413575084
    三裂鼠尾草素; Salvigenin CFN99883 19103-54-9 C18H16O6 = 328.3 10mg QQ客服:3257982914
    4',5,6,7-四甲氧基黄酮; 4',5,6,7-Tetramethoxyflavone CFN91034 1168-42-9 C19H18O6 = 342.4 5mg QQ客服:215959384
    4,5,7,8,-四甲氧基黄酮; 6-Demethoxytangeretin CFN93255 6601-66-7 C19H18O6 = 342.4 10mg QQ客服:3257982914
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:215959384
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:2159513211





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