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  • 异甘草苷

    Isoliquiritin

    异甘草苷
    产品编号 CFN99155
    CAS编号 5041-81-6
    分子式 = 分子量 C21H22O9 = 418.39
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Glycyrrhiza uralensis Fisch.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异甘草苷 CFN99155 5041-81-6 10mg QQ客服:1413575084
    异甘草苷 CFN99155 5041-81-6 20mg QQ客服:1413575084
    异甘草苷 CFN99155 5041-81-6 50mg QQ客服:1413575084
    异甘草苷 CFN99155 5041-81-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Texas A&M University (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Kamphaengphet Rajabhat University (Thailand)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Illinois at Chicago (USA)
  • University of Vienna (Austria)
  • University of Wollongong (Australia)
  • VIT University (India)
  • Auburn University (USA)
  • University of Hertfordshire (United Kingdom)
  • CSIRO - Agriculture Flagship (Australia)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of the Basque Country (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Nutr.2021, 8: 687851.
  • J Nat Med.2020, 74(3):550-560.
  • Molecules.2021, 26(6):1635.
  • Molecules.2019, 24(1):E159
  • J Anal Methods Chem.2022, 2022:2229500.
  • Pharm Biol.2017, 55(1):360-366
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Int J Mol Sci.2022, 23(24):16000.
  • Pharmaceutics.2020, 12(9):882.
  • Agronomy2022, 12(10), 2426.
  • Phytomedicine.2019, 55:229-237
  • Nutrients.2019, 12(1)
  • J Chromatogr Sci.2015, 53(5):824-9
  • Biomolecules.2022, 12(12):1754.
  • Biomolecules2021, 11(10),1513.
  • Molecules.2020, 25(9):2111.
  • Elife.2021, 10:e68058.
  • Aquaculture2017, 481:94-102
  • Int J Med Sci.2020, 17(5):626-631
  • J of Apicultural Research2020, 10.1080
  • bioRxiv - Biochemistry2023, 548213.
  • Nutr Metab (Lond).2019, 16:31
  • ...
  • 生物活性
    Description: Isoliquiritin has significant antidepressant-like, antifungal and anti-cancer activities. It induces apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosstalk between Akt activities.
    Targets: Mdm2 | GSK-3 | Akt | Raf | PTEN | Caspase | PARP | Bcl-2/Bax | p53 | p21 | 5-HT Receptor | Antifection
    In vitro:
    Oncol Rep. 2014 Jan;31(1):298-304.
    Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells.[Pubmed: 24247527]
    Liquiritin, isoliquiritin and isoliquirigenin are the active polyphenols present in Glycyrrhiza uralensis which has been used for the treatment of cancer and its complications.
    METHODS AND RESULTS:
    The present study was conducted to evaluate the cytotoxicity and antitumor activity of liquiritin, isoliquiritin and isoliquirigenin on human non-small lung cancer cells including apoptosis-induction, inhibition of apoptotic pathways and to explore the underlying mechanism. Lactate dehydrogenase assays, FITC Annexin V staining assay were performed to evaluate cellular cytotoxicity and apoptosis activity. The results showed that pretreatment with these polyphenols induced apoptosis in A549 cells. Liquiritin, isoliquiritin and isoliquirigenin significantly increased cytotoxicity of, and upregulated p53 and p21 and downregulated the apoptotic pathways. Furthermore, it inhibited cell cycle at the G2/M phase. Western blot analysis showed it significantly decreased the protein expression of PCNA, MDM2, p-GSK-3β, p-Akt, p-c-Raf, p-PTEN, caspase-3, pro-caspase-8, pro-caspase-9 and PARP, Bcl-2 in a concentration-dependent manner while the protein expression of p53, p21 and Bax was increased. In addition, Akt pathway was downregulated.
    CONCLUSIONS:
    These findings suggest that liquiritin, isoliquiritin and isoliquirigenin inhibited the p53-dependent pathway and showed crosstalk between Akt activities. These active polyphenols can be an alternative agent for the treatment of lung cancer.
    Molecules. 2016 Feb 19;21(2):237.
    Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism.[Pubmed: 26907232 ]

    METHODS AND RESULTS:
    This study investigated the antifungal activity and potential antifungal mechanism(s) of isoliquiritin against P. litchi Chen, one of the main litchi pathogens. The antifungal activity of isoliquiritin against P. litchi Chen had been proven in a dose-dependent manner through in vitro (mycelial growth and sporangia germination) and in vivo (detached leaf) tests. Results revealed that isoliquiritin exhibited significant antifungal activity against the tested pathogens, especially, P. litchi Chen, with a minimum inhibitory concentration of 27.33 mg/L. The morphology of P. litchi Chen was apparently changed by isoliquiritin through cytoplasm leakage and distortion of mycelia. The cell membrane permeability of the P. litchi Chen increased with the increasing concentration of isoliquiritin, as evidenced by a rise in relative electric conductivity and a decrease in reducing sugar contents. These results indicated that the antifungal effects of isoliquiritin could be explained by a membrane lesion mechanism causing damage to the cell membrane integrity leading to the death of mycelial cells.
    CONCLUSIONS:
    Taken together, isoliquiritin may be used as a natural alternative to commercial fungicides or a lead compound to develop new fungicides for the control of litchi downy blight.
    In vivo:
    Biol Pharm Bull. 1995 Oct;18(10):1382-6.
    Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.[Pubmed: 8593441]
    A water extract of licorice root inhibits granuloma angiogenesis in adjuvant-induced chronic inflammation (Phytother. Res., 5, 195. 1991).
    METHODS AND RESULTS:
    The present study has investigated the effects of licorice-derived compounds on granuloma angiogenesis. Isoliquiritin (0.31-3.1 mg/kg), a licorice-derived flavonoid, inhibited the carmine content of granuloma tissue 50-fold greater than licorice extract. Glyeyrrhizin (20-80 mg/kg), a licorice-derived saponin, inhibited carmine content with a weak potency. The licorice extract (0.01-1 mg/ml) also inhibited tube formation from vascular endothelial cells in a concentration-dependent manner. From the chemical structure-activities of used licorice-derived flavonoids (0.1-100 microM), their potencies for anti-tube formation were in the order isoliquiritigenin > isoliquiritin > liquiritigenin >> isoliquiritin-apioside. Glycyrrhizin (0.1-100 microM) and glycyrrhetinic acid (0.1-10 microM) increased tube formation. A glycyrrhizin (82 micrograms/ml)-induced increase in tube formation was inhibited by isoliquiritin. The combined effect of a mixture of 82 micrograms/ml glycyrrhizin and 4.2 micrograms/ml isoliquiritin, a similar concentration ratio to their yield ratio in the licorice extract, corresponded to the effect of 100 micrograms/ml extract.
    CONCLUSIONS:
    In conclusion, the anti-angiogenic effect of licorice extract depended on the anti-tube formation effect of isoliquiritin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3901 mL 11.9506 mL 23.9011 mL 47.8023 mL 59.7529 mL
    5 mM 0.478 mL 2.3901 mL 4.7802 mL 9.5605 mL 11.9506 mL
    10 mM 0.239 mL 1.1951 mL 2.3901 mL 4.7802 mL 5.9753 mL
    50 mM 0.0478 mL 0.239 mL 0.478 mL 0.956 mL 1.1951 mL
    100 mM 0.0239 mL 0.1195 mL 0.239 mL 0.478 mL 0.5975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢马里苷; Dihydromarein CFN90853 N/A C21H24O11 = 452.4 5mg QQ客服:1413575084
    马里苷; Marein CFN90851 535-96-6 C21H22O11 = 450.4 10mg QQ客服:215959384
    新异甘草苷; Neoisoliquiritin CFN90823 59122-93-9 C21H22O9 = 418.4 10mg QQ客服:2159513211
    异甘草苷; Isoliquiritin CFN99155 5041-81-6 C21H22O9 = 418.39 20mg QQ客服:2056216494
    芹糖异甘草苷; Isoliquiritin apioside CFN90800 120926-46-7 C26H30O13 = 550.5 20mg QQ客服:1457312923
    弗罗利辛二水合物; Phlorizin dihydrate CFN90442 7061-54-3 C21H24O10.2H2O = 472.44 20mg QQ客服:2159513211
    Asebotin; Asebotin CFN96929 11075-15-3 C22H26O10 = 450.44 5mg QQ客服:2159513211
    三叶甙; Trilobatin CFN98658 4192-90-9 C21H24O10 = 436.4 20mg QQ客服:1457312923
    三叶甙2''-乙酸酯; Trilobatin 2''-acetate CFN97111 647853-82-5 C23H26O11 = 478.5 5mg QQ客服:1413575084
    Nothofagin; Nothofagin CFN92888 11023-94-2 C21H24O10 = 436.4 5mg QQ客服:1457312923

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