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  • 橙皮苷甲基查尔酮

    Hesperidin methylchalcone

    橙皮苷甲基查尔酮
    产品编号 CFN80405
    CAS编号 24292-52-2
    分子式 = 分子量 C29H36O15 = 624.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Myrtus communis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    橙皮苷甲基查尔酮 CFN80405 24292-52-2 10mg QQ客服:3257982914
    橙皮苷甲基查尔酮 CFN80405 24292-52-2 20mg QQ客服:3257982914
    橙皮苷甲基查尔酮 CFN80405 24292-52-2 50mg QQ客服:3257982914
    橙皮苷甲基查尔酮 CFN80405 24292-52-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bonn (Germany)
  • Universiti Sains Malaysia (Malaysia)
  • Mahatma Gandhi University (India)
  • Monash University Sunway Campus (Malaysia)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Washington State University (USA)
  • Osmania University (India)
  • Univerzita Karlova v Praze (Czech Republic)
  • Kazusa DNA Research Institute (Japan)
  • Universidad de Buenos Aires (Argentina)
  • Monash University Malaysia (Malaysia)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Beira Interior (Portugal)
  • University of Mysore (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2016, 27(5):296-303
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Int J Mol Sci.2021, 22(19):10220.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Anticancer Res.2014, 34(7):3505-9
  • University of Stuttgart2021, 11682.
  • Food Chem.2019, 275:746-753
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • Front Pharmacol.2017, 8:205
  • Food Chem Toxicol.2023, 176:113785.
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • J Exp Bot.2016, 67(12):3777-88
  • J Ethnopharmacol.2016, 192:370-381
  • Molecules.2016, 21(10)
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Biomedicines.2022, 10(2):463.
  • Food Chem.2019, 278:683-691
  • J Pharm Biomed Anal.2021, 196:113931.
  • Pharm Biol.2021, 59(1):134-145.
  • Int Immunopharmacol.2023, 125:111175.
  • J Cancer.2019, 10(23):5843-5851
  • ...
  • 生物活性
    Description: Hesperidin methylchalcone has anti-inflammatory effects, it can suppresse experimental gout arthritis in mice by inhibiting NF-κB activation. Hesperidin methylchalcone can regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Hesperidin methylchalcone has a protective effect against leakage of FITC-dextran in the cheek pouch after administration of various permeability-increasing substances. It is a promising new therapeutic approach to protecting the skin from the deleterious effects of UVB irradiation.
    Targets: TNF-α | IL Receptor | TGF-β/Smad | NF-kB | Caspase | Nrf2 | HO-1 | NADPH-oxidase | TRPV | Akt | PKC
    In vivo:
    Photochem Photobiol Sci. 2016 Apr;15(4):554-63.
    Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation.[Pubmed: 27021784]
    Skin exposure to ultraviolet B (UVB) irradiation has increased significantly in recent years due to ozone depletion, and it represents the main cause of many skin diseases. Hesperidin methylchalcone (HMC) is a compound used to treat vascular diseases that has demonstrated anti-inflammatory activities in pre-clinical studies.
    METHODS AND RESULTS:
    Herein, we tested the antioxidant activity of HMC in cell free systems and the in vivo effects of a stable topical formulation containing HMC in a mouse model of skin oxidative stress and inflammation induced by UVB irradiation. HMC presented ferric reducing power, neutralized 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl free radicals, and inhibited lipid peroxidation. In hairless mice, a topical formulation containing HMC inhibited UVB irradiation-induced skin edema, depletion of antioxidant capacity (ferric and ABTS reducing abilities and catalase activity), lipid peroxidation, superoxide anion production and mRNA expression of gp91phox (nicotinamide adenine dinucleotide phosphate [NADPH] oxidase 2 sub-unity). In addition, HMC inhibited UVB irradiation-induced depletion of reduced glutathione levels by maintaining glutathione peroxidase-1 and glutathione reductase mRNA expression, prevented down-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression and increased heme oxygenase-1 mRNA expression. Finally, we demonstrated that topical application of the formulation containing HMC inhibited cytokine (TNF-α, IL-1β, IL-6, and IL-10) production induced by UVB irradiation.
    CONCLUSIONS:
    Therefore, this topical formulation containing HMC is a promising new therapeutic approach to protecting the skin from the deleterious effects of UVB irradiation.
    Chem Biol Interact. 2015 Feb 25;228:88-99.
    Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: role of TRPV1, oxidative stress, cytokines and NF-κB.[Pubmed: 25617481 ]
    Cytokines and reactive oxygen species are inflammatory mediators that lead to increased sensitivity to painful stimuli, and their inhibition represents a therapeutic approach in controlling acute and chronic pain. The water-soluble flavonone hesperidin methylchalcone (HMC) is used in the treatment of venous diseases, but its bioactivity as anti-inflammatory and analgesic is poorly understood. The present study evaluated the protective effects of HMC in widely used mouse models of acute and prolonged inflammation and pain.
    METHODS AND RESULTS:
    Male Swiss mice were treated with HMC (3-100 or 30 mg/kg, intraperitoneally) or vehicle (saline) 1h before inflammatory stimuli. In overt pain-like behavior tests, HMC inhibited acetic acid- and phenyl-p-benzoquinone-induced writhing, and capsaicin-, Complete Freund's Adjuvant (CFA)- and formalin-induced paw flinching and licking. HMC also inhibited carrageenan-, capsaicin- and CFA-induced mechanical and thermal hyperalgesia. Mechanistically, HMC inhibited carrageenan-induced cytokine (TNF-α, IL-1β, IL-6, and IL-10) production, oxidative stress and NF-κB activation. Furthermore, HMC did not cause gastric or hepatic injury in a 7 days treatment protocol.
    CONCLUSIONS:
    Thus, this is the first report that HMC reduces inflammation and inflammatory pain by targeting TRPV1 (transient receptor potential vanilloid type 1) receptor activity, oxidative stress, cytokine production, and NF-κB activity, which suggests its potential applicability in inflammatory diseases.
    J Cardiovasc Pharmacol. 1993 Aug;22(2):225-30.
    Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch.[Pubmed: 7692162]
    The Ruscus extract and the flavonoid Hesperidin methylchalcone (HMC) are used in treatment of venous insufficiency. In the present study, we used the hamster cheek pouch preparation and investigated the effects of these substances on increased microvascular permeability induced by bradykinin, histamine, and leukotriene B4 (LTB4) applied topically.
    METHODS AND RESULTS:
    Experiments were performed on male hamsters; 30 min after completion of the cheek pouch preparation, fluorescein-labeled dextran [molecular weight (mol wt) 150,000] was given intravenously (i.v.). Bradykinin, histamine, and LTB4 increased the number of fluorescent vascular leakage sites from postcapillary venules, evidence for an increase in macromolecular permeability, which was quantified in ultraviolet (UV)-light microscope as the number of leaky sites in the prepared area. Ruscus extract and HMC, given i.v., significantly inhibited the macromolecular permeability-increasing effect of bradykinin, LTB4, and histamine. Ruscus extract, applied topically, dose dependently inhibited the macromolecular permeability-increasing effect of histamine.
    CONCLUSIONS:
    Our results show that Ruscus extract and HMC have a protective effect against leakage of FITC-dextran in the cheek pouch after administration of various permeability-increasing substances, which further supports data previously reported on patients with venous insufficiency.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6011 mL 8.0053 mL 16.0105 mL 32.021 mL 40.0263 mL
    5 mM 0.3202 mL 1.6011 mL 3.2021 mL 6.4042 mL 8.0053 mL
    10 mM 0.1601 mL 0.8005 mL 1.6011 mL 3.2021 mL 4.0026 mL
    50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新橙皮苷二氢查尔酮; Neosperidin dihydrochalcone CFN98168 20702-77-6 C28H36O15 = 612.58 20mg QQ客服:215959384
    橙皮苷甲基查尔酮; Hesperidin methylchalcone CFN80405 24292-52-2 C29H36O15 = 624.59 20mg QQ客服:1413575084
    地奥司明杂质5; Diosmin Impurity 5 CFN95311 122087-66-5 C30H38O15 = 638.6 10mg QQ客服:2159513211
    二氢马里苷; Dihydromarein CFN90853 N/A C21H24O11 = 452.4 5mg QQ客服:215959384
    马里苷; Marein CFN90851 535-96-6 C21H22O11 = 450.4 10mg QQ客服:2056216494
    新异甘草苷; Neoisoliquiritin CFN90823 59122-93-9 C21H22O9 = 418.4 10mg QQ客服:215959384
    异甘草苷; Isoliquiritin CFN99155 5041-81-6 C21H22O9 = 418.39 20mg QQ客服:1413575084
    芹糖异甘草苷; Isoliquiritin apioside CFN90800 120926-46-7 C26H30O13 = 550.5 20mg QQ客服:2159513211
    弗罗利辛二水合物; Phlorizin dihydrate CFN90442 7061-54-3 C21H24O10.2H2O = 472.44 20mg QQ客服:1457312923
    Asebotin; Asebotin CFN96929 11075-15-3 C22H26O10 = 450.44 5mg QQ客服:1413575084

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