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  • 异莲心碱

    Isoliensinine

    异莲心碱
    产品编号 CFN99574
    CAS编号 6817-41-0
    分子式 = 分子量 C37H42N2O6 = 610.75
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The plantule of Nelumbo nucifera Gaertn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异莲心碱 CFN99574 6817-41-0 10mg QQ客服:2056216494
    异莲心碱 CFN99574 6817-41-0 20mg QQ客服:2056216494
    异莲心碱 CFN99574 6817-41-0 50mg QQ客服:2056216494
    异莲心碱 CFN99574 6817-41-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Organic Chemistry (China)
  • Istanbul University (Turkey)
  • Seoul National University of Science and Technology (Korea)
  • National Cancer Center Research Institute (Japan)
  • Weizmann Institute of Science (Israel)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Pretoria (South Africa)
  • Subang Jaya Medical Centre (Malaysia)
  • Universidade do Porto (Portugal)
  • University of Melbourne (Australia)
  • S.N.D.T. Women's University (India)
  • Pennsylvania State University (USA)
  • Max-Planck-Insitut (Germany)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2020, 21(24):9369.
  • Sci Rep. 2018, 1-9
  • Molecules2021, 26(1),230
  • J Sep Sci.2020, 201901140
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • J Mol Recognit.2020, 33(2):e2819
  • Journal of Functional Foods2022, 91:105019.
  • Planta Med.2023, a-2192-2281.
  • Molecules.2023, 28(19):6775.
  • J Biosci.2020, 45:46.
  • Food Res Int.2022, 157:111207.
  • Phytother Res.2019, 33(3):676-689
  • Toxicological Research2020, doi: 10.1007.
  • Nutrients.2019, 11(11):E2694
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Pharmacogn Mag.2015, 11:S585-91
  • J. of The Korean Society of Food Culture2017, 144-149
  • Sci Rep.2019, 9(1):4342
  • Separations2021, 8(1), 1.
  • Industrial Crops and Products2022, 186:115298
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Industrial Crops and Products2022, 188:115596.
  • Anticancer Res.2020, 40(10):5529-5538.
  • ...
  • 生物活性
    Description: Isoliensinine has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities, it inhibited TNF-alpha and TGF-beta 1; decreased the overexpression of growth factors Platelet-derived growth factor (PDGF)-beta, basic fibroblast growth factor (bFGF), proto-oncogene c-fos, c-myc and hsp70; and activated ROS and p38 MAPK/JNK .
    Targets: TNF-α | TGF-β/Smad | ROS | p38MAPK | JNK | HSP (e.g. HSP90)
    In vitro:
    Sci Rep. 2015 Jul 29;5:12579.
    Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation.[Pubmed: 26219228]
    Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed embryo of lotus (Nelumbo nucifera), and exhibit potential anti-cancer activity. Here, we explored the effects of these alkaloids on triple-negative breast cancer cells and found that among the three alkaloids isoliensinine possesses the most potent cytotoxic effect, primarily by inducing apoptosis.
    METHODS AND RESULTS:
    Interestingly, isoliensinine showed a much lower cytotoxicity against MCF-10A, a normal human breast epithelial cell line. Further studies showed that isoliensinine could significantly increase the production of reactive oxygen species (ROS) in triple-negative breast cancer cells, but not in MCF-10A cells. The isoliensinine-induced apoptosis could be attenuated by radical oxygen scavenger N-acetyl cysteine, suggesting that the cytotoxic effect of isoliensinine on cancer cells is at least partially achieved by inducing oxidative stress. We found that both p38 MAPK and JNK signaling pathways were activated by isoliensinine treatment and contributed to the induction of apoptosis. Furthermore, inhibitors or specific siRNAs of p38 MAPK and JNK could attenuate apoptosis induced by isoliensinine. However, only the p38 inhibitor or p38-specific siRNA blocked the elevation of ROS in isoliensinine-treated cells.
    CONCLUSIONS:
    Our findings thus revealed a novel antitumor effect of isoliensinine on breast cancer cells and may have therapeutic implications.
    Yao Xue Xue Bao. 2005 Feb;40(2):105-10.
    Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine.[Pubmed: 15875663]
    To investigate the inhibitory effects and mechanism of action of isoliensinine (IL) on the proliferation of porcine coronary arterial smooth muscle cells (CASMCs) induced by phenylephrine (Phen) and its mechanisms of action.
    METHODS AND RESULTS:
    MTT assay, immunohistochemical method and Western blotting were adopted. IL (0.03 - 3 micromol x L(-1)) could inhibit the CASMCs proliferation induced by Phen (0.1 micromol x L(-1)) in a concentration-dependent manner. IL (0.1 micromol x L(-1)) antagonized Phen-induced overexpression of PDGF-beta and bFGF from 0.545 +/- 0.026 and 0.47 +/- 0.03 to 0.458 +/- 0.019 and 0.376 +/- 0.017 (P < 0.01 , P < 0.01). IL (0.1 micromol x L(-1)) also decreased c-fos, c-myc and hsp70 overexpression induced by Phen from 0.57 +/- 0.04, 0.44 +/- 0.04 and (173 +/- 36)% to 0.46 +/- 0.05, 0.372 +/- 0.021 and (115 +/- 35)% respectively (P < 0.01, P < 0.01, P < 0.01).
    CONCLUSIONS:
    IL exerted antiproliferative effect on CASMCs induced by phenylephrine, and its mechanisms were related to decrease the overexpression of growth factors (PDGF-beta, bFGF), protooncogene (c-fos, c-myc) and hsp70.
    In vivo:
    Planta Med. 2005 Mar;71(3):225-30.
    Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice.[Pubmed: 15770542 ]
    The effects of isoliensinine (IL), a bisbenzylisoquinoline alkaloid extracted from the Chinese traditional medicine seed embryo of Nelumbo nucifera Gaertn., on bleomycin (BLM)-induced pulmonary fibrosis in mice were investigated.
    METHODS AND RESULTS:
    Seventy-two male Kungming mice were divided randomly into eight groups as BLM-IL10, BLM-IL20, BLM-IL40, BLM-Sal, Sal-IL10, Sal-IL20, Sal-IL40 and Sal-Sal groups. BLM (0.1 mg in 0.05 ml saline per animal, once) or saline (0.05 ml per animal, once) was applied intratracheally, and IL (10, 20, 40 mg/kg) or saline was administered orally 3 times per day in the appropriate groups. Animals were sacrificed 14 days after intratracheal treatment. Lung tissue and serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels, tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta 1 (TGF-beta (1)) were determined by biochemical measurements and immunohistochemistry. BLM treatment resulted in a significant increase of the hydroxyproline content and an obvious lung histological injury as compared to the Sal-Sal group. Administration of IL remarkably suppressed the increase in hydroxyproline content and abated the lung histological injury induced by BLM. There was a decrease in SOD activity and an increase in MDA level in lung tissue and serum in the BLM-Sal group (p < 0.01 , p < 0.01, vs. Sal-Sal group, respectively). And IL could obviously enhance the SOD activity and decrease the MDA level in a concentration-dependent manner. Moreover, IL also significantly inhibited the overexpression of TNF-alpha and TGF-beta (1) induced by BLM.
    CONCLUSIONS:
    These results indicated that IL possessed a significant inhibitory effect on BLM-induced pulmonary fibrosis, probably due to its antioxidant and/or anti-inflammatory activities and inhibitory overexpressing TNF-alpha and TGF-beta (1) induced by BLM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6373 mL 8.1867 mL 16.3733 mL 32.7466 mL 40.9333 mL
    5 mM 0.3275 mL 1.6373 mL 3.2747 mL 6.5493 mL 8.1867 mL
    10 mM 0.1637 mL 0.8187 mL 1.6373 mL 3.2747 mL 4.0933 mL
    50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.6549 mL 0.8187 mL
    100 mM 0.0164 mL 0.0819 mL 0.1637 mL 0.3275 mL 0.4093 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异莲心碱; Isoliensinine CFN99574 6817-41-0 C37H42N2O6 = 610.75 20mg QQ客服:215959384
    莲心碱高氯酸盐; Liensinine perchlorate CFN99578 2385-63-9 C37H42N2O6.ClHO4 = 711.20 20mg QQ客服:3257982914
    莲心碱二高氯酸盐; Liensinine diperchlorate CFN99579 5088-90-4 C37H42N2O6.(HClO4)2 = 811.67 20mg QQ客服:1413575084
    莲心碱; Liensinine CFN99580 2586-96-1 C37H42N2O6 = 610.75 20mg QQ客服:2056216494
    甲基莲心碱; Neferine CFN99581 2292-16-2 C38H44N2O6 = 624.77 20mg QQ客服:3257982914
    蝙蝠葛苏林碱; Daurisoline CFN90534 70553-76-3 C37H42N2O6 = 610.73 20mg QQ客服:2056216494
    去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline CFN90601 2831-75-6 C37H42N2O6 = 610.7 5mg QQ客服:1457312923
    蝙蝠葛碱; Dauricine CFN98129 524-17-4 C38H44N2O6 = 624.77 20mg QQ客服:2159513211
    Thalirugidine; Thalirugidine CFN89429 64215-95-8 C39H46N2O8 = 670.79 5mg QQ客服:1413575084
    盐酸吐根碱; Emetine Hydrochloride CFN90334 14198-59-5 C29H41ClN2O4 = 517.1 5mg QQ客服:1413575084

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