Info: Read More
  • 中药标准品生产商,产品定制服务
  • 蝙蝠葛苏林碱

    Daurisoline

    蝙蝠葛苏林碱
    产品编号 CFN90534
    CAS编号 70553-76-3
    分子式 = 分子量 C37H42N2O6 = 610.73
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Menispermum dauricum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蝙蝠葛苏林碱 CFN90534 70553-76-3 10mg QQ客服:2056216494
    蝙蝠葛苏林碱 CFN90534 70553-76-3 20mg QQ客服:2056216494
    蝙蝠葛苏林碱 CFN90534 70553-76-3 50mg QQ客服:2056216494
    蝙蝠葛苏林碱 CFN90534 70553-76-3 100mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Sapienza University of Rome (Italy)
  • Florida International University (USA)
  • Colorado State University (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Medical University of South Carolina (USA)
  • Julius Kühn-Institut (Germany)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of the Basque Country (Spain)
  • Ain Shams University (Egypt)
  • Mahidol University (Thailand)
  • Auburn University (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Sep Sci.2020, 201901140
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Plant Physiol Biochem.2023, 201:107795.
  • Biomolecules2021, 11(10),1513.
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Molecules.2018, 23(7):E1659
  • J Hematol Oncol.2018, 11(1):112
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Archives of Biological sciences2022, 00:21-21
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Oncotarget.2015, 6(31):30831-49
  • Nutr Cancer.2022, 1-13.
  • Biology (Basel).2020, 9(11):363.
  • Antiviral Res.2013, 98(3):386-93
  • LWT2021, 138:110397.
  • Molecules.2019, 24(6):E1177
  • Drug Chem Toxicol.2020, 1-14.
  • Food Funct.2022, 13(14):7638-7649.
  • Journal of Functional Foods2022, 98:105271.
  • Phytomedicine.2022, 100:154036.
  • ...
  • 生物活性
    Description: Daurisoline is a hERG inhibitor and also an autophagy blocker.Daurisoline has antiarrhythmic effects, it( at concentrations below 30 uM) exerts a blocking effect on hERG, but does not affect the expression and function of the hERG channel, it also can inhibit early afterdepolarizations (EADs) which may be associated with its blockade effects on I(Ca-L). Daurisoline and its isomers show cytoprotective effects on ischemic injury in cultured pheochromocytoma (PC12) cells, which are mediated by blocking Ca2+ influx into cells.
    Targets: Calcium Channel | Sodium Channel | Potassium Channel | hERG
    In vitro:
    Am J Chin Med. 2010;38(1):37-49.
    Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.[Pubmed: 20128043]
    Our previous studies have shown that Daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of Daurisoline on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by coarctating the abdominal aorta.
    METHODS AND RESULTS:
    The effects of Daurisoline on action potential duration (APD) and the incidences of EADs were studied in hypertrophied papillary muscles of rabbits in the conditions of low external K(+) concentration ([K(+)]o) and dofetilide (dof) by using standard microelectrode technique. The whole-cell patch clamp was used to record the L-type calcium current (I(Ca-L)) in isolated left ventricular cells of rabbits. The results showed that in hypertrophied papillary muscles of rabbits with low [K(+)]o ([K(+)]o = 2.7 mM), 1 microM dof prolonged APD(50) and APD(90) markedly and the incidence of EADs was 66.7% (4/6, p < 0.01); when 15 microM Daurisoline was applied, the incidence of EADs was 0% (0/4, p < 0.01) and the prolonged APD was shortened (p < 0.01). In a single myocyte, Daurisoline could also inhibit EADs induced by dof, low [K(+)]o and low external Mg(2+) concentration ([Mg(2+)]o) ([Mg(2+)](o) = 0.5 mM). Daurisoline could decrease the triangulation. In a single myocyte, Daurisoline could make the I-V curve upward, shift the steady-state activation curves to the right and the steady-state inactivation curves to the left and prolong the tau value of recovery curve obviously.
    CONCLUSIONS:
    These results suggested that Daurisoline could inhibit EADs which may be associated with its blockade effects on I(Ca-L).
    Zhongguo Yao Li Xue Bao. 1996 May;17(3):248-51.
    Effects of daurisoline on intracellular Ca2+ activity in myocardium.[Pubmed: 9812749]
    To explain the effect of daurisoline (DS) on delayed afterdepolarization (DAD).
    METHODS AND RESULTS:
    Ca(2+)-sensitive microelectrode technic was used to record intracellular Ca2+ activity (alpha Cai) and triggered activity (TA) arising from DAD in myocardium. Strophantin G 3 mumol.L-1 yielded an increase in resting myocardial alpha Cai by 0.19 +/- 0.11 mumol.L-1 and transient elevations of alpha Cai by 1.48 +/- 0.55 and 4.96 +/- 1.81 mumol.L-1, respectively during the development of DAD and TA. By pretreatment with DS or verapamil, strophantin G-caused elevations of the alpha Cai in resting and provoked myocardia were eliminated and TA disappeared. DS 50 mumol.L-1 reduced Na(+)-free medium-induced elevation of dog Purkinje fibrous alpha Cai and abolished caffeine-induced increase of dog myocardial alpha Cai.
    CONCLUSIONS:
    DS inhibited DAD and TA by preventing an increase of alpha Cai via transmembrane Ca2+ entry and Ca2+ release from the reticulum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6374 mL 8.1869 mL 16.3738 mL 32.7477 mL 40.9346 mL
    5 mM 0.3275 mL 1.6374 mL 3.2748 mL 6.5495 mL 8.1869 mL
    10 mM 0.1637 mL 0.8187 mL 1.6374 mL 3.2748 mL 4.0935 mL
    50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.655 mL 0.8187 mL
    100 mM 0.0164 mL 0.0819 mL 0.1637 mL 0.3275 mL 0.4093 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异莲心碱; Isoliensinine CFN99574 6817-41-0 C37H42N2O6 = 610.75 20mg QQ客服:1457312923
    莲心碱高氯酸盐; Liensinine perchlorate CFN99578 2385-63-9 C37H42N2O6.ClHO4 = 711.20 20mg QQ客服:215959384
    莲心碱二高氯酸盐; Liensinine diperchlorate CFN99579 5088-90-4 C37H42N2O6.(HClO4)2 = 811.67 20mg QQ客服:2056216494
    莲心碱; Liensinine CFN99580 2586-96-1 C37H42N2O6 = 610.75 20mg QQ客服:2056216494
    甲基莲心碱; Neferine CFN99581 2292-16-2 C38H44N2O6 = 624.77 20mg QQ客服:215959384
    蝙蝠葛苏林碱; Daurisoline CFN90534 70553-76-3 C37H42N2O6 = 610.73 20mg QQ客服:2056216494
    去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline CFN90601 2831-75-6 C37H42N2O6 = 610.7 5mg QQ客服:215959384
    蝙蝠葛碱; Dauricine CFN98129 524-17-4 C38H44N2O6 = 624.77 20mg QQ客服:3257982914
    Thalirugidine; Thalirugidine CFN89429 64215-95-8 C39H46N2O8 = 670.79 5mg QQ客服:2056216494
    盐酸吐根碱; Emetine Hydrochloride CFN90334 14198-59-5 C29H41ClN2O4 = 517.1 5mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产