蝙蝠葛苏林碱

Daurisoline

	产品编号	CFN90534
	CAS编号	70553-76-3
	分子式 = 分子量	C₃₇H₄₂N₂O₆ = 610.73
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Menispermum dauricum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
蝙蝠葛苏林碱	CFN90534	70553-76-3	10mg	QQ客服：3004468520
蝙蝠葛苏林碱	CFN90534	70553-76-3	20mg	QQ客服：3004468520
蝙蝠葛苏林碱	CFN90534	70553-76-3	50mg	QQ客服：3004468520
蝙蝠葛苏林碱	CFN90534	70553-76-3	100mg	QQ客服：3004468520

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Daurisoline is a hERG inhibitor and also an autophagy blocker.Daurisoline has antiarrhythmic effects, it( at concentrations below 30 uM) exerts a blocking effect on hERG, but does not affect the expression and function of the hERG channel, it also can inhibit early afterdepolarizations (EADs) which may be associated with its blockade effects on I(Ca-L). Daurisoline and its isomers show cytoprotective effects on ischemic injury in cultured pheochromocytoma (PC12) cells, which are mediated by blocking Ca2+ influx into cells.

Targets:

Calcium Channel | Sodium Channel | Potassium Channel | hERG

In vitro:

Am J Chin Med. 2010;38(1):37-49.

Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.[Pubmed: 20128043]

Our previous studies have shown that Daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of Daurisoline on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by coarctating the abdominal aorta.
METHODS AND RESULTS:
The effects of Daurisoline on action potential duration (APD) and the incidences of EADs were studied in hypertrophied papillary muscles of rabbits in the conditions of low external K(+) concentration ([K(+)]o) and dofetilide (dof) by using standard microelectrode technique. The whole-cell patch clamp was used to record the L-type calcium current (I(Ca-L)) in isolated left ventricular cells of rabbits. The results showed that in hypertrophied papillary muscles of rabbits with low [K(+)]o ([K(+)]o = 2.7 mM), 1 microM dof prolonged APD(50) and APD(90) markedly and the incidence of EADs was 66.7% (4/6, p < 0.01); when 15 microM Daurisoline was applied, the incidence of EADs was 0% (0/4, p < 0.01) and the prolonged APD was shortened (p < 0.01). In a single myocyte, Daurisoline could also inhibit EADs induced by dof, low [K(+)]o and low external Mg(2+) concentration ([Mg(2+)]o) ([Mg(2+)](o) = 0.5 mM). Daurisoline could decrease the triangulation. In a single myocyte, Daurisoline could make the I-V curve upward, shift the steady-state activation curves to the right and the steady-state inactivation curves to the left and prolong the tau value of recovery curve obviously.
CONCLUSIONS:
These results suggested that Daurisoline could inhibit EADs which may be associated with its blockade effects on I(Ca-L).

Zhongguo Yao Li Xue Bao. 1996 May;17(3):248-51.

Effects of daurisoline on intracellular Ca2+ activity in myocardium.[Pubmed: 9812749]

To explain the effect of daurisoline (DS) on delayed afterdepolarization (DAD).
METHODS AND RESULTS:
Ca(2+)-sensitive microelectrode technic was used to record intracellular Ca2+ activity (alpha Cai) and triggered activity (TA) arising from DAD in myocardium. Strophantin G 3 mumol.L-1 yielded an increase in resting myocardial alpha Cai by 0.19 +/- 0.11 mumol.L-1 and transient elevations of alpha Cai by 1.48 +/- 0.55 and 4.96 +/- 1.81 mumol.L-1, respectively during the development of DAD and TA. By pretreatment with DS or verapamil, strophantin G-caused elevations of the alpha Cai in resting and provoked myocardia were eliminated and TA disappeared. DS 50 mumol.L-1 reduced Na(+)-free medium-induced elevation of dog Purkinje fibrous alpha Cai and abolished caffeine-induced increase of dog myocardial alpha Cai.
CONCLUSIONS:
DS inhibited DAD and TA by preventing an increase of alpha Cai via transmembrane Ca2+ entry and Ca2+ release from the reticulum.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异莲心碱; Isoliensinine	CFN99574	6817-41-0	C₃₇H₄₂N₂O₆ = 610.75	20mg	QQ客服：3004468087
莲心碱高氯酸盐; Liensinine perchlorate	CFN99578	2385-63-9	C₃₇H₄₂N₂O₆.ClHO₄ = 711.20	20mg	QQ客服：3004468088
莲心碱二高氯酸盐; Liensinine diperchlorate	CFN99579	5088-90-4	C₃₇H₄₂N₂O₆.(HClO₄)₂ = 811.67	20mg	QQ客服：3004468091
莲心碱; Liensinine	CFN99580	2586-96-1	C₃₇H₄₂N₂O₆ = 610.75	20mg	QQ客服：3004468088
甲基莲心碱; Neferine	CFN99581	2292-16-2	C₃₈H₄₄N₂O₆ = 624.77	20mg	QQ客服：3004468520
蝙蝠葛苏林碱; Daurisoline	CFN90534	70553-76-3	C₃₇H₄₂N₂O₆ = 610.73	20mg	QQ客服：3004468091
去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline	CFN90601	2831-75-6	C₃₇H₄₂N₂O₆ = 610.7	5mg	QQ客服：3004468520
蝙蝠葛碱; Dauricine	CFN98129	524-17-4	C₃₈H₄₄N₂O₆ = 624.77	20mg	QQ客服：3004468520
Thalirugidine; Thalirugidine	CFN89429	64215-95-8	C₃₉H₄₆N₂O₈ = 670.79	5mg	QQ客服：3004468091
盐酸吐根碱; Emetine Hydrochloride	CFN90334	14198-59-5	C₂₉H₄₁ClN₂O₄ = 517.1	5mg	QQ客服：3004468087

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6374 mL	8.1869 mL	16.3738 mL	32.7477 mL	40.9346 mL
5 mM	0.3275 mL	1.6374 mL	3.2748 mL	6.5495 mL	8.1869 mL
10 mM	0.1637 mL	0.8187 mL	1.6374 mL	3.2748 mL	4.0935 mL
50 mM	0.0327 mL	0.1637 mL	0.3275 mL	0.655 mL	0.8187 mL
100 mM	0.0164 mL	0.0819 mL	0.1637 mL	0.3275 mL	0.4093 mL

蝙蝠葛苏林碱

Daurisoline

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