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  • 去甲山豆根碱 B; 蝙蝠葛诺林碱

    Daurinoline

    去甲山豆根碱 B; 蝙蝠葛诺林碱
    产品编号 CFN90601
    CAS编号 2831-75-6
    分子式 = 分子量 C37H42N2O6 = 610.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Euchresta japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去甲山豆根碱 B; 蝙蝠葛诺林碱 CFN90601 2831-75-6 1mg QQ客服:1457312923
    去甲山豆根碱 B; 蝙蝠葛诺林碱 CFN90601 2831-75-6 5mg QQ客服:1457312923
    去甲山豆根碱 B; 蝙蝠葛诺林碱 CFN90601 2831-75-6 10mg QQ客服:1457312923
    去甲山豆根碱 B; 蝙蝠葛诺林碱 CFN90601 2831-75-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Gyeongsang National University (Korea)
  • Nicolaus Copernicus Uniwersity (Poland)
  • National Chung Hsing University (Taiwan)
  • University of Wisconsin-Madison (USA)
  • Kyung Hee University (Korea)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Hamdard University (India)
  • Celltrion Chemical Research Institute (Korea)
  • Universidad Veracuzana (Mexico)
  • Monash University (Australia)
  • Massachusetts General Hospital (USA)
  • Chang Gung University (Taiwan)
  • Donald Danforth Plant Science Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants.2022, 11(3):592.
  • Phytother Res.2020, 34(4):788-795.
  • J Ethnopharmacol.2019, 236:31-41
  • Molecules.2022, 27(19):6681.
  • Plant Methods.2017, 13:108
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • PLoS One.2022, 17(6):e0268505.
  • J Insect Sci.2020, 20(5):18.
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Antioxidants (Basel).2022, 11(8):1471.
  • World J Mens Health.2019, 10.5534
  • Ann Transl Med.2019, 7(23):731
  • Biomimetics (Basel).2022, 7(4):154.
  • South African J of Botany2020, 135:50-57
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Molecules.2017, 22(12)
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Pharmaceutics.2021, 13(2):187.
  • Chem Biol Interact.2022, 368:110248.
  • J Chromatogr A.2022, 1685:463640.
  • Academic J of Second Military Medical University2018, 39(11)
  • Cells.2022, 11(6):931.
  • ...
  • 生物活性
    Description: Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
    Targets: 5-HT Receptor | Histamine Receptor | Calcium Channel
    In vivo:
    《Medical Journal of Wuhan University》 2011-01
    Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice[Reference: WebLink]
    To investigate the effect of Daurinoline on cerebral pia mater microcirculation in mice.
    METHODS AND RESULTS:
    An open cranial window was performed and microcirculation disturbance state was established by means of administering noradrenaline on the cerebral pia mater. The effect of Daurinoline was observed from the changes of the diameters and numbers of the arterioles and venules. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
    CONCLUSIONS:
    It suggests that Daurinoline would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury.
    Environ Toxicol Pharmacol . 2019 Feb;66:109-115.
    Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol[Pubmed: 30641414]
    Abstract Non-small cell lung cancer (NSCLC) is one of the most common malignancies, and Taxol is a cornerstone in the treatment. However, taxol-resistance eventually limits the clinical effects and applications. Daurinoline could restore the sensitivity of resistant MCF-7/adr and KBv200 cells. Whereas, the effect of daurinoline on the chemo-resistant NSCLC cells and the mechanism has not been elucidated. In this study, daurinoline was firstly demonstrated that inhibited the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells. And these effects were associated with EMT and Notch-1 reversal. Moreover, daurinoline could significantly enhance the anti-tumor effect of Taxol rather than epirubicin, adriamycin and cisplatin. And the reverse fold (RF) value of daurinoline was greater than terfenadine reported before. There are little cytotoxic effects of daurinoline and its derivatives reported by L.W. Fu, et al. (2001). Therefore, daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC patients. Keywords: Chemosensitization; Daurinoline; EMT; Non-small cell lung cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6375 mL 8.1873 mL 16.3747 mL 32.7493 mL 40.9366 mL
    5 mM 0.3275 mL 1.6375 mL 3.2749 mL 6.5499 mL 8.1873 mL
    10 mM 0.1637 mL 0.8187 mL 1.6375 mL 3.2749 mL 4.0937 mL
    50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.655 mL 0.8187 mL
    100 mM 0.0164 mL 0.0819 mL 0.1637 mL 0.3275 mL 0.4094 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异莲心碱; Isoliensinine CFN99574 6817-41-0 C37H42N2O6 = 610.75 20mg QQ客服:215959384
    莲心碱高氯酸盐; Liensinine perchlorate CFN99578 2385-63-9 C37H42N2O6.ClHO4 = 711.20 20mg QQ客服:1413575084
    莲心碱二高氯酸盐; Liensinine diperchlorate CFN99579 5088-90-4 C37H42N2O6.(HClO4)2 = 811.67 20mg QQ客服:1457312923
    莲心碱; Liensinine CFN99580 2586-96-1 C37H42N2O6 = 610.75 20mg QQ客服:2159513211
    甲基莲心碱; Neferine CFN99581 2292-16-2 C38H44N2O6 = 624.77 20mg QQ客服:2056216494
    蝙蝠葛苏林碱; Daurisoline CFN90534 70553-76-3 C37H42N2O6 = 610.73 20mg QQ客服:2159513211
    去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline CFN90601 2831-75-6 C37H42N2O6 = 610.7 5mg QQ客服:3257982914
    蝙蝠葛碱; Dauricine CFN98129 524-17-4 C38H44N2O6 = 624.77 20mg QQ客服:1413575084
    Thalirugidine; Thalirugidine CFN89429 64215-95-8 C39H46N2O8 = 670.79 5mg QQ客服:2056216494
    盐酸吐根碱; Emetine Hydrochloride CFN90334 14198-59-5 C29H41ClN2O4 = 517.1 5mg QQ客服:1413575084

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