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  • 蝙蝠葛碱

    Dauricine

    蝙蝠葛碱
    产品编号 CFN98129
    CAS编号 524-17-4
    分子式 = 分子量 C38H44N2O6 = 624.77
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Menispermum dauricum DC
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蝙蝠葛碱 CFN98129 524-17-4 10mg QQ客服:2159513211
    蝙蝠葛碱 CFN98129 524-17-4 20mg QQ客服:2159513211
    蝙蝠葛碱 CFN98129 524-17-4 50mg QQ客服:2159513211
    蝙蝠葛碱 CFN98129 524-17-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of South Australia (Australia)
  • Utrecht University (Netherlands)
  • Helmholtz Zentrum München (Germany)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Julius Kühn-Institut (Germany)
  • Weizmann Institute of Science (Israel)
  • Universidad Veracuzana (Mexico)
  • Washington State University (USA)
  • University of Sao Paulo (Brazil)
  • Sapienza University of Rome (Italy)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Indian Institute of Science (India)
  • Donald Danforth Plant Science Center (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Appl Pharm Sci.2022, 12(04):044-053
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Plos One.2019, 15(2):e0220084
  • Nutrients.2018, 11(1):E17
  • Separations2023, 10(11), 567;
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Biomol Ther (Seoul).2019, 10.4062
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Phytother Res.2022, ptr.7573.
  • Scientific World Journal.2014, 2014:654193
  • Industrial Crops and Products2022, 186:115298
  • Enzyme Microb Technol.2022, 153:109941.
  • Chung Shan Medical University2020, US20200323790A1
  • Nat Plants.2016, 3:16205
  • Drug Invention Today2019, 12(6):1303-1306
  • J Ethnopharmacol.2020, 269:113752.
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Comparative Clinical Pathology 2021, 30:961-971.
  • Int J Mol Sci.2022, 23(10):5468.
  • Int J Mol Sci.2022, 23(24):16000.
  • Applied Biological Chemistry2023, 66:42.
  • ...
  • 生物活性
    Description: Dauricine may has neuroprotective, and anti-tumor effects, it can pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of Dauricine across the blood‑brain barrier, it can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. Dauricine also has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A.
    Targets: P-gp | P450 (e.g. CYP17) | COX | c-Myc | p65 | Bcl-2/Bax | MMP(e.g.TIMP) | VEGFR | DNA/RNA Synthesis | NF-kB | Calcium Channel
    In vitro:
    Asian Pac J Trop Med. 2012 Dec;5(12):973-6.
    Dauricine can inhibit the activity of proliferation of urinary tract tumor cells.[Pubmed: 23199717]
    To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain, prostate cancer PC-3Mcell strain and primary cell culture system.
    METHODS AND RESULTS:
    The main effective component-phenolic alkaloids ofMenispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method. MTT method was used to detect dauricine anti-tumor effect. Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system. The minimum drug sensitivity concentration was between 3.81-5.15 μg/mL, and the inhibition ratio increased with the increase of concentration.
    CONCLUSIONS:
    Dauricine, the main effective component extracted from asiatic moonseed rhizome, had a good inhibition effect on tumor cells in urinary system. At the same time, Dauricine has certain inhibition effects on the primary cultured tumor cell.
    J Cell Physiol. 2010 Oct;225(1):266-75.
    Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells.[Pubmed: 20509140]
    Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine.
    METHODS AND RESULTS:
    In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-kappaB (NF-kappaB) activation in a dose- and time-dependent manner. Addition of dauricine inhibited the phosphorylation and degradation of IkappaBalpha, and the phosphorylation and translocation of p65. Moreover, dauricine down-regulated the expression of various NF-kappaB-regulated genes, including genes involved cell proliferation (cyclinD1, COX2, and c-Myc), anti-apoptosis (survivin, Bcl-2, XIAP, and IAP1), invasion (MMP-9 and ICAM-1), and angiogenesis (VEGF). In athymic nu/nu mouse model, we further demonstrated that dauricine significantly suppressed colonic tumor growth.
    CONCLUSIONS:
    Taken together, our results demonstrated that dauricine inhibited colon cancer cell proliferation, invasion, and induced cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. These findings provide evidence for a novel role of dauricine in preventing or treating colon cancer through modulation of NF-kappaB singling pathway.
    In vivo:
    Mol Med Rep. 2014 Mar;9(3):985-8.
    P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier.[Pubmed: 24378368]
    Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P‑glycoprotein in the transport of dauricine across the blood‑brain barrier by pre‑treatment with the P‑glycoprotein inhibitor verapamil.
    METHODS AND RESULTS:
    Sprague Dawley rats were divided into a verapamil group (pretreated with verapamil at a dose of 20 mg/kg) and a control group (pretreated with the same volume of normal saline). After 90 min, the animals were injected intravenously with dauricine (10 mg/kg). At 15, 30 and 60 min after dauricine administration, the levels of dauricine in the blood and brain were detected by high‑performance liquid chromatography. Compared with the control group, the dauricine concentration in the brains of the rats in the verapamil group was significantly increased. Furthermore, the brain‑plasma ratio of dauricine in the rats pretreated with verapamil was significantly higher than that of the animals in the control group. However, there was no difference identified between dauricine levels in the plasma of the verapamil and the control groups.
    CONCLUSIONS:
    The results indicated that dauricine is able to pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of dauricine across the blood‑brain barrier.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6006 mL 8.0029 mL 16.0059 mL 32.0118 mL 40.0147 mL
    5 mM 0.3201 mL 1.6006 mL 3.2012 mL 6.4024 mL 8.0029 mL
    10 mM 0.1601 mL 0.8003 mL 1.6006 mL 3.2012 mL 4.0015 mL
    50 mM 0.032 mL 0.1601 mL 0.3201 mL 0.6402 mL 0.8003 mL
    100 mM 0.016 mL 0.08 mL 0.1601 mL 0.3201 mL 0.4001 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异莲心碱; Isoliensinine CFN99574 6817-41-0 C37H42N2O6 = 610.75 20mg QQ客服:2159513211
    莲心碱高氯酸盐; Liensinine perchlorate CFN99578 2385-63-9 C37H42N2O6.ClHO4 = 711.20 20mg QQ客服:215959384
    莲心碱二高氯酸盐; Liensinine diperchlorate CFN99579 5088-90-4 C37H42N2O6.(HClO4)2 = 811.67 20mg QQ客服:215959384
    莲心碱; Liensinine CFN99580 2586-96-1 C37H42N2O6 = 610.75 20mg QQ客服:2056216494
    甲基莲心碱; Neferine CFN99581 2292-16-2 C38H44N2O6 = 624.77 20mg QQ客服:1457312923
    蝙蝠葛苏林碱; Daurisoline CFN90534 70553-76-3 C37H42N2O6 = 610.73 20mg QQ客服:1413575084
    去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline CFN90601 2831-75-6 C37H42N2O6 = 610.7 5mg QQ客服:3257982914
    蝙蝠葛碱; Dauricine CFN98129 524-17-4 C38H44N2O6 = 624.77 20mg QQ客服:1413575084
    Thalirugidine; Thalirugidine CFN89429 64215-95-8 C39H46N2O8 = 670.79 5mg QQ客服:1457312923
    盐酸吐根碱; Emetine Hydrochloride CFN90334 14198-59-5 C29H41ClN2O4 = 517.1 5mg QQ客服:3257982914

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