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  • 算盘子酮醇

    Glochidonol

    算盘子酮醇
    产品编号 CFN98248
    CAS编号 23963-54-4
    分子式 = 分子量 C30H48O2 = 440.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Flueggea virosa (Roxb. ex Willd.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    算盘子酮醇 CFN98248 23963-54-4 1mg QQ客服:2056216494
    算盘子酮醇 CFN98248 23963-54-4 5mg QQ客服:2056216494
    算盘子酮醇 CFN98248 23963-54-4 10mg QQ客服:2056216494
    算盘子酮醇 CFN98248 23963-54-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de La Salle (Mexico)
  • Aarhus University (Denmark)
  • St. Jude Children Research Hospital (USA)
  • Utrecht University (Netherlands)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Harvard University (USA)
  • Cornell University (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Institute of Chinese Materia Medica (China)
  • Technical University of Denmark (Denmark)
  • Biotech R&D Institute (USA)
  • Semmelweis Unicersity (Hungary)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Physiol Biochem.2021, 160:166-174.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • J Cell Biochem.2018, 119(2):2231-2239
  • J Ethnopharmacol.2016, 192:370-381
  • J Neuroinflammation.2020, 17(1):75.
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Nat Prod Commun.2014, 9(5):679-82
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Sci Rep.2023, 13(1):21690.
  • Nutrients.2021, 13(3):978.
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • J Ethnopharmacol.2016, 194:219-227
  • Molecules.2023, 28(9):3685.
  • Preprints2017, 2017120176
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Chem Biol Interact.2018, 283:59-74
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • ...
  • 生物活性
    Description: Glochidonol exhibits strong inhibitory effects against three human tumor cell lines, MCF-7, NCI-H-460 and SF-268, the GI(50) values of 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, respectively; it also exerts its antiproliferative activity through the involvement of apoptosis.
    In vitro:
    Planta Med. 2005 Mar;71(3):208-13.
    Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis.[Pubmed: 15770539]

    METHODS AND RESULTS:
    Six known lupanes lupenone ( 1), 3- epi-lupeol ( 2), glochidone ( 4), Glochidonol ( 5), glochidiol ( 6) and lup-20(29)-ene-1beta,3beta-diol ( 7) were isolated from the roots and stem wood of Glochidion eriocarpum and three, 5, 6 and lup-20(29)ene-3alpha,23-diol ( 3), were isolated from the roots and stem wood of Glochidion sphaerogynum. Compounds were identified by (1)H- and (13)C-NMR techniques. Triterpenes 2 - 7 were tested against the growth of three human tumor cell lines, MCF-7, NCI-H-460 and SF-268.
    CONCLUSIONS:
    Lupanes 3, 5, and 6 exhibited strong inhibitory effects against all three; thus GI (50) values for 3 were 12.7 +/- 3.7, 17.9 +/- 1.1 and 17.9 +/- 0.5, for 5 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, and for 6 6.63 +/- 0.7, 7.5 +/- 0.5 and 9.7 +/- 0.3.3. Epilupeol was less active, with GI (50) values of 75.6 +/- 11.7, 86.1 +/- 12.4 and 80.9 +/- 2.6 while 7 was moderately active only against MCF-7 (GI (50) = 79.2 +/- 2.4). Additional studies indicated that triterpenes 5 and 6 exerted their antiproliferative activity through the involvement of apoptosis while triterpene 3 did not.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2691 mL 11.3456 mL 22.6912 mL 45.3823 mL 56.7279 mL
    5 mM 0.4538 mL 2.2691 mL 4.5382 mL 9.0765 mL 11.3456 mL
    10 mM 0.2269 mL 1.1346 mL 2.2691 mL 4.5382 mL 5.6728 mL
    50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1346 mL
    100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 20mg QQ客服:1457312923
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:3257982914
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:2159513211
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:215959384
    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:2159513211
    2alpha-羟基羽扇豆醇; Lup-20(29)-ene-2alpha,3beta-diol CFN97717 61448-03-1 C30H50O2 = 442.73 5mg QQ客服:1413575084
    算盘子二醇; Glochidiol CFN97128 6610-56-6 C30H50O2 = 442.7 5mg QQ客服:1457312923
    3-表算盘子二醇; 3-Epiglochidiol CFN98360 29028-10-2 C30H50O2 = 442.7 5mg QQ客服:1457312923
    3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate CFN97122 6587-37-7 C34H54O4 = 526.8 5mg QQ客服:1413575084
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:2159513211

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