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  • 羽扇烯酮


    产品编号 CFN99681
    CAS编号 1617-70-5
    分子式 = 分子量 C30H48O = 424.7
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Pueraria thomsonii Benth.
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇烯酮 CFN99681 1617-70-5 10mg QQ客服:3257982914
    羽扇烯酮 CFN99681 1617-70-5 20mg QQ客服:3257982914
    羽扇烯酮 CFN99681 1617-70-5 50mg QQ客服:3257982914
    羽扇烯酮 CFN99681 1617-70-5 100mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Nicolaus Copernicus Uniwersity (Poland)
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  • University of Illinois (USA)
  • Helmholtz Zentrum München (Germany)
  • VIT University (India)
  • University of Liège (Belgium)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Lodz University of Technology (Poland)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universidad de Antioquia (Colombia)
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  • 生物活性
    Description: Lupenone and lupeol inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 uM, respectively, they are non−competitive inhibitors of PTP1B, and PTP1B appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. Lupenone stimulates melanogenesis by increasing the tyrosinase enzyme expression via mitogen-activated protein kinase phosphorylated extracellular signal-regulated kinases 1 and 2 phosphorylation inhibition. A 1 : 4 mixture of Lupenone and caryophyllene oxide shows trypanocidal activity.
    Targets: PPAR | ERK | MAPK | Antifection | PTP1B
    In vitro:
    Phytother Res. 2013 May;27(5):761-6.
    Lupenone isolated from Adenophora triphylla var. japonica extract inhibits adipogenic differentiation through the downregulation of PPARγ in 3T3-L1 cells.[Pubmed: 22848028]
    Adenophora triphylla var. japonica (Campanulaceae) is known to have anti-inflammatory and anti-tussive effects. Dysfunction of adipocytes and adipose tissue in obesity is related to various inflammatory cytokines or adipokines.
    In this study, we investigated whether lupenone isolated from A. triphylla var. japonica extract inhibits adipocyte differentiation and expression of adipogenic marker genes in 3T3-L1 preadipocytes. We demonstrated that lupenone resulted in a significant reduction in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, lupenone decreased the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) induced by troglitazone, and we also demonstrated that lupenone suppressed the PPARγ and CCAAT-enhancer-binding protein α (C/EBPα) protein levels.
    These findings demonstrated that lupenone isolated from A. triphylla var. japonica extract effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
    Evid Based Complement Alternat Med. 2013;2013:435398.
    Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.[Pubmed: 23762135]
    The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4  μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).
    Biomed Pharmacother . 2018 Jul;103:198-203.
    Beneficial health effects of lupenone triterpene: A review[Pubmed: 29653365]
    Abstract There are a large number of new structure compounds with good pharmacological activity in the natural plants, can be applied to the treatment of human diseases. Finding active ingredients from the plants is one of the important ways to develop new drugs. Triterpenes are widespread in plants, and lupenone belongs to lupane type triterpenoids. Lupenone is very common natural ingredient distributed in multi-family plants including Asteraceae, Balanophoraceae, Cactaceae, Iridaceae, Musaceae, Urticaceae, Leguminosae, Bombacaceae, etc., but its distribution has no regular. The consumption of lupenone in vegetarian diet is high in human life. Pharmacological screening of lupenone revealed various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity. Based on these important pharmacological activities, this review provides detailed account of pre-clinical studies conducted to determine the utility of lupenone as a therapeutic and chemopreventive agent for the treatment of various diseases. Keywords: Chagas disease; Diabetes; Inflammation; Lupenone; Tumor; Virus.
    In vivo:
    Mol Divers . 2020 Feb;24(1):21-30.
    Lupenone is a good anti-inflammatory compound based on the network pharmacology[Pubmed: 30796639]
    Abstract The dried rhizome of Musa basjoo Sieb. et Zucc. is Rhizoma Musae. It has been used to treat diabetes in Miao medicine in China. Lupenone was isolated from Rhizoma Musae and has good anti-diabetic activity. Its mechanism of action is unclear. Diabetes is a chronic low-level systemic inflammatory disease, and lupenone has anti-inflammatory activity, but the underlying mechanism is not fully elucidated. In this study, we aimed to construct the drug-target biologic network and predict the anti-inflammatory mechanism of lupenone. The network-based pharmacologic analysis platform was used to identify the target proteins related to inflammation. Furthermore, the effects of lupenone on acute, subacute and diabetic pancreatic inflammation were evaluated. The "component-target-disease" network was constructed using Cytoscape. Lupenone could regulate transcription factor p65, NF-kappa-B inhibitor alpha, transcription factor AP-1, NF-kappa-B essential modulator, nuclear factor NF-kappa-B p105 subunit, epidermal growth factor receptor, hypoxia-inducible factor 1-alpha and other proteins related to the PI3K-Akt, Toll-like receptor and NF-kappa B signaling pathways. In addition, lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1β and IFN-γ levels in the pancreas of diabetic rats. The above results provide strong support for studying the molecular mechanism of lupenone in the treatment of diabetes from the perspective of anti-inflammation. Keywords: Diabetes; Inflammation; Lupenone; Network pharmacology; Pancreas; Target.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3546 mL 11.773 mL 23.546 mL 47.0921 mL 58.8651 mL
    5 mM 0.4709 mL 2.3546 mL 4.7092 mL 9.4184 mL 11.773 mL
    10 mM 0.2355 mL 1.1773 mL 2.3546 mL 4.7092 mL 5.8865 mL
    50 mM 0.0471 mL 0.2355 mL 0.4709 mL 0.9418 mL 1.1773 mL
    100 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.4709 mL 0.5887 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:1457312923
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:1457312923
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:1413575084
    算盘子酮醇; Glochidonol CFN98248 23963-54-4 C30H48O2 = 440.7 5mg QQ客服:2159513211
    算盘子酮; Glochidone CFN97127 6610-55-5 C30H46O = 422.7 5mg QQ客服:215959384
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 20mg QQ客服:2159513211
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:3257982914
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:2056216494
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:1457312923
    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:1457312923





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