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  • 算盘子二醇

    Glochidiol

    算盘子二醇
    产品编号 CFN97128
    CAS编号 6610-56-6
    分子式 = 分子量 C30H50O2 = 442.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Glochidion puberum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    算盘子二醇 CFN97128 6610-56-6 1mg QQ客服:2159513211
    算盘子二醇 CFN97128 6610-56-6 5mg QQ客服:2159513211
    算盘子二醇 CFN97128 6610-56-6 10mg QQ客服:2159513211
    算盘子二醇 CFN97128 6610-56-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Helsinki (Finland)
  • Universite Libre de Bruxelles (Belgium)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Chang Gung University (Taiwan)
  • Aveiro University (Portugal)
  • Lund University (Sweden)
  • Ain Shams University (Egypt)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Medical University of Gdansk (Poland)
  • University of Madras (India)
  • Colorado State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT2021, 147:111620.
  • Anal Chim Acta.2018, 1039:162-171
  • Postharvest Biol Tec2019, 149:18-26
  • Processes2021, 9(1), 153.
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Mol Recognit.2020, 33(2):e2819
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • J Food Sci.2021, 86(9):3810-3823.
  • Universitat Stuttgart2022, opus-12200.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Appl. Sci.2020, 10(5),1713.
  • BMC Complement Altern Med.2018, 18(1):303
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Biomed Chromatogr.2020, e5021.
  • J Ethnopharmacol.2022, 291:115159.
  • Korean J Acupunct2020, 37:104-121
  • Phytother Res.2022, 35844057.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Molecules 2021, 26(4),1092.
  • Int J Mol Sci.2020, 21(6):2190.
  • Food Funct.2021, 12(13):5892-5902.
  • ...
  • 生物活性
    Description: Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor promotion in an in vivo mouse two-stage carcinogenesis test. Glochidiol (IC50 = 290 mol ratio/32 pmol TPA) also shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA).
    In vitro:
    Planta Med. 2004 Dec;70(12):1234-6.
    Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem bark of Glochidion zeylanicum and Phyllanthus flexuosus.[Pubmed: 15643564]

    METHODS AND RESULTS:
    Four known lupane-type triterpenoids, glochidonol (1), Glochidiol (2), lup-20(29)-ene-1beta,3beta-diol (3) and glochidone (3) were isolated from the stem bark of Glochidion zeylanicum. Previously, lupeol (5), lup-20(29)-ene-3beta,24-diol (6) and betulin (7) were isolated from the stem bark of Phyllanthus flexuosus. This study reports the assays of these lupane-type triterpenoids: all isolates 1-7 and synthetic analogues, glochidonyl acetate (1a), lup-20(29)-ene-1,3-dione (1b) and lup-20(29)-ene 3beta,24-diacetate (6a) were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA).
    CONCLUSIONS:
    Among them, the effects of compounds 2 (IC50 = 290 mol ratio/32 pmol TPA) and 3 (IC50 = 300) were stronger than the others. In addition, compound 2 exhibited a strong inhibitory effect on mouse skin tumor promotion in an in vivo mouse two-stage carcinogenesis test.
    Planta Med. 2005 Mar;71(3):208-13.
    Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis.[Pubmed: 15770539]

    METHODS AND RESULTS:
    Six known lupanes lupenone ( 1), 3- epi-lupeol ( 2), glochidone ( 4), glochidonol ( 5), Glochidiol ( 6) and lup-20(29)-ene-1beta,3beta-diol ( 7) were isolated from the roots and stem wood of Glochidion eriocarpum and three, 5, 6 and lup-20(29)ene-3alpha,23-diol ( 3), were isolated from the roots and stem wood of Glochidion sphaerogynum. Compounds were identified by (1)H- and (13)C-NMR techniques. Triterpenes 2 - 7 were tested against the growth of three human tumor cell lines, MCF-7, NCI-H-460 and SF-268.
    CONCLUSIONS:
    Lupanes 3, 5, and 6 exhibited strong inhibitory effects against all three; thus GI (50) values for 3 were 12.7 +/- 3.7, 17.9 +/- 1.1 and 17.9 +/- 0.5, for 5 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, and for 6 6.63 +/- 0.7, 7.5 +/- 0.5 and 9.7 +/- 0.3.3. Epilupeol was less active, with GI (50) values of 75.6 +/- 11.7, 86.1 +/- 12.4 and 80.9 +/- 2.6 while 7 was moderately active only against MCF-7 (GI (50) = 79.2 +/- 2.4). Additional studies indicated that triterpenes 5 and 6 exerted their antiproliferative activity through the involvement of apoptosis while triterpene 3 did not.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2589 mL 11.2943 mL 22.5887 mL 45.1773 mL 56.4717 mL
    5 mM 0.4518 mL 2.2589 mL 4.5177 mL 9.0355 mL 11.2943 mL
    10 mM 0.2259 mL 1.1294 mL 2.2589 mL 4.5177 mL 5.6472 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:215959384
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:2932563308
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:215959384
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:3257982914
    算盘子酮醇; Glochidonol CFN98248 23963-54-4 C30H48O2 = 440.7 5mg QQ客服:2159513211
    算盘子酮; Glochidone CFN97127 6610-55-5 C30H46O = 422.7 5mg QQ客服:1148253675
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 10mg QQ客服:2932563308
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:1413575084
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:2159513211
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:2159513211

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