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  • 羽扇豆醇 3-乙酸酯

    Lupeol acetate

    羽扇豆醇 3-乙酸酯
    产品编号 CFN96583
    CAS编号 1617-68-1
    分子式 = 分子量 C32H52O2 = 468.77
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The stem barks of Himatanthus drasticus (Mart.) Plumel.
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 1mg QQ客服:215959384
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 5mg QQ客服:215959384
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 10mg QQ客服:215959384
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • Shanghai University of TCM (China)
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  • ...
  • 生物活性
    Description: Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone. Lupeol acetate can significantly improve the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.
    Targets: TNF-α | NO | NOS | COX | PGE
    In vivo:
    Pharmacology. 2005 Oct;75(2):57-62.
    Induction of antifertility with lupeol acetate in male albino rats.[Pubmed: 16015025 ]
    The present study was undertaken to evaluate the antifertility activity of the active principle, i.e. lupeol acetate, isolated from benzene extract of Alstonia scholaris in male albino rats.
    The treatment with lupeol acetate at the dose level of 10 mg/rat/day did not cause any significant change in the body weights, but significant reduction in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate, was observed. Testicular sperm count, epididymal sperm count and motility were found significantly declined when compared with controls, which resulted in reduction of male fertility by 100%. Arrest of spermatogenesis was noted at various stages with production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids were decreased by 52.36, 54.91, 55.67 and 69.65%, respectively. The seminiferous tubules appeared reduced in size by 24.62%. Cross-sectional surface area of Sertoli cells as well as their counts were found to be significantly depleted. Leydig cell nuclear area and number of mature Leydig cells were decreased by 27.65 and 35.47%. Biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose also showed significant reduction.
    Evid Based Complement Alternat Med. 2012;2012:371273.
    Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro.[Pubmed: 23243439 ]
    Aims of the present study were to investigate effects of Balanophora spicata (BS) on antinociception and anti-inflammation both in vivo and in vitro.
    Crude extract of BS inhibited vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2), but not by PAF. Furthermore, BS crude extract, different layers (n-hexane, ethyl acetate, n-butanol, and water layer), and Lupeol acetate had significant antinociceptive and anti-inflammatory effects on acetic acid-induced abdominal writhing response, formalin-induced licking behavior, carrageenan-, and serotonin-induced paw edema. The n-hexane layer had the most effective potency among all layers (IC50: 67.33 mg/kg on writhing response; IC50s: 34.2 mg/kg and 21.29 mg/kg on the early phase and late phase of formalin test, resp.). Additionally, Lupeol acetate which was isolated from the n-hexane layer of BS effectively inhibited the acetic acid-induced writhing response (IC50: 28.32 mg/kg), formalin-induced licking behavior (IC50: 20.95 mg/kg), NO production (IC50: 4.102 μM), iNOS expression (IC50: 5.35 μM), and COX2 expression (IC50: 5.13 μM) in LPS-stimulated RAW 264.7 cells.
    In conclusion, BS has antinociceptive and anti-inflammatory effects which may be partially due to the inhibition of changes in vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2) and the attenuation of iNOS and COX-2 expression.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1332 mL 10.6662 mL 21.3324 mL 42.6648 mL 53.3311 mL
    5 mM 0.4266 mL 2.1332 mL 4.2665 mL 8.533 mL 10.6662 mL
    10 mM 0.2133 mL 1.0666 mL 2.1332 mL 4.2665 mL 5.3331 mL
    50 mM 0.0427 mL 0.2133 mL 0.4266 mL 0.8533 mL 1.0666 mL
    100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.4266 mL 0.5333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate CFN97122 6587-37-7 C34H54O4 = 526.8 5mg QQ客服:215959384
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:2932563308
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:1148253675
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:215959384
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:1413575084
    算盘子酮醇; Glochidonol CFN98248 23963-54-4 C30H48O2 = 440.7 5mg QQ客服:3257982914
    算盘子酮; Glochidone CFN97127 6610-55-5 C30H46O = 422.7 5mg QQ客服:2932563308
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 10mg QQ客服:3257982914
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:3257982914
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:3257982914





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