Info: Read More
  • 中药标准品生产商,产品定制服务
  • 人参皂苷F2

    Ginsenoside F2

    人参皂苷F2
    产品编号 CFN99755
    CAS编号 62025-49-4
    分子式 = 分子量 C42H72O13 = 785.01
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷F2 CFN99755 62025-49-4 10mg QQ客服:2056216494
    人参皂苷F2 CFN99755 62025-49-4 20mg QQ客服:2056216494
    人参皂苷F2 CFN99755 62025-49-4 50mg QQ客服:2056216494
    人参皂苷F2 CFN99755 62025-49-4 100mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of South Carolina (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Stirling (United Kingdom)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • S.N.D.T. Women's University (India)
  • Michigan State University (USA)
  • FORTH-IMBB (Greece)
  • University of Hull (United Kingdom)
  • University of Lodz (Poland)
  • Monash University (Australia)
  • VIT University (India)
  • Universidade do Porto (Portugal)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Vietnam J. Chemistry2022, 60(2):211-222
  • J Ethnopharmacol.2019, 236:31-41
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Nutrients.2017, 10(1)
  • Nutrients.2022, 14(19):4170.
  • Oxid Med Cell Longev2020, 12
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Plant Archives2020, 2(1),2929-2934
  • Sci Rep.2019, 9(1):6429
  • Antioxidants (Basel).2022, 11(12):2327.
  • J Appl Biol Chem2022, 65:343−348.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Front Plant Sci.2020, 10:1705
  • Arch Biochem Biophys.2020, 687:108363.
  • Int J Mol Sci.2017, 19(1)
  • Heliyon.2023, e12778.
  • Molecules.2023, 28(16):6025.
  • Nat Prod Sci.2019, 25(3):238
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • BMC Cancer. 2021, 21(1):91.
  • Ind Crops Prod.2015, 67:185-191
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Oncotarget.2017, 8(53):90925-90947
  • ...
  • 生物活性
    Description: Ginsenoside F2, an autophagic initiater, which has anti-cancer, and anti-obesity activities. Ginsenoside F2 inhibited the growth and invasion of cancer, and activated the intrinsic apoptotic pathway and mitochondrial dysfunction. Ginsenoside F2 suppresses hair cell apoptosis and premature entry to catagen more effectively than finasteride, it decreases the expression of TGF-β2 and SCAP proteins, the factors in the SCAP pathway could be targets for hair loss prevention drugs.
    Targets: PPAR | TGF-β/Smad | Wnt/β-catenin | Caspase | MMP(e.g.TIMP)
    In vitro:
    J Ginseng Res. 2012 Jan; 36(1): 86–92.
    Anti-Cancer Effect of Ginsenoside F2 against Glioblastoma Multiforme in Xenograft Model in SD Rats[Pubmed: 23717108]
    The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short.
    METHODS AND RESULTS:
    Therefore, this study was conducted to assess the potential of ginsenoside F2 (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC50 of 50 μg/mL through apoptosis, confirmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced.
    METHODS AND RESULTS:
    The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
    In vivo:
    Eur J Pharmacol. 2014 May 5;730:82-9.
    The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin.[Pubmed: 24613976]
    This study was conducted to confirm the possibility of using minor ginseng saponin F2 by oral administration on hair anagen induction effects.
    METHODS AND RESULTS:
    The signaling pathway and anagen induction effect of ginsenoside F2 were investigated and compared with finasteride on the effect of hair growth induction. The cell-based MTT assay results indicated that the proliferation rates of HHDPC and HaCaT treated with F2 significantly increased by 30% compared with the finasteride-treated group. A western blot study showed that the expression of β-catenin Lef-1 and DKK-1 increased by 140, 200% and decreased by 40% in the F2-treated group, respectively compared to that of finasteride-treated group. C57BL/6 mice were subjected to the same treatments. The hair growth promotion rates were compared with groups treated with finasteride, which was 20% higher in the F2-treated group. Tissue histological analysis results showed the number of hair follicles, thickness of the epidermis, and follicles of the anagen phase which increased in the F2-treated group, compared with the finasteride-treated groups. Moreover, the effect of F2 on hair growth was confirmed through the immunofluorescence (IF) methods indicating the expression aspect of Wnt signal pathway-related factors in the tissue of C57BL/6 mouse.
    CONCLUSIONS:
    Our results considered the expression increase in β-catenin, Lef-1 which was suggested as a major factor related to the development and growth of hair follicle and the decrease in DKK-1 when entering catagen by F2. As the data showed, F2 might be a potential new therapeutic source for anagen induction and hair growth through the Wnt signal pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2739 mL 6.3693 mL 12.7387 mL 25.4774 mL 31.8467 mL
    5 mM 0.2548 mL 1.2739 mL 2.5477 mL 5.0955 mL 6.3693 mL
    10 mM 0.1274 mL 0.6369 mL 1.2739 mL 2.5477 mL 3.1847 mL
    50 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5095 mL 0.6369 mL
    100 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.2548 mL 0.3185 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    达玛-20(22),24-二烯-3β,6α,12β-三醇; Quasipanaxatriol CFN95248 171903-78-9 C30H50O3 = 458.7 5mg QQ客服:3257982914
    人参皂苷MC; Ginsenoside MC CFN95232 175484-06-7 C41H70O12 = 755.0 10mg QQ客服:1457312923
    Gynosaponin I; Gynosaponin I CFN96182 1207861-69-5 C42H72O12 = 769.0 5mg QQ客服:1457312923
    人参皂苷TN2; Gynosaponin TN2 CFN95331 77658-95-8 C42H72O13 = 785.0 5mg QQ客服:215959384
    人参皂苷F2; Ginsenoside F2 CFN99755 62025-49-4 C42H72O13 = 785.01 20mg QQ客服:3257982914
    人参皂苷Rd2; Ginsenoside Rd2 (Quinquenoside L10) CFN95231 83480-64-2 C47H80O17 = 917.2 10mg QQ客服:2159513211
    七叶胆苷XVI; Gypenoside XVII CFN90193 80321-69-3 C48H82O18 = 947.16 20mg QQ客服:2159513211
    三七皂苷L13; Notoginsenoside L13 CFN95332 2485859-56-9 C47H78O17 = 915.1 5mg QQ客服:2159513211
    人参皂苷Rb2; Ginsenoside Rb2 CFN99965 11021-13-9 C53H90O22 = 1079.27 20mg QQ客服:215959384
    人参皂苷Rb3; Ginsenoside Rb3 CFN99966 68406-26-8 C53H90O22 = 1079.27 20mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产