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  • 人参皂苷F1

    Ginsenoside F1

    产品编号 CFN99754
    CAS编号 53963-43-2
    分子式 = 分子量 C36H62O9 = 638.88
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C.A.Mey.
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷F1 CFN99754 53963-43-2 10mg QQ客服:1413575084
    人参皂苷F1 CFN99754 53963-43-2 20mg QQ客服:1413575084
    人参皂苷F1 CFN99754 53963-43-2 50mg QQ客服:1413575084
    人参皂苷F1 CFN99754 53963-43-2 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • 生物活性
    Description: Ginsenoside has been reported to suppress platelet aggregation and to reduce gap junction-mediated intercellular communication, also as a novel anti-skin cancer drug with anti-proliferative and anti-migration features. Ginsenoside F1 has a potential for industrial cosmetic materials, it also has inhibitory effect of elastase and tyrosinase, it significantly reduces ultraviolet-B-induced cell death by maintaining constant levels of Bcl-2 and protects HaCaT cells from apoptosis caused by ultraviolet B irradiation.
    Targets: IL Receptor | Bcl-2/Bax
    In vitro:
    Exp Dermatol. 2014 Nov;23(11):860-2.
    Role of epidermal γδ T-cell-derived interleukin 13 in the skin-whitening effect of Ginsenoside F1.[Pubmed: 25091975]
    Ginsenoside F1 (GF1) is a metabolite of ginsenoside Rg1. Although Ginsenoside F1 has several benefits for skin physiology, the effect of Ginsenoside F1 on skin pigmentation has not been reported.
    We found that a cream containing 0.1% Ginsenoside F1 showed a significant whitening effect on artificially tanned human skin after 8 weeks of application. However, Ginsenoside F1 did not inhibit mRNA expression of tyrosinase or dopachrome tautomerase (DCT) in normal human epidermal melanocytes (NHEMs) or cocultured NHEMs/normal human epidermal keratinocytes. Interestingly, Ginsenoside F1 enhanced production of interleukin 13 (IL-13) from human epidermal γδ T cells. IL-13 significantly reduced the mRNA expression and protein amount of both tyrosinase and DCT and reduced melanin synthesis activities in NHEMs, resulting in visible brightening of NHEM pellet.
    These results suggest that enhancement of IL-13 production by Ginsenoside F1 from epidermal γδ T cells might play a role in the skin-whitening effect of GF1 via the suppression of tyrosinase and DCT.
    J. Ginseng Res., 2011, 35(1):86-91.
    Ginsenoside F1 Modulates Cellular Responses of Skin Melanoma Cells.[Reference: WebLink]
    Ginsenoside F1 (G-F1) is an enzymatic metabolite generated from G-Rg1. Although this metabolite has been reported to suppress platelet aggregation and to reduce gap junction-mediated intercellular communication, the modulatory activity of G-F1 on the functional role of skin-derived cells has not yet been elucidated.
    In this study, we evaluated the regulatory role of G-F1 on the cellular responses of B16 melanoma cells. G-F1 strongly suppressed the proliferation of B16 cells up to 60% at 200 ug/mL, while only diminishing the viability of HEK293 cells up to 30%. Furthermore, G-F1 remarkably induced morphological change and clustering of B16 melanoma cells. The melanin production of B16 cells was also significantly blocked by G-F1 up to 70%. Interestingly, intracellular signaling events involved in cell proliferation, migration, and morphological change were up-regulated at 1 h incubation but down-regulated at 12 h.
    Therefore, our results suggest that G-F1 can be applied as a novel anti-skin cancer drug with anti-proliferative and anti-migration features.
    Korean Journal of Pharmacognosy, 2013, 44(1):10-15.
    Inhibitory effect of elastase and tyrosinase of ginsenoside F1 isolated from Panax ginseng leaves[Reference: WebLink]
    This study was carried to establish a simple isolation and purification method of Ginsenoside F1 from leaves of Panax ginseng and was to evaluate the inhibitory effect of purified Ginsenoside F1 on the activities of elastase and tyrosinase.
    The content of Ginsenoside F1 was 90-fold higher in leaves than in root of ginseng. Ginsenoside F1 was isolated from EtOAc fraction between EtOAc and alkalized water of 80% EtOH extract after remove of hydrophobic components. The 50% inhibitory concentration (IC50) of Ginsenoside F1 on elastase activity and tyrosinase activity was 1.07 mM and 1.81 mM, respectively. Especially, inhibitory effect of Ginsenoside F1 on tyrosinase activity was higher than that of arbutin (IC50; 2.20 mM).
    These results indicate that Ginsenoside F1 have a potential for industrial cosmetic materials.
    2018 Jan;42(1):42-49.
    Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells[Pubmed: 29348721]
    Abstract Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransferase enzyme. Glycosylation has the advantage of synthesizing rare chemical compounds from common compounds with great ease. Methods: UDP-glycosyltransferase (BSGT1) gene from Bacillus subtilis was selected for cloning. The recombinant glycosyltransferase enzyme was purified, characterized, and utilized to enzymatically transform F1 into its derivative. The new product was characterized by NMR techniques and evaluated by MTT, melanin count, and tyrosinase inhibition assay. Results: The new derivative was identified as (20S)-3β,6α,12β,20-tetrahydroxydammar-24-ene-20-O-β-D-glucopyranosyl-3-O-β-D-glucopyranoside (ginsenoside Ia), which possesses an additional glucose linked into the C-3 position of substrate F1. Ia had been previously reported; however, no in vitro biological activity was further examined. This study focused on the mass production of arduous ginsenoside Ia from accessible F1 and its inhibitory effect of melanogenesis in B16BL6 cells. Ia showed greater inhibition of melanin and tyrosinase at 100 μmol/L than F1 and arbutin. These results suggested that Ia decreased cellular melanin synthesis in B16BL6 cells through downregulation of tyrosinase activity. Conclusion: To our knowledge, this is the first study to report on the mass production of rare ginsenoside Ia from F1 using recombinant UDP-glycosyltransferase isolated from B. subtillis and its superior melanogenesis inhibitory activity in B16BL6 cells as compared to its precursor. In brief, ginsenoside Ia can be applied for further study in cosmetics. Keywords: B16BL6 cell line; UDP-glycosyltransferase; ginsenoside F1; ginsenoside Ia; melanogenesis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5652 mL 7.8262 mL 15.6524 mL 31.3048 mL 39.131 mL
    5 mM 0.313 mL 1.5652 mL 3.1305 mL 6.261 mL 7.8262 mL
    10 mM 0.1565 mL 0.7826 mL 1.5652 mL 3.1305 mL 3.9131 mL
    50 mM 0.0313 mL 0.1565 mL 0.313 mL 0.6261 mL 0.7826 mL
    100 mM 0.0157 mL 0.0783 mL 0.1565 mL 0.313 mL 0.3913 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七皂苷Fc; Notoginsenoside Fc CFN93283 88122-52-5 C58H98O26 = 1211.4 20mg QQ客服:3257982914
    人参皂苷Rb1; Ginsenoside Rb1 CFN99964 41753-43-9 C54H92O23 = 1109.29 20mg QQ客服:1413575084
    三七皂苷Fa; Notoginsenoside Fa CFN93284 88100-04-3 C59H100O27 = 1241.4 20mg QQ客服:1457312923
    三七皂苷R4; Notoginsenoside R4 CFN91142 87741-77-3 C59H100O27 = 1241.4 5mg QQ客服:215959384
    人参皂苷Ra2; Ginsenoside Ra2 CFN93293 83459-42-1 C58H98O26 = 1211.39 5mg QQ客服:3257982914
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:3257982914
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:215959384
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:1457312923
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 1881225-08-6 C38H64O10 = 680.9 5mg QQ客服:2159513211
    人参皂苷F3; Ginsenoside F3 CFN99978 62025-50-7 C41H70O13 = 770.99 20mg QQ客服:1457312923





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