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  • 人参皂苷Rc

    Ginsenoside Rc

    人参皂苷Rc
    产品编号 CFN99973
    CAS编号 11021-14-0
    分子式 = 分子量 C53H90O22 = 1079.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rc CFN99973 11021-14-0 10mg QQ客服:2159513211
    人参皂苷Rc CFN99973 11021-14-0 20mg QQ客服:2159513211
    人参皂苷Rc CFN99973 11021-14-0 50mg QQ客服:2159513211
    人参皂苷Rc CFN99973 11021-14-0 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universita' Degli Studi Di Cagliari (Italy)
  • Institute of Chinese Materia Medica (China)
  • University of Padjajaran (Indonesia)
  • Washington State University (USA)
  • University of Illinois (USA)
  • University of Maryland (USA)
  • University of Beira Interior (Portugal)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Universidade Católica Portuguesa (Portugal)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Charles University in Prague (Czech Republic)
  • Universidade do Porto (Portugal)
  • Monash University Malaysia (Malaysia)
  • Chiang Mai University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Med.2020, 74(1):65-75
  • The Journal of Supercritical Fluids2021, 176:105305.
  • J Agric Food Chem.2018, 66(1):351-358
  • ACS Nano.2018, 12(4):3385-3396
  • J Nat Prod.2021, 84(9):2544-2553.
  • J Nat Med.2017, 71(2):380-388
  • Front Pharmacol.2021, 12:607403.
  • Plant Archives2020, 2(1),2929-2934
  • Anat Rec2018, 24264
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Sci Rep. 2017, 12953(7)
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Phytomedicine.2022, 96:153877.
  • BMC Complement Altern Med.2014, 14:242
  • Front Plant Sci.2021, 12: 648426.
  • Toxicol In Vitro.2022, 81:105346.
  • Food Res Int.2020, 128:108778
  • American Association for Anatomy2020, doi: 10.1002.
  • Int J Mol Sci.2021, 22(19):10220.
  • Biology (Basel).2020, 9(11):363.
  • Front Pharmacol.2021, 12:765521.
  • J Pharm Biomed Anal.2016, 129:50-59
  • Cancers (Basel).2023, 15(1):293.
  • ...
  • 生物活性
    Description: Ginsenoside Rc exhibits anti-diabetic, anti-adipogenic, anticancer and anti-inflammatory activities; it can attenuate inflammatory symptoms of gastritis, hepatitis and arthritis, and it can significantly enhance glucose uptake by inducing ROS generation, which leads to AMPK and p38 MAPK activation. Rc enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA), it also inhibits the expression of TNF-α and IL-1β.
    Targets: PPAR | AP-1 | PI3K | Akt | AMPK | PKB | p38MAPK | ROS | IL Receptor | cAMP | TNF-α | NF-kB | GABA receptor
    In vitro:
    Molecules. 2015 Jan 14;20(1):1293-303.
    Ginsenoside Rc promotes anti-adipogenic activity on 3T3-L1 adipocytes by down-regulating C/EBPα and PPARγ.[Pubmed: 25594343]
    Panax ginseng and its major components, the ginsenosides, are widely used in oriental medicine for the prevention of various disorders.
    METHODS AND RESULTS:
    In the present study, the inhibitory activity of ginsenoside Rc on adipogenesis was investigated using the 3T3-L1 cell line. The results obtained showed that Rc reduced the proliferation and viability of 3T3-L1 preadipocytes in a dose-dependent manner. Treatment with Rc decreased the number of adipocytes and reduced lipid accumulation in maturing 3T3-L1 preadipocytes, demonstrating an inhibitory effect on lipogenesis. Moreover, it was found that Rc directly induced lipolysis in adipocytes and down-regulated the expression of major transcription factors of the adipogenesis pathway, such as PPARγ and C/EBPα.
    CONCLUSIONS:
    These findings indicate that Rc is capable of suppressing adipogenesis and therefore they seem to be natural bioactive factors effective in adipose tissue mass modulation.
    Arch Pharm Res. 2003 Jan;26(1):53-7.
    Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells.[Pubmed: 12568359]
    We have found that ginsenoside Rc and Re induce c-fos in MCF-7 human breast carcinoma cells at both the mRNA and protein levels. However, neither ginsenoside activated the expression of reporter gene under the control of AP-1/TPA response elements.
    METHODS AND RESULTS:
    We have also examined the possibility that ginsenoside Rc and Re act by binding to intracellular steroid hormone receptors that act as transcriptional factors in the nucleus in inducing c-fos mRNA in MCF7 human breast carcinoma cells. However, ginsenoside Rc and Re did not bind to glucocorticoid, androgen, estrogen, or retinoic acid receptors as examined by the transcription activation of the luciferase reporter genes in CV-1 cells that were transiently transfected with the corresponding steroid hormone receptors and hormone responsive luciferase reporter plasmids.
    CONCLUSIONS:
    These data demonstrate that ginsenoside Rc and Re act via other transcription factors and not via estrogen receptor in c-Fos expression.
    J Ginseng Res . 2017 Apr;41(2):127-133.
    Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2[Pubmed: 28413316]
    Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-α and interleukin-1β. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.
    In vivo:
    Am J Chin Med. 2016;44(3):595-615.
    Ginsenoside Rc from Korean Red Ginseng (Panax ginseng C.A. Meyer) Attenuates Inflammatory Symptoms of Gastritis, Hepatitis and Arthritis.[Pubmed: 27109153 ]
    Korean Red Ginseng (KRG) is an herbal medicine prescribed worldwide that is prepared from Panax ginseng C.A. Meyer (Araliaceae). Out of ginseng's various components, ginsenosides are regarded as the major ingredients, exhibiting anticancer and anti-inflammatory activities. Although recent studies have focused on understanding the anti-inflammatory activities of KRG, compounds that are major anti-inflammatory components, precisely how these can suppress various inflammatory processes has not been fully elucidated yet. In this study, we aimed to identify inhibitory saponins, to evaluate the in vivo efficacy of the saponins, and to understand the inhibitory mechanisms.
    METHODS AND RESULTS:
    To do this, we employed in vitro lipopolysaccharide-treated macrophages and in vivo inflammatory mouse conditions, such as collagen (type II)-induced arthritis (CIA), EtOH/HCl-induced gastritis, and lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-triggered hepatitis. Molecular mechanisms were also verified by real-time PCR, immunoblotting analysis, and reporter gene assays. Out of all the ginsenosides, ginsenoside Rc (G-Rc) showed the highest inhibitory activity against the expression of tumor necrosis factor (TNF)-[Formula: see text], interleukin (IL)-1[Formula: see text], and interferons (IFNs). Similarly, this compound attenuated inflammatory symptoms in CIA, EtOH/HCl-mediated gastritis, and LPS/D-galactosamine (D-GalN)-triggered hepatitis without altering toxicological parameters, and without inducing gastric irritation. These anti-inflammatory effects were accompanied by the suppression of TNF-[Formula: see text] and IL-6 production and the induction of anti-inflammatory cytokine IL-10 in mice with CIA. G-Rc also attenuated the increased levels of luciferase activity by IRF-3 and AP-1 but not NF-[Formula: see text]B. In support of this phenomenon, G-Rc reduced TBK1, IRF-3, and ATF2 phosphorylation in the joint and liver tissues of mice with hepatitis.
    CONCLUSIONS:
    Therefore, our results strongly suggest that G-Rc may be a major component of KRG with useful anti-inflammatory properties due to its suppression of IRF-3 and AP-1 pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9266 mL 4.6328 mL 9.2655 mL 18.531 mL 23.1638 mL
    5 mM 0.1853 mL 0.9266 mL 1.8531 mL 3.7062 mL 4.6328 mL
    10 mM 0.0927 mL 0.4633 mL 0.9266 mL 1.8531 mL 2.3164 mL
    50 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.3706 mL 0.4633 mL
    100 mM 0.0093 mL 0.0463 mL 0.0927 mL 0.1853 mL 0.2316 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Ra2; Ginsenoside Ra2 CFN93293 83459-42-1 C58H98O26 = 1211.39 5mg QQ客服:215959384
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:1457312923
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:2159513211
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:1413575084
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 1881225-08-6 C38H64O10 = 680.9 5mg QQ客服:215959384
    人参皂苷F3; Ginsenoside F3 CFN99978 62025-50-7 C41H70O13 = 770.99 20mg QQ客服:215959384
    人参皂苷F5; Ginsenoside F5 CFN95034 189513-26-6 C41H70O13 = 771.0 20mg QQ客服:2056216494
    人参皂苷Rg1; Ginsenoside Rg1 CFN99967 22427-39-0 C42H72O14 = 801.01 20mg QQ客服:215959384
    三七皂苷R1; Notoginsenoside R1 CFN99999 80418-24-2 C47H80O18 = 933.13 20mg QQ客服:1457312923
    人参皂苷Re; Ginsenoside Re CFN99974 52286-59-6 C48H82O18 = 947.15 20mg QQ客服:215959384

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