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  • 灵芝酸C1

    • 灵芝酸C1

    Ganoderic acid C1

    灵芝酸C1
    		产品编号 CFN92053
    CAS编号 95311-97-0
    分子式 = 分子量 C30H42O7 = 514.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸C1 CFN92053 95311-97-0 1mg QQ客服：1457312923
    灵芝酸C1 CFN92053 95311-97-0 5mg QQ客服：1457312923
    灵芝酸C1 CFN92053 95311-97-0 10mg QQ客服：1457312923
    灵芝酸C1 CFN92053 95311-97-0 20mg QQ客服：1457312923
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    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Helmholtz Zentrum München (Germany)
  • Sri Ramachandra University (India)
  • Srinakharinwirot University (Thailand)
  • Pennsylvania State University (USA)
  • University of Padjajaran (Indonesia)
  • FORTH-IMBB (Greece)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Queensland (Australia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University Medical Center Mainz (Germany)
  • University of Eastern Finland (Finland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2023, 13(1):7475.
  • Kasetsart University2022, ethesis.1144.
  • University of Burgos2024, ssrn.4795441.
  • Molecules.2019, 24(1):E159
  • VNU J Science: Med.&Pharm. Sci.2024.2588-1132
  • J Pharm Biomed Anal.2021, 196:113931.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Pharm Biol.2021, 59(1):134-145.
  • Antioxidants (Basel).2023, 12(12):2078.
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • J Ethnopharmacol.2016, 192:370-381
  • Research Square2021, 10.21203.
  • Food Chem Toxicol.2020, 135:110863
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Plant Physiol Biochem.2019, 144:355-364
  • Oxid Med Cell Longev2019, 9056845:13
  • Nutrients2022, 14(3),695.
  • Chemistry of Plant Materials.2019, 129-136
  • Foods2023, 12(23), 4342.
  • Int J Mol Sci.2022, 23(21):13406.
  • ...
    • 生物活性
    Description: Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
    Targets: NF-kB | MAPK | AP-1 | TNF-α | IFN-γ | IL Receptor | HIV
    In vitro:
    Inflamm Bowel Dis. 2015 May 19.
    Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling.[Pubmed: 25993687]

    METHODS AND RESULTS:
    Triterpene Ganoderic acid C1 (GAC1) was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to downregulation of the NF-κB signaling pathway.
    CONCLUSIONS:
    Ganoderic acid C1 inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation. Ganoderic acid C1 is a key beneficial constituent in G. lucidum and the Food Allergy Herbal Formula-2 in suppressing the inflammatory cytokines found in CD and warrants clinical investigation for the treatment of CD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9429 mL 9.7144 mL 19.4288 mL 38.8576 mL 48.572 mL
    5 mM 0.3886 mL 1.9429 mL 3.8858 mL 7.7715 mL 9.7144 mL
    10 mM 0.1943 mL 0.9714 mL 1.9429 mL 3.8858 mL 4.8572 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9714 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3886 mL 0.4857 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Hainanic acid B; Hainanic acid B CFN95526 1637737-46-2 C30H42O7 = 514.7 5mg QQ客服：1457312923
    新化合物18; New compound 18 CFN95527 N/A C30H44O7 = 516.7 5mg QQ客服：3257982914
    新化合物20; New compound 20 CFN95545 N/A C30H42O7 = 514.7 5mg QQ客服：2056216494
    丹芝酸A; Ganolucidic acid A CFN90299 98665-21-5 C30H44O6 = 500.67 5mg QQ客服：215959384
    丹芝酸B; Ganolucidic acid B CFN95513 98683-75-1 C30H46O6 = 502.7 5mg QQ客服：3257982914
    灵芝酸B; Ganoderic acid B CFN92052 81907-61-1 C30H44O7 = 516.7 20mg QQ客服：3257982914
    灵芝酸B甲酯; Methyl ganoderate B CFN95551 81907-65-5 C31H46O7 = 530.7 5mg QQ客服：1457312923
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 10mg QQ客服：1413575084
    灵芝烯酸B甲酯; Methyl ganoderenate B CFN95534 N/A C31H44O7 = 528.7 5mg QQ客服：3257982914
    3beta,7beta,12beta-三羟基-11,15,23-三羰基-羊毛甾-8,20-二烯-26-酸; (3beta,7beta,12beta,20Z)- 3,7,12- trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid CFN91782 1961358-02-0 C30H42O8 = 530.66 5mg QQ客服：1457312923

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