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  • 灵芝酸C1

    Ganoderic acid C1

    灵芝酸C1
    产品编号 CFN92053
    CAS编号 95311-97-0
    分子式 = 分子量 C30H42O7 = 514.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸C1 CFN92053 95311-97-0 1mg QQ客服:1457312923
    灵芝酸C1 CFN92053 95311-97-0 5mg QQ客服:1457312923
    灵芝酸C1 CFN92053 95311-97-0 10mg QQ客服:1457312923
    灵芝酸C1 CFN92053 95311-97-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
  • Regional Crop Research Institute (Korea)
  • Washington State University (USA)
  • St. Jude Children Research Hospital (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Nanjing University of Chinese Medicine (China)
  • Florida A&M University (USA)
  • Celltrion Chemical Research Institute (Korea)
  • Stanford University (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Rio de Janeiro State University (Brazil)
  • The Ohio State University (USA)
  • University of Fribourg (Switzerland)
  • Institute of Chinese Materia Medica (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol.2019, 71:22-31
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Molecules.2021, 26(9):2526.
  • J Food Compos Anal2017, 62:197-204
  • Sci Adv.2018, 4(10)
  • BMC Complement Altern Med.2017, 17(1):393
  • J Biol Chem.2014, 289(3):1723-31
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Phytomedicine.2017, 24:77-86
  • Br J Pharmacol.2018, 175(6):902-923
  • Int J Mol Sci.2019, 20(11):E2734
  • Life Sci.2022, 298:120488.
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Separations2023, 10(2), 131.
  • Int J Mol Sci.2023, 25(1):283.
  • J Appl Toxicol.2020, 40(7):965-978.
  • Sci Rep.2024, 14(1):3684.
  • RSC Advances2017, 86
  • ACS Omega.2023, 9(1):1278-1286.
  • J Food Sci.2024, 3841.17112.
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Toxicological Research2020, doi: 10.1007.
  • Toxicol In Vitro.2023, 93:105667.
  • ...
  • 生物活性
    Description: Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
    Targets: NF-kB | MAPK | AP-1 | TNF-α | IFN-γ | IL Receptor | HIV
    In vitro:
    Inflamm Bowel Dis. 2015 May 19.
    Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling.[Pubmed: 25993687]

    METHODS AND RESULTS:
    Triterpene Ganoderic acid C1 (GAC1) was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to downregulation of the NF-κB signaling pathway.
    CONCLUSIONS:
    Ganoderic acid C1 inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation. Ganoderic acid C1 is a key beneficial constituent in G. lucidum and the Food Allergy Herbal Formula-2 in suppressing the inflammatory cytokines found in CD and warrants clinical investigation for the treatment of CD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9429 mL 9.7144 mL 19.4288 mL 38.8576 mL 48.572 mL
    5 mM 0.3886 mL 1.9429 mL 3.8858 mL 7.7715 mL 9.7144 mL
    10 mM 0.1943 mL 0.9714 mL 1.9429 mL 3.8858 mL 4.8572 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9714 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3886 mL 0.4857 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新化合物20; New compound 20 CFN95545 N/A C30H42O7 = 514.7 5mg QQ客服:215959384
    丹芝酸A; Ganolucidic acid A CFN90299 98665-21-5 C30H44O6 = 500.67 5mg QQ客服:1413575084
    丹芝酸B; Ganolucidic acid B CFN95513 98683-75-1 C30H46O6 = 502.7 5mg QQ客服:2159513211
    灵芝酸B; Ganoderic acid B CFN92052 81907-61-1 C30H44O7 = 516.7 20mg QQ客服:1413575084
    灵芝酸B甲酯; Methyl ganoderate B CFN95551 81907-65-5 C31H46O7 = 530.7 5mg QQ客服:2159513211
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 10mg QQ客服:2159513211
    灵芝烯酸B甲酯; Methyl ganoderenate B CFN95534 N/A C31H44O7 = 528.7 5mg QQ客服:2056216494
    3beta,7beta,12beta-三羟基-11,15,23-三羰基-羊毛甾-8,20-二烯-26-酸; (3beta,7beta,12beta,20Z)- 3,7,12- trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid CFN91782 1961358-02-0 C30H42O8 = 530.66 5mg QQ客服:1413575084
    灵芝酸C2; Ganoderic acid C2 CFN92054 103773-62-2 C30H46O7 = 518.7 20mg QQ客服:1413575084
    灵芝酸A; Ganoderic acid A CFN92051 81907-62-2 C30H44O7 = 516.7 20mg QQ客服:3257982914

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