Info: Read More
  • 中药标准品生产商,产品定制服务
  • 灵芝烯酸B

    Ganoderenic acid B

    灵芝烯酸B
    产品编号 CFN92991
    CAS编号 100665-41-6
    分子式 = 分子量 C30H42O7 = 514.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝烯酸B CFN92991 100665-41-6 1mg QQ客服:215959384
    灵芝烯酸B CFN92991 100665-41-6 5mg QQ客服:215959384
    灵芝烯酸B CFN92991 100665-41-6 10mg QQ客服:215959384
    灵芝烯酸B CFN92991 100665-41-6 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Griffith University (Australia)
  • Almansora University (Egypt)
  • Utah State University (USA)
  • Macau University of Science and Technology (China)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Korea Food Research Institute(KFRI) (Korea)
  • Universit?t Basel (Switzerland)
  • MTT Agrifood Research Finland (Finland)
  • Universidad Industrial de Santander (Colombia)
  • University of Hertfordshire (United Kingdom)
  • University of Limpopo (South Africa)
  • National Chung Hsing University (Taiwan)
  • Harvard University (USA)
  • Lodz University of Technology (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Quality and Safety2018, 2:213-219
  • Journal of Molecular Liquids2021, 334:116014.
  • Horticulture Research2020, 7:111.
  • Molecules.2019, 24(10):E1930
  • Appl. Sci.2022, 12(4), 2032.
  • Molecules.2019, 24(6):E1177
  • Molecules.2021, 26(9):2765.
  • Phytochem Anal.2023, pca.3305.
  • Molecules.2019, 24(16):E3003
  • Food Chemistry2023, 137837.
  • Nutr Res Pract.2020, 14(3):203-217.
  • Molecules.2020, 25(20):4851.
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Neurotoxicology.2022, 91:218-227.
  • J Food Biochem.2019, 43(9):e12970
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Molecules2022, 27(9):2827.
  • Pharmaceutics.2022, 14(3):564.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Chin Med.2022, 17(1):66.
  • Molecules.2023, 28(3):958.
  • ...
  • 生物活性
    Description: Ganoderenic acid B can enhance the cytotoxicity of chemotherapeutics towards ABCB1-mediated MDR cancer cells via inhibition of the transport function of ABCB1.
    In vitro:
    Int J Oncol. 2015 May;46(5):2029-38.
    Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells.[Pubmed: 25779097 ]
    Chemotherapy is one of the most common therapeutic option for metastatic tumors and hematological malignancies. ABCB1-mediated multidrug resistance is the major obstacle for chemotherapy. Natural products with diversified structures are ideal source of ABCB1 modulators.
    METHODS AND RESULTS:
    Ganoderenic acid B, a lanostane-type triterpene isolated from Ganoderma lucidum, exhibited potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to doxorubicin, vincristine and paclitaxel. Similarly, Ganoderenic acid B could also significantly reverse the resistance of ABCB1-overexpressing MCF-7/ADR cells to doxorubicin. Furthermore, Ganoderenic acid B notably enhanced intracellular accumulation of rhodamine-123 in HepG2/ADM cells through inhibition of its efflux. ABCB1 siRNA interference assay indicated that the reversal activity of Ganoderenic acid B was dependent on ABCB1. Further mechanistic investigations found that Ganoderenic acid B did not alter the expression level of ABCB1 and the activity of ABCB1 ATPase. Molecular docking model displayed that the positions of Ganoderenic acid B binding to ABCB1 were different from the region of verapamil interacted with ABCB1.
    CONCLUSIONS:
    Collectively, Ganoderenic acid B can enhance the cytotoxicity of chemotherapeutics towards ABCB1-mediated MDR cancer cells via inhibition of the transport function of ABCB1. These findings provide evidence that Ganoderenic acid B has the potential to be developed into an ABCB1-mediated multidrug resistance reversal agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9431 mL 9.7153 mL 19.4307 mL 38.8614 mL 48.5767 mL
    5 mM 0.3886 mL 1.9431 mL 3.8861 mL 7.7723 mL 9.7153 mL
    10 mM 0.1943 mL 0.9715 mL 1.9431 mL 3.8861 mL 4.8577 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9715 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3886 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸C1; Ganoderic acid C1 CFN92053 95311-97-0 C30H42O7 = 514.7 5mg QQ客服:2159513211
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 10mg QQ客服:3257982914
    灵芝烯酸G; Ganoderenic acid G CFN95517 120481-73-4 C30H40O7 = 512.6 5mg QQ客服:1457312923
    灵芝酸 J; Ganoderic acid J CFN95516 100440-26-4 C30H42O7 = 514.7 10mg QQ客服:3257982914
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 20mg QQ客服:215959384
    灵芝酸D甲酯; Methyl ganoderate D CFN95581 97210-12-3 C31H44O7 = 528.7 5mg QQ客服:3257982914
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 5mg QQ客服:2056216494
    12-乙酰氧基灵芝酸D; 12-Acetoxy ganoderic acid D CFN95535 N/A C32H44O9 = 572.7 5mg QQ客服:1457312923
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 10mg QQ客服:2159513211
    灵芝酸Z; Ganoderic acid Z CFN90295 294674-09-2 C30H42O7 = 514.66 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产