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  • 1-羟基-9H-咔唑-3-甲醛

    Demethylmurrayanine

    1-羟基-9H-咔唑-3-甲醛
    产品编号 CFN97840
    CAS编号 123497-84-7
    分子式 = 分子量 C13H9NO2 = 211.22
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Clausena dunniana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-羟基-9H-咔唑-3-甲醛 CFN97840 123497-84-7 1mg QQ客服:1413575084
    1-羟基-9H-咔唑-3-甲醛 CFN97840 123497-84-7 5mg QQ客服:1413575084
    1-羟基-9H-咔唑-3-甲醛 CFN97840 123497-84-7 10mg QQ客服:1413575084
    1-羟基-9H-咔唑-3-甲醛 CFN97840 123497-84-7 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • ...
  • 生物活性
    Description: O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml.
    In vitro:
    Phytochem. Lett.,2014, 9(3):92-95.
    Two new cytotoxic constituents from the Clausena lansium (Lour.) Skeels[Reference: WebLink]

    METHODS AND RESULTS:
    Two new compounds 6-methoxy-9H-carbazole-3-carboxylic acid ( 1 ) and 9-[3-methyl-4-(4-methyl-5-oxo-tetrapydro-furan-2-yl)-but-2-enyloxy]-furo[3,2-g]chromen-7-one ( 5 ) along with four known compounds clausine D ( 2 ), claulansines J ( 3 ), O-Demethylmurrayanine ( 4 ) and pabularinone ( 6 ) were isolated from the Clausena lansium . The chemical structures of the new compound were elucidated by 1D and 2D NMR as well as HR-ESIMS spectral analysis. All the compounds isolated were evaluated for cytotoxic effects against human breast cancer (MCF-7), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721).
    CONCLUSIONS:
    Compounds 2 and 4 exhibited strong cytotoxicity against MCF-7 and SMMC-7721 with IC 50 values in the range 2.63–7.5902μg/ml, and Compounds 1 and 5 showed moderate cytotoxicity against MCF-7, H1299 and SMMC-7721 tumor cell lines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.7344 mL 23.672 mL 47.344 mL 94.688 mL 118.36 mL
    5 mM 0.9469 mL 4.7344 mL 9.4688 mL 18.9376 mL 23.672 mL
    10 mM 0.4734 mL 2.3672 mL 4.7344 mL 9.4688 mL 11.836 mL
    50 mM 0.0947 mL 0.4734 mL 0.9469 mL 1.8938 mL 2.3672 mL
    100 mM 0.0473 mL 0.2367 mL 0.4734 mL 0.9469 mL 1.1836 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Clausine E; Clausine E CFN91823 182261-83-2 C14H11NO3 = 241.2 5mg QQ客服:1413575084
    1,6-二羟基-9H-咔唑-3-甲醛; Clausine Z CFN97428 866111-14-0 C13H9NO3 = 227.2 5mg QQ客服:2056216494
    1-羟基-6-甲氧基-9H-咔唑-3-甲醛; Clausine I CFN97800 182261-94-5 C14H11NO3 = 241.24 5mg QQ客服:215959384
    2,8-二羟基-9H-咔唑-3-甲醛; Clauszoline M CFN97796 187110-72-1 C13H9NO3 = 227.22 5mg QQ客服:3257982914
    柯里九里香碱; Curryangine CFN92926 25488-37-3 C23H25NO = 331.45 5mg QQ客服:215959384
    Murrayamine E; Murrayamine E CFN92927 172617-68-4 C23H25NO2 = 347.45 5mg QQ客服:1457312923
    柯九里香甲碱; Koenigicine CFN70319 24123-92-0 C20H21NO3 = 323.4 5mg QQ客服:3257982914
    马汉九里香碱; Mahanimbine CFN92197 21104-28-9 C23H25NO = 331.5 5mg QQ客服:1457312923
    异马汉九里香碱; Isomahanimbine CFN92198 26871-46-5 C23H25NO = 331.5 5mg QQ客服:1457312923
    Mahanine; Mahanine CFN92199 28360-49-8 C23H25NO2 = 347.5 5mg QQ客服:2056216494

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