莪术双环烯酮

Curcumenone

	产品编号	CFN92026
	CAS编号	100347-96-4
	分子式 = 分子量	C₁₅H₂₂O₂ = 234.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The rhizomes of Curcuma zedoaria
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
莪术双环烯酮	CFN92026	100347-96-4	1mg	QQ客服：1413575084
莪术双环烯酮	CFN92026	100347-96-4	5mg	QQ客服：1413575084
莪术双环烯酮	CFN92026	100347-96-4	10mg	QQ客服：1413575084
莪术双环烯酮	CFN92026	100347-96-4	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Pennsylvania State University (USA)

University of Zurich (Switzerland)

Instituto Politécnico de Bragan?a (Portugal)

Johannes Gutenberg University Mainz (JGU) (Germany)

Sant Gadge Baba Amravati University (India)

Center for protein Engineering (CIP) (Belgium)

University of Queensland (Australia)

Universidad Miguel Hernández (Spain)

University of Vigo (Spain)

Kamphaengphet Rajabhat University (Thailand)

University of British Columbia (Canada)

Medizinische Universit?t Wien (Austria)

Wageningen University (Netherlands)

University of Otago (New Zealand)

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Description:

Curcumenone may have protective effect on drunkenness, through increasing liver alcohol dehydrogenase activity.

In vitro:

Int J Mol Sci. 2015 Mar 6;16(3):5180-93.

Spectrofluorometric and molecular docking studies on the binding of curcumenol and curcumenone to human serum albumin.[Pubmed: 25756376]

Curcumenol and Curcumenone are two major constituents of the plants of medicinally important genus of Curcuma, and often govern the pharmacological effect of these plant extracts.
METHODS AND RESULTS:
These two compounds, isolated from C. zedoaria rhizomes were studied for their binding to human serum albumin (HSA) using the fluorescence quench titration method. Molecular docking was also performed to get a more detailed insight into their interaction with HSA at the binding site. Additions of these sesquiterpenes to HSA produced significant fluorescence quenching and blue shifts in the emission spectra of HSA. Analysis of the fluorescence data pointed toward moderate binding affinity between the ligands and HSA, with Curcumenone showing a relatively higher binding constant (2.46 × 105 M-1) in comparison to curcumenol (1.97 × 104 M-1).
CONCLUSIONS:
Cluster analyses revealed that site I is the preferred binding site for both molecules with a minimum binding energy of -6.77 kcal·mol-1. However, binding of these two molecules to site II cannot be ruled out as the binding energies were found to be -5.72 and -5.74 kcal·mol-1 for curcumenol and Curcumenone, respectively. The interactions of both ligands with HSA involved hydrophobic interactions as well as hydrogen bonding.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide; 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide	CFN99095	1093207-99-8	C₁₃H₂₀O₃ = 224.3	5mg	QQ客服：215959384
叶黄制菌素; Xanthatin	CFN98315	26791-73-1	C₁₅H₁₈O₃ = 246.3	5mg	QQ客服：2056216494
8-Epixanthatin; 8-Epixanthatin	CFN89507	30890-35-8	C₁₅H₁₈O₃ = 246.30	5mg	QQ客服：215959384
6alpha-Hydroxytomentosin; 6alpha-Hydroxytomentosin	CFN89001	1232676-22-0	C₁₅H₂₀O₄ = 264.32	5mg	QQ客服：2159513211
黄质宁; Xanthinin	CFN99644	153483-31-9	C₁₇H₂₂O₅ = 306.4	5mg	QQ客服：1413575084
旋覆花内酯; Britannilactone	CFN92601	33620-72-3	C₁₅H₂₂O₄ = 266.3	20mg	QQ客服：2159513211
1-O-乙酰旋覆花内酯; 1-O-Acetyl britannilactone	CFN90219	681457-46-5	C₁₇H₂₄O₅ = 266.34	20mg	QQ客服：2159513211
1,6-O,O-二乙酰大花旋覆花内酯; 1,6-O,O-Diacetylbritannilactone	CFN89518	1286694-67-4	C₁₉H₂₆O₆ = 350.40	5mg	QQ客服：2056216494
1-O-乙酰-6β-O-异丁酰旋覆花内酯; 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone	CFN92598	1087072-50-1	C₂₁H₃₀O₆ = 378.5	5mg	QQ客服：2159513211
1-O-乙酰基-6alpha-O-(2-甲基丁酰)大花旋覆花内酯; 1-O-Acetyl-6alpha-O-(2-methylbutyryl)britannilactone	CFN89470	1932687-71-2	C₂₂H₃₂O₆ = 392.48	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.268 mL	21.3402 mL	42.6803 mL	85.3606 mL	106.7008 mL
5 mM	0.8536 mL	4.268 mL	8.5361 mL	17.0721 mL	21.3402 mL
10 mM	0.4268 mL	2.134 mL	4.268 mL	8.5361 mL	10.6701 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	1.7072 mL	2.134 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	0.8536 mL	1.067 mL